Combined radiotherapy and chemotherapy (cisplatin and 5-fluorouracil) as palliative treatment for localized unresectable or adjuvant treatment for resected pancreatic adenocarcinoma: Results of a feasibility study

International Journal of Radiation Oncology Biology Physics

Volumn 46, Issue 4, 2000, Pages 903-911

  André, Thierry ^a   Balosso, Jacques ^a   Louvet, Christophe ^b   Hannoun, Laurent ^c   Houry, Sidney ^a   Huguier, Michel ^a   Colonna, Marc ^b   Lotz, Jean Pierre ^a   De Gramont, Aimery ^b   Bellaïche, Annie ^a   Parc, Roland ^c   Touboul, Emmanuel ^a   Izrael, Victor ^a  

^a HÔPITAL TENON   (France)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

^c HÔPITAL SAINT ANTOINE   (France)

Author keywords

Chemotherapy; Combined treatment; Pancreatic carcinoma; Radiotherapy

Indexed keywords

CISPLATIN;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GASTROINTESTINAL TOXICITY; HUMAN; MULTIMODALITY CANCER THERAPY; NEUTROPENIA; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; SURVIVAL RATE; WEIGHT REDUCTION;

ADENOCARCINOMA; ADULT; AGED; ANALYSIS OF VARIANCE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CISPLATIN; COMBINED MODALITY THERAPY; FEASIBILITY STUDIES; FEMALE; FLUOROURACIL; HUMANS; MALE; MATCHED-PAIR ANALYSIS; MIDDLE AGED; NEOPLASM STAGING; PALLIATIVE CARE; PANCREATIC NEOPLASMS; QUALITY OF LIFE; SURVIVAL ANALYSIS;

EID: 17544392986     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(99)00478-2     Document Type: Article

References (35)

1. Gudjonsson B. Cancer of the pancreas. 50 years of surgery. Cancer. 60:1987;2284-2303.
2. Furhrman G.M., Charnsangavej C., Abbruzzese J.L., et al. Thin-section, contrast-enhanced computed tomography accurately predicts the resectability of malignant pancreatic neoplasm. Am J Surg. 167:1994;104-113.
3. Turk P., Wanebo H.J., Glicksman A., et al. Multimodality protocol for locally advanced carcinoma of the pancreas a pilot program . (Abstr.) Proc Am Soc Clin Oncol. 11:1992;564.
4. Kamthan A.G., Morris J.C., Dalton J., et al. Combined modality therapy for stage II and stage III pancreatic carcinoma. J Clin Oncol. 15:1997;2920-2927.
5. Jessup J.M., Steele G., Mayer R.J., et al. Neoadjuvant therapy for unresectable pancreatic adenocarcinoma. Arch Surg. 128:1993;559-564.
6. Tsuchiya R., Noda T., Harada N., et al. Collective review of small carcinomas of the pancreas. Ann Surg. 203:1986;77-81.
7. Trede M., Schwall G., Saeger H.D. Survival after pancreaticoduodenectomy. Ann Surg. 211:1990;447-458.
8. Baumel H., Huguier M., Manderscheid J.C., et al. Results of resection for cancer of the exocrine pancreas a study from the French Association of Surgery . Br J Surg. 81:1994;102-107.
9. Kayahara M., Nagakawa T., Ueno K., et al. An evaluation of radical resection for pancreatic cancer based on the mode of recurrence as determined by autopsy and diagnostic imaging. Cancer. 72:1993;2118-2123.
10. Foo M.L., Gunderson L.L., Nagorney D.M., et al. Patterns of failure in grossly resected pancreatic ductal adenocarcinoma treated with adjuvant irradiation ±5-fluorouracil. Int J Radiat Oncol Biol Phys. 26:1993;483-489.
11. Abbruzzese JL. Pancreatic cancer: overview of current and future therapeutic approaches. In: Educational Book of the American Association of Clinical Oncology, Annual meeting, 17-20 May 1997, Denver. Columbia, MO: Michael MC Perry;1997. pp. 65-70.
12. Kalser M.H., Ellenberg S.S. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg. 120:1985;899-903.
13. Klinkenbijl J.H.G., Sahmoud T., van Pel R., et al. Radiotherapy and 5FU after curative resection for cancer of the pancreas and peri-ampullary region a phase III trial of the EORTC GITCCG (Abstr. 1239). Proceedings of the Annual Meeting ECCO 9 . Eur J Cancer. 33:(Suppl. 8):1997;S274.
14. Bakkevold K.E., Arnesjo B., Dahl O., et al. Adjuvant combination chemotherapy (AMF) following radical resection of carcinoma of the pancreas and papilla of Vater results of a controlled, prospective, randomized multicenter study . Eur J Cancer. 29A:1995;698-703.
15. Mini E., Trave F., Rustum Y.M., et al. Enhancement of the antitumor effects of 5-fluorouracil by folinic acid. Pharmacol Ther. 47:1990;1-19.
16. Machover D., Goldschmidt E., Chollet P., et al. Treatment of advanced colorectal cancer and gastric adenocarcinoma with 5-fluorouracil and high-dose folinic acid. J Clin Oncol. 4:1986;685-696.
17. Arbuck S.G., Douglass H.O. Jr, Nava H.R., et al. Progress report on studies of FAM-CF for gastric cancer and intraperitoneal administration of 5-FU/CF followed by cisplatin. McGuire J., Rustum Y.M. The expanding role of folates and fluoropyrimidines in cancer chemotherapy. 1988;285-293 Plenum Press, New York.
18. André T., Lotz J.P., Bouleuc C., et al. Phase II trial of 5-fluorouracil, leucovorin and cisplatin for treatment of advanced pancreatic adenocarcinoma. Ann Oncol. 7:1996;173-178.
19. Rougier P., Ducreux M., Douillard J.Y., et al. Efficacy of 5FU+cisplatin (FUP) compared to bolus 5FU (FU) in advanced pancreatic carcinoma (APC) a randomized trial from the French Anticancer Centers Digestive Group (FNLCCDG) . (Abstr.) Proc Am Soc Clin Oncol. 18:1999;247a.
20. Sobin L.H., Wittekind Ch. UICC TNM classification of malignant tumours. 5th ed. 1997;87-90 Wiley-Liss, New York.
21. World Health Organization: WHO Handbook for Reporting Results of Cancer Treatment. WHO Offset Publication no. 48. Geneva: World Health Organization, 1979.
22. Kaplan E.L., Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 53:1958;457-481.
23. Louvet C., Hammel P., André T., et al. Multicenter phase II study in advanced pancreatic adenocarcinoma patients treated with a combination of leucovorin, 5FU bolus and infusion, and gemcitabine (FOLFUGEM regimen). (Abstr.) Proc Am Soc Clin Oncol. 18:1999;275a.
24. Rougier P., Zarba J.J., Ducreux M., et al. Phase II study of cisplatin and 120-hour continuous infusion of 5-fluorouracil in patients with advanced pancreatic adenocarcinoma. Ann Oncol. 4:1993;333-336.
25. Nicolson M., Webb A., Cunningham D., et al. Cisplatin and protracted venous infusion 5-fluorouracil (CF), good symptom relief with low toxicity in advanced pancreatic carcinoma. Ann Oncol. 6:1995;801-804.
26. Raymond E., de Gramont A., Louvet C., et al. Clinical benefit with cisplatin, hydroxyurea and 5-fluorouracil/leucovorin in advanced pancreatic adenocarcinoma. Eur J Cancer. 33:1997;696-697.
27. Gunderson L.L., Shipley W.U., Kopelson G. Pancreatic and hepatobiliary cancer. Perez C.A., Brady L.W. Principle and practice of radiation oncology. 1st edn. 1987;801-812 Lippincott, Philadelphia.
28. Nagakawa T., Kobayashi H., Ueno K., et al. Clinical study of lymphatic flow to the paraaortic lymph nodes in carcinoma of the head of the pancreas. Cancer. 73:1994;1155-1162.
29. Whittington R., Neuberg D., Tester W.J., et al. Protracted intravenous fluorouracil infusion with radiation therapy in the management of localized pancreaticobiliary carcinoma a phase I ECOG trial . J Clin Oncol. 13:1995;227-232.
30. Hoffman P.H., Lipitz S., Pisansky T. Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcima of the pancreas an Eastern Cooperative Oncology Group Study . J Clin Oncol. 16:1998;317-323.
31. Nguyen T.D., Theobald S., Rougier P., et al. Simultaneous high-dose external irradiation and daily cisplatin in unresectable, non-metastatic adenocarcinoma of the pancreas a phase I-II study . Radiother Oncol. 45:1997;129-132.
32. Moertel C.G., Childs D.S., Reitemeir R.J., et al. Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet. 2:1969;865-867.
33. Moertel C.G., Frytak S., Hahn R.G., et al. Therapy of locally unresectable pancreatic carcinoma a randomized comparison of high dose (60 Gy) radiation alone, moderate dose radiation (40 Gy + 5FU), and high dose radiation + 5FU . Cancer. 48:1981;1705-1710.
34. Treatment of locally unresectable carcinoma of the pancreas comparison of combined modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone . J Natl Cancer Inst. 80:1988;751-755.
35. White R., Lee C., Anscher M., et al. Preoperative chemoradiation for patients with locally advanced adenocarcinoma of the pancreas. Ann Surg Oncol. 6:1999;38-45.