Simultaneous high-dose external irradiation and daily cisplatin in unresectable, non-metastatic adenocarcinoma of the pancreas: A phase I-II study

Radiotherapy and Oncology

Volumn 45, Issue 2, 1997, Pages 129-132

  Nguyen, Tan D ^a   Theobald, Serge ^a   Rougier, Philippe ^b   Ducreux, Michel ^b   Lusinchi, Antoine ^b   Bardet, Etienne ^c   Eymard, Jean Christophe ^a   Conroy, Thierry ^d   Francois, Eric ^e   Seitz, Jean François ^f   Bugat, Roland ^g   Ychou, Marc ^h  

^a INSTITUT JEAN GODINOT   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c CENTRE RENÉ GAUDUCHEAU   (France)

^d CENTRE ALEXIS VAUTRIN   (France)

^e CENTRE ANTOINE LACASSAGNE   (France)

^f INSTITUT PAOLI CALMETTES   (France)

^g INSTITUT CLAUDIUS REGAUD   (France)

^h CENTRE VAL D AURELLE   (France)

Author keywords

Adenocarcinoma; Cisplatin; High dose external irradiation

Indexed keywords

CISPLATIN;

ADULT; AGED; ARTICLE; BLOOD TOXICITY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; FEMALE; GASTROINTESTINAL TOXICITY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MULTICENTER STUDY; PANCREAS ADENOCARCINOMA; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC AGENTS; CISPLATIN; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; PANCREATIC NEOPLASMS; RADIOTHERAPY, HIGH-ENERGY; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 0031282141     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(97)00116-3     Document Type: Article

References (18)

1. [1] Begg, A., Bohlken, S. and Bartelink, H. The effect of CDDP on the repair of radiation damage in RIF1 mouse tumors in vivo. Radiother. Oncol. 15: 79-91, 1989.
2. [2] Benichou, J., Bellissant, E. and Chastang, C. Analysis of phase II clinical trials in haematology and oncology: comparison of the triangular test to the usual methods. Stat. Med. 10: 989-990, 1991.
3. [3] Carter, S.K. Clinical trials in cancer chemotherapy. Cancer 40: 544-557, 1977.
4. [4] Dobelbower, R.R., Borgelt, B.B., Suntharalingam, L. et al. Pancreatic carcinoma treated with high dose small volume irradiation. Cancer 37: 1087-1092, 1978.
5. [5] Castro Intestinal Tumor Study Group. Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (60 Gy) radiation alone, moderate dose radiation (40 Gy + 5 Fu) and high dose radiation + 5 Fu. Cancer 48: 1705-1710, 1981.
6. [6] Glimelius, B., Hoffman, K., Jjoden, P.O., Jacobsson, G. Sellstrom, H., Enander, L.K., Linne, T. and Svensson, C. Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Ann. Oncol. 7: 593-600, 1996.
7. [7] Haslam, J.B., Cavanaugh, P.J. and Stroup, S.L. Radiation therapy in the treatment of irresectable carcinoma of the pancreas. Cancer 32: 1341-1345, 1973.
8. [8] Jones, D.R. and Whitehead, J. Sequential forms of the logrank and modified Wilcoxon test for censored data. Biometrika 66: 105-113, 1979.
9. [9] Milano, G., Troger, V., Courdi, A., Chauvel, P. and Lagrange, J.L., Pharmacokinetics of CDDP given at a daily dose as a radiosensitizer. Cancer Chemother. Pharmacol. 27: 55-59, 1990.
10. [10] Nguyen, T.D., Bugat, R. and Combes, P.F. Postoperative irradiation of the head of the pancreas area. Cancer 50: 53-56, 1982.
11. [11] Niederhuber, J.E., Brennan, M.F. and Menck, H.R. The national cancer data base report on pancreatic cancer. Cancer 76: 1672-1677, 1995.
12. [12] Palmer, K.R., Kerr, M., Knowles, G. et al. Chemotherapy prolongs survival in inoperable pancreatic carcinoma. Br. J. Surg. 81: 882-885, 1994.
13. [13] Rougier, Ph., Zarba, J.J., Ducreux, M. et al. Phase II study of CDDP and 120 hour continuous infusion of 5 fluorouracil in patients with advanced pancreatic carcinoma. Ann. Oncol. 4: 333-336, 1993.
14. [14] Shaake-Koenig, C., Maat, B., Van Houtte, P. et al. Radiotherapy combined with CDDP in inoperable non small cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 19: 967-972, 1990.
15. [15] Van Cutsem, A. and Fevery, J. Pancreatic cancer: a plea for more trials. Eur. J. Cancer 31: 869-870, 1995.
16. [16] Wagener, D., Rougier, Ph., Wils, J., Duez, N. and Buyse, M. Combined Chemotherapy for Locally Advanced Pancreatic Cancer. ASCO Proceedings, p. 477, 1992.
17. [17] Whitehead, J. and Jones, D.R. The analysis of sequential clinical trials. Biometrika 66: 443-452, 1979.
18. [18] Wils, J.A., Kok, T., Wagener, Th., Selleslags, J. and Duez, N. Activity of CDDP in adenocarcinoma of pancreas. Eur. J. Cancer 2: 203-204, 1993.