Urinary excretion of meperidine and normeperidine in man upon acute and chronic exposure to high altitude

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 18, Issue 1, 1996, Pages 49-53

  Ritschel, W A ^a,d   Paulos, C ^b   Arancibia, A ^b   Pezzani, M ^b   Agrawal, M ^a   Wetzelsberger, K ^c   Lucker P W ^c  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

^c Institute of Clinical Pharmacology   (Germany)

^d UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

high altitude; meperidine; normeperidine; urinary excretion

Indexed keywords

DRUG METABOLITE; NORPETHIDINE; PETHIDINE;

ADULT; ALTITUDE; ARTICLE; CONTROLLED STUDY; DRUG EXCRETION; DRUG METABOLISM; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; URINARY EXCRETION; URINE PH; VOLUNTEER;

ADOLESCENT; ADULT; ALTITUDE; ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; CHOLINESTERASE INHIBITORS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MEPERIDINE;

EID: 0029878039     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Honigman, B., Theis, M.K., Koziol-McLain, J. et al. Acute mountain sickness in a general tourist population at moderate altitudes. Ann Int Med 1993, 118: 587-92.
2. Ritschel, W.A., Shapiro-Jacobson, M., Akileswaran, R., Wetzelsberger, K., Lücker, P.W. Meperidine uptake and binding to human blood ex vivo. Meth Find Exp Clin Pharmacol 1995, 17 (7): 477-81.
3. Ritschel, W.A., Paulos, C., Arancibia, A, et al. Pharmacokinetics of meperidine in man upon acute and chronic exposure to high altitude. J Clin Pharmacol. accepted for publication.
4. Ritschel, W.A. Cumulative urinary excretion. In: Handbook of Basic Pharmacokinetics, 4th Ed. Drug Intelligence Publications: Hamilton, IL 1992, 274-90.
5. Edwards, D.J., Svensson, C.K., Visco, J.P , Lalka, D. Clinical pharmacokinetics of pethidine: 1982. Clin Pharmacokinet 1982, 7: 421-33.
6. Dahlstrom, B.E., Paalzow, L.K., Lindberg, C., Bogentoft, C. Pharmacokinetics and analgesic effect of pethidine (meperidine) and its metabolites in the rat. Drug Metab Dispos 1979, 7: 108-12.
7. Yeh, S.Y., Krebs, H.A. TLC identification and GLC determination of meperidine and its metabolites in biological fluids. J Pharm Sci 1981, 70: 482-6.