Brucella at the dawn of the third millenium: Genomic organization and pathogenesis;Brucella à l'aube du troisième brucella à l'aube du troisième millénaire:millénaire: Organisation du génome et pouvoir organisation du génome et pouvoir pathogène

Pathologie Biologie

Volumn 50, Issue 6, 2002, Pages 401-412

  Michaux Charachon, Sylvie ^a   Foulongne, Vincent ^a   O'Callaghan, David ^a   Ramuz, Michel ^a  

^a INSERM   (France)

Author keywords

Brucella; Complex genome; Pathogenesis; Virulence factors; proteobacteria

Indexed keywords

ANTIBIOTIC AGENT; BRUCELLA VACCINE; VIRULENCE FACTOR;

BACTERIAL CHROMOSOME; BACTERIAL GENOME; BACTERIAL VIRULENCE; BRUCELLA; BRUCELLOSIS; GRAM NEGATIVE BACTERIUM; NONHUMAN; PATHOGENESIS; REVIEW; ZOONOSIS;

BRUCELLA;

EID: 17644433556     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0369-8114(02)00313-9     Document Type: Review

References (61)

1. An overview of human brucellosis
2. Brucellosis: A worldwide zoonosis
3. Genus Brucella Meyer and Shaw 1920
4. Brucella, a monospecific genus as shown by deoxyribonucleic acid hybridization
5. Genome structure and phylogeny in the genus Brucella
6. Brucella abortus 16S rRNA and lipid A reveal a phylogenetic relationship with members of the alpha-2 subdivision of the class Proteobacteria
7. DNA polymorphism in stains of the genus Brucella
8. Polymorphism in Brucella strains detected by studying distribution of two short repetitive DNA elements
9. DNA polymorphism at the omp-31 locus of Brucella spp.: Evidence for a large deletion in Brucella abortus, and other species-specific markers
10. Molecular characterization of a Brucella species large DNA fragment deleted in Brucella abortus strains: Evidence for a locus involved in the synthesis of a polysaccharide
11. The characterisation of Brucella strains isolated from marine mammals
12. Human exposure to Brucella recovered from a sea mammal
13. Molecular characterization of Brucella strains isolated from marine mammals
14. Genomic fingerprinting and develpment of a dendrogram for Brucella spp. isolated from seals, porpoises, and dolphins
15. Presence of two indépendant chromosomes in the Brucella melitensis genome
16. Differences in chromosome number and genome rearrangements in the genus Brucella
17. Rearrangements in the genome of the bacterium Salmonella typhi
18. Unconventional genomic organization in the alpha subgroup of the Proteobacteria
19. Genome evolution within the alpha Proteobacteria: Why do some bacteria not possess plasmids and others exhibit more than one different chromosome?
20. Pathogenesis of abortion of bovine brucellosis
21. Interactions between professionnal phagocytes and Brucella spp
22. Molecular basis of Brucella pathogenicity: An update
23. Early events and implication of F-actin and annexin I associated structures in the phagocytic uptake of Brucella suis by the J-774A. 1 murine cell line and human monocytes
24. Intracellular trafficking of Brucella abortus in J774 macrophages
25. Virulent Brucella abortus prevents lysosome fusion and is distributed within autophagosome-like compartments
26. Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of non professionnel phagocytes
27. Intracellular survival of Brucella spp. in human monocytes involves conventionnal uptake but special phagosomes
28. Brucella suis-impaired specific recognition of phagosomes by lysosomes due to phagosomal membrane modifications
29. Early acidification of phagosomes containing Brucella suis is essential for intracellular survival in murine macrophages
30. The Brucella suis virB operon is induced intracellularly in macrophages
31. In vitro Brucella suis infection prevents the programmed cell death of human monocytic cells
32. Brucella species release a specific, protease-sensitive, inhibitor of TNF-alpha expression, active on human macrophage-like cells
33. Majo outer membrane protein Omp25 of Brucella suis is involved in inhibition of tumor necrosis factor alpha production during infection of human macrophages
34. A two-component regulatory system playing a critical rôle in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence
35. A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis
36. Systèmes de sécrétion des protéines de type IV et virulence bactérienne
37. Identification of genes required for chronic persistence of Brucella abortus in mice
38. A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication
39. Essential rôle of the VirB machinery in the maturation of the Brucella abortus-containing vacuole
40. Identification of Brucella spp. genes involved in intracellular trafficking
41. Identification and characterization of in vivo attenuated mutants of Brucella melitensis
42. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis
43. Signature-tagged mutagenesis in the identification of virulence genes in pathogens
44. Functional analysis of the ClpATPase ClpA of Brucella suis, and persistence of a knockout mutant in BALB/c mice
45. Characterization of Brucella suis clpB and clpAB mutants and participation of the genes in stress responses
46. Brucella abortus HtrA functions as an authentic stress response protease but is not requires for wild-type virulencein BALB/c mice
47. Participation of the molecular chaperone DnaK in intracellular growth of Brucella suis within U937-derived phagocytes
48. Strategies for isolation of in vivo expressed genes from bacteria
49. Constitutive and inducible expression of green fluorescent protein in Brucella suis
50. Protein synthesis in Brucella abortus induced during macrophage infection
51. Identification and comparison of macrophage-induced proteins and proteins induced under various stress conditions in Brucella abortus
52. Identification and characterization of Brucella ovis immunogenic proteins using two-dimensional electrophoresis and immunoblotting
53. Mapping and identification of Brucella melitensis proteins by two-dimensional elctrophoresis and microsequencing
54. Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry
55. On the presence and organization of open reading frames of the nonmotile pathogen Brucella abortus similar to class II, III and IV flagellar genes and to LcrD virulence superfamily
56. Intracellular lifestyle of Brucella spp. Common genes with other animal pathogens, plant pathogens, and endosymbionts
57. Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival
58. Molecular cloning and characterization of cgs, the Brucella abortus cyclic β(1-2) glucan synthetase gene: Genetic complementation of Rhizobium meliloti ndvB and Agrobacterium tumefaciens chvB mutants
59. Brucella abortus cyclic β(1-2) glucan mutants have reduced virulence in mice and are defective in intracellular replication in HeLa cells
60. Gene discovery through genomic sequencing of Brucella abortus
61. Is Brucella abortus a facultative intracellular pathogen with mitochondria-like activity?