Effect of metoprolol and verapamil administered separately and concurrently after single doses on liver blood flow and drug disposition

Journal of Clinical Pharmacology

Volumn 40, Issue 5, 2000, Pages 533-543

  Bauer, L A ^a   Horn, J R ^a   Maxon, M S ^a   Easterling, T R ^a   Shen, D D ^a   Strandness D E , Jr ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; METOPROLOL; VERAPAMIL;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG DISPOSITION; DRUG EFFECT; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODYNAMIC MONITORING; HUMAN; HYPERTENSION; LIVER BLOOD FLOW; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL;

EID: 0033663496     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912700022009152     Document Type: Article

References (25)

1. Changes in antipyrine and indocyanine green kinetics during nifedipine, verapamil, and diltiazem therapy
2. Influence of nifedipine therapy on indocyanine green and oral propranolol pharmacokinetics
3. The effects of oral nifedipine on hepatic blood flow in humans
4. Single and multiple doses of oral cimetidine do not change liver blood flow in humans
5. Liver blood flow, antipyrine clearance, and antipyrine metabolite formation clearance in patients with chronic active hepatitis and alcoholic cirrhosis
6. Estimation of hepatic blood flow in branches of hepatic vessels utilizing a noninvasive, duplex Doppler method
7. Disposition of drugs in cystic fibrosis: II. Hepatic blood flow
8. Acute effects of sublingual nitroglycerin on hepatic blood flow in healthy volunteers
9. Accuracy of duplex scanning for measurement of arterial volume flow
10. Measurement of cardiac output in pregnancy by Dop-Benedetti TJ pier technique
11. Measurement of cardiac output during pregnancy: Validation of Doppler technique and clinical observations in preeclampsia
12. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations
13. PCNONLIN and NONLIN84: Software for the statistical analysis of nonlinear models
14. Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data
15. Effects of d,lverapamil on atrioventricular conduction in relation to its stereoselective first-pass metabolism
16. The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans
17. Stereoselective first-pass metabolism of highly cleared drugs: Studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique
18. Identification of P450 enzymes involved in metabolism of verapamil in humans
19. Direct determination of hepatic extraction of verapamil in cardiac patients
20. Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers
21. Defective metabolism of metoprolol in poor hydroxylators of debrisoquine
22. Debrisoquine phenotype and the pharmacokinetics and beta-2 receptor pharmacodynamics of metoprolol and its enantiomers
23. Pharmacokinetics of metoprolol in patients with hepatic Cirrhosis
24. Hepatic clearance of drugs: I. Theoretical considerations of a 'well-stirred' model and a 'parallel tube' model: Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance
25. Commentary: A physiological approach to hepatic drug clearance