Enzyme-linked immunospot assay responses to early secretory antigenic target 6, culture filtrate protein 10, and purified protein derivative among children with tuberculosis: Implications for diagnosis and monitoring of therapy

Clinical Infectious Diseases

Volumn 40, Issue 9, 2005, Pages 1301-1308

  Nicol, M P ^a   Pienaar, D ^a   Wood, K ^a   Eley, B ^a   Wilkinson, R J ^a,b   Henderson, H ^a   Smith, L ^a   Samodien, S ^a   Beatty, D ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CULTURE FILTRATE PROTEIN 10; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; TUBERCULIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; CHILD; CONTROLLED STUDY; DIAGNOSTIC TEST; ENZYME LINKED IMMUNOSPOT ASSAY; HUMAN; INFANT; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; PATIENT MONITORING; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

ANTIGENS, BACTERIAL; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; SENSITIVITY AND SPECIFICITY; TUBERCULIN; TUBERCULOSIS;

EID: 17644386594     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/429245     Document Type: Article

References (17)

1. Zar HJ. Tuberculosis in the developing world. Pediatr Pulmonol Suppl 2004; 26:53-4.
2. Hesseling AC, Schaaf HS, Gie RP, Starke JR, Beyers N. A critical review of diagnostic approaches used in the diagnosis of childhood tuberculosis. Int J Tuberc Lung Dis 2002; 6:1038-45.
3. Berthet FX, Rasmussen PB, Rosenkrands I, Andersen P, Gicquel B. A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10). Microbiology 1998; 144:3195-203.
4. Arend SM, Andersen P, van Meijgaarden KE, et al. Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10. J Infect Dis 2000; 181:1850-4.
5. Arend SM, Engelhard AC, Groot G, et al. Tuberculin skin testing compared with T-cell responses to Mycobacterium tuberculosis-specific and nonspecific antigens for detection of latent infection in persons with recent tuberculosis contact. Clin Diagn Lab Immunol 2001; 8:1089-96.
6. Black GF, Weir RE, Chaguluka SD, et al. Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-Mycobacterium bovis BCG-vaccinated Malawian young adults. Clin Diagn Lab Immunol 2003; 10:602-11.
7. Chapman AL, Munkanta M, Wilkinson KA, et al. Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells. AIDS 2002; 16:2285-93.
8. Ewer K, Deeks J, Alvarez L, et al. Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak. Lancet 2003; 361:1168-73.
9. Lalvani A, Pathan AA, Durkan H, et al. Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells. Lancet 2001; 357:2017-21.
10. Hill PC, Brookes RH, Fox A, et al. Large-scale evaluation of enzyme-linked immunospot assay and skin test for diagnosis of Mycobacterium tuberculosis infection against a gradient of exposure in The Gambia. Clin Infect Dis 2004; 38:966-73.
11. Lalvani A, Pathan AA, McShane H, et al. Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells. Am J Respir Crit Care Med 2001;163:824-8.
12. Verver S, Warren RM, Munch Z, et al. Transmission of tuberculosis in a high incidence urban community in South Africa. Int J Epidemiol 2004; 33:351-7.
13. Lalvani A, Nagvenkar P, Udwadia Z, et al. Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians. J Infect Dis 2001; 183:469-77.
14. Carrara S, Vincenti D, Petrosillo N, Amicosante M, Girardi E, Goletti D. Use of a T cell-based assay for monitoring efficacy of antituberculosis therapy. Clin Infect Dis 2004; 38:754-6.
15. Mawa PA, Pickering JM, Miiro G, et al. The effect of tuberculin skin testing on viral load and anti-mycobacterial immune responses in HIV-1-infected Ugandan adults. Int J Tuberc Lung Dis 2004;8:586-92.
16. Wilkinson KA, Wilkinson RJ, Pathan A, et al. Ex vivo characterization of early secretory antigenic target 6 (ESAT-6) specific T cells at sites of active disease in pleural tuberculosis. Clin Infect Dis 2005; 40:184-7.
17. Hussain R, Kaleem A, Shahid F, et al. Cytokine profiles using whole-blood assays can discriminate between tuberculosis patients and healthy endemic controls in a BCG-vaccinated population. J Immunol Methods 2002; 264:95-108.