Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m)

European Journal of Clinical Pharmacology

Volumn 61, Issue 1, 2005, Pages 39-46

  Streit, Michael ^a   Göggelmann, Christoph ^a   Dehnert, Christoph ^a   Burhenne, Jürgen ^a   Riedel, Klaus Dieter ^a   Menold, Elmar ^a   Mikus, Gerd ^a   Bärtsch, Peter ^a   Haefeli, Walter E ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cytochrome; Hepatic blood flow; High altitude; Hypoxia; Pharmacokinetic; Theophylline; Verapamil

Indexed keywords

1,3 DIMETHYLURIC ACID; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; NORVERAPAMIL; PARACETAMOL; THEOPHYLLINE; VERAPAMIL; CALCIUM CHANNEL BLOCKING AGENT; CYP3A PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; VASODILATOR AGENT;

ADULT; ALTITUDE; APPETITE DISORDER; ARTICLE; BLOOD OXYGEN TENSION; COLLAPSE; CONCENTRATION LOSS; CONTROLLED STUDY; DIZZINESS; DOPPLER ECHOGRAPHY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG HALF LIFE; HEADACHE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETER; NAUSEA; NORMAL HUMAN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; RANDOMIZATION; VOMITING; ANOXIA; AREA UNDER THE CURVE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; ENZYMOLOGY; HALF LIFE TIME; INTRAVENOUS DRUG ADMINISTRATION; LIVER CIRCULATION; METABOLISM; RANDOMIZED CONTROLLED TRIAL;

ADULT; ALTITUDE; ANOXIA; AREA UNDER CURVE; CALCIUM CHANNEL BLOCKERS; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; HALF-LIFE; HUMANS; INFUSIONS, INTRAVENOUS; LIVER CIRCULATION; MALE; THEOPHYLLINE; VASODILATOR AGENTS; VERAPAMIL;

EID: 17644375507     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-004-0886-1     Document Type: Article

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