Cobalamin, folate, methylmalonic acid, homocysteine, and gastritis markers in dementia

Dementia and Geriatric Cognitive Disorders

Volumn 16, Issue 4, 2003, Pages 269-275

  Nägga, Katarina ^a   Rajani, R ^a   Mardh E ^a   Borch, K ^a   Mardh S ^a   Marcusson, J ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cobalamin; Dementia; Folate; Gastritis; Homocysteine; Methylmalonic acid

Indexed keywords

ANTIBODY; COBALAMIN; FOLIC ACID; HOMOCYSTEINE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; INTRINSIC FACTOR; MARKER; METHYLMALONIC ACID;

ADULT; AGED; ALZHEIMER DISEASE; ANTIBODY BLOOD LEVEL; ARTICLE; BLOOD LEVEL; COGNITIVE DEFECT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEMENTIA; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; GASTRITIS; HELICOBACTER PYLORI; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MULTIINFARCT DEMENTIA; PRIORITY JOURNAL; VASCULAR LESION; VITAMIN DEFICIENCY;

BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DEMENTIA; FOLIC ACID; GASTRITIS; HOMOCYSTEINE; HUMANS; METHYLMALONIC ACID; MIDDLE AGED; RISK FACTORS; VITAMIN B 12;

EID: 17544385370     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000072812     Document Type: Article

References (55)

1. 12) handling. Drugs Aging 1998;12:277-292.
2. Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH: Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994;60:2-11.
3. 12 deficiency in the elderly: Current dilemmas. Am J Clin Nutr 1997;66:741-749.
4. 12 in Alzheimer-type dementia. Age Ageing 1984;13:101-105.
5. 12 levels in serum and cerebrospinal fluid of people with Alzheimer's disease. Acta Psychiatr Scand 1990;82:327-329.
6. 12 deficiency. Age Ageing 1994;23:334-337.
7. 12 levels related to high activity of platelet MAO in patients with dementia disorders. A retrospective study. Acta Psychiatr Scand 1988;78:451-457.
8. Nägga K, Marcusson J: Associated physical disease in a demented population. Aging (Milano) 1998;10:440-444.
9. 6 occur commonly in elderly people. Am J Clin Nutr 1993; 58:468-476.
10. Allen RH, Stabler SP, Savage DG, Lindenbaum J: Diagnosis of cobalamin deficiency. 1. Usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990;34:90-98.
11. Lindgren A: On the Diagnosis of Cobalamin Malabsorption - With Special Reference to the Identification of Patients in Whom Substitution Treatment Is Warranted; thesis, Gotheburg, 1998.
12. Rasmussen K, Vyberg B, Pedersen KO, Brochner-Mortensen J: Methylmalonic acid in renal insufficiency: Evidence of accumulation and implications for diagnosis of cobalamin deficiency. Clin Chem 1990;36:1523-1524.
13. Moelby L, Rasmussen K, Rasmussen HH: Serum methylmalonic acid in uraemia. Scand J Clin Lab Invest 1992;52:351-354.
14. Hvas AM, Juul S, Gerdes LU, Nexø E: The marker of cobalamin deficiency, plasma methylmalonic acid, correlates to plasma creatinine. J Intern Med 2000;247:507-512.
15. 12 deficiency and dementia. Int J Geriatr Psychiatry 1996;11:851-858.
16. Lehmann M, Gottfries C, Regland B: Identification of cognitive impairment in the elderly: Homocysteine is an early marker. Dement Geriatr Cogn Disord 1999;10:12-20.
17. McCaddon A, Hudson P, Davies G, Hughes A, Williams JHH, Wilkinson C: Homocysteine and cognitive decline in healthy elderly. Dement Geriatr Cogn Disord 2001;12:309-313.
18. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PWF, Wolf PA: Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-483.
19. Selhub J, Jacques P, Wilson P, Rush D, Rosenberg I: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993;270:2693-2698.
20. Stampfer M, Willett W: Homocysteine and marginal vitamin deficiency. The importance of adequate vitamin intake. JAMA 1993;270:2726-2727.
21. Carmel R, Gott P, Waters C, Cairo K, Green R, Bondareff W, DeGiorgio C, Cummings J, Jacobsen D, Buckwalter G, Henderson V: The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities. Eur J Haematol 1995;54:245-253.
22. 12 deficiency in the elderly. Annu Rev Nutr 1999;19:357-377.
23. Regland B, Gottfries C-G, Lindstedt G: Dementia patients with low serum cobalamin concentration: Relationship to atrophic gastritis. Aging (Milano) 1992;4:35-41.
24. Sipponen P, Hyvärinen H: Role of Helicobacter pylori in the pathogenesis of gastritis, peptic ulcer and gastric cancer. Scand J Gastroenterol Suppl 1993;196:3-6.
25. Dooley CP, Cohen H, Fitzgibbons PL, Bauer M, Appleman MD, Perez-Perez GI, Blaser MJ: Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med 1989;321:1562-1566.
26. Watanabe Y, Ozasa K, Higashi A, Hayashi K, Mizuno S, Mukai M, Inokuchi H, Miki K, Kawai K: Helicobacter pylori infection and atrophic gastritis. A case-control study in a rural town in Japan. J Clin Gastroenterol 1997;25:391-394.
27. Uibo R, Salupere V, Krohn K: Autoimmune reactions to gastric mucosa in chronic gastritis: A review. Scand J Gastroenterol Suppl 1991;186:11-15.
28. Karlsson FA, Burman P, Lööf L, Mårdh S: Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+,K+-adenosine triphosphatase of the stomach. J Clin Invest 1988;81:475-479.
29. Saltzman JR, Russell RM: The aging gut: Nutritional issues. Gastroenterol Clin North Am 1998;27:309-324.
30. Borch K, Jönsson K-Å, Petersson F, Redeén S, Mårdh S, Franzén LE: Prevalence of gastritoduodenitis and Helicobacter pylori infection in a general population sample: Relations to symptomatology and life style. Dig Dis Sci 2000;45:1322-1329.
31. World Health Organization: ICD-10 Classification of Mental and Behavioural Disorders. Geneva, World Health Organization, 1993.
32. Folstein M, Folstein S, McHugh P: Mini-mental state: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
33. Nägga K, Gottfries J, Blennow K, Marcusson J: Cerebrospinal fluid phospho-tau, total tau and beta-amyloid (1-42) in the differentiation between Alzheimer's disease and vascular dementia. Dement Geriatr Cogn Disord 2002;14:183-190.
34. Andersson A, Brattström L, Isaksson A, Israelsson B, Hultberg B: Determination of homocysteine in plasma by ion-exchange chromatography. Scand J Clin Lab Invest 1989;49:445-449.
35. Andersson A: Studies on the Determination and the Metabolism of Homocysteine in Man; thesis, Lund, 1993.
36. Ueland PM, Refsum H, Stabler PS, Malinow MR, Andersson A, Allen R: Total homocysteine in plasma or serum: Methods and clinical applications. Clin Chem 1993;39:1764-1779.
37. Rasmussen K: Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method. Clin Chem 1989;35:260-264.
38. Lindenbaum J, Savage DG, Stabler SP, Allen RH: Diagnosis of cobalamin deficiency. 2. Relative sensitivities of serum cobalamin, methyl-malonic acid, and total homocysteine concentrations. Am J Hematol 1990;34:99-107.
39. Mårdh E, Mårdh S, Mårdh B, Borch K: Diagnosis of gastritis by means of a combination of serological analyses. Clin Chim Acta 2002;320: 17-27.
40. Mårdh S, Ma J, Song Y-H, Aly A, Henriksson K: Occurrence of autoantibodies against intrinsic factor, H,K-ATPase, and pepsinogen in atrophic gastritis and rheumatoid arthritis. Scand J Gastroenterol 1991;26:1089-1096.
41. SPSS. Chicago, SPSS, 2000.
42. 12 andfolate in relation to the development of Alzheimer's disease. Neurology 2001;56:1188-1194.
43. Nurk E, Tell GS, Nygård O, Refsum H, Ueland PM, Vollset SE: Plasma total homocysteine is influenced by prandial status in humans: The Hordaland Homocysteine Study. J Nutr 2001;131:1214-1216.
44. Thirup P, Ekelund S: Day-to-day, postprandial, and orthostatic variation of total plasma homocysteine. Clin Chem 1999;45:1280-1283.
45. Nilsson K, Gustafson L, Fäldt R, Andersson A, Brattström L, Lindgren A, Israelsson B, Hultberg B: Hyperhomocysteinaemia - A common finding in a psychogeriatric population. Eur J Clin Invest 1996;26:853-859.
46. Nilsson K, Gustafson L, Hultberg B: Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamins and folates in a psychogeriatric population. Dement Geriatr Cogn Disord 1999;10:476-482.
47. Nilsson K, Gustafson L, Hultberg B: Optimal use of markers for cobalamin and folate status in a psychogeriatric population. Int J Geriatr Psychiatry 2002;17:919-925.
48. Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ: Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr 2002;75:908-913.
49. Santosh-Kumar C, Hassell K, Deutsch J, Kolhouse J: Are neuropsychiatric manifestations of folate, cobalamin and pyridoxine deficiency mediated through imbalances in excitatory sulfur amino acids? Med Hypotheses 1994;43:239-244.
50. Boushey CJ, Beresford SA, Omenn GS, Motulsky GA: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-1057.
51. Refsum H, Ueland PM, Nygård O, Vollset SE: Homocysteine and cardiovascular disease. Annu Rev Med 1998;49:31-62.
52. Eikelboom JW, Lonn E, Genest J Jr, Hankey G, Yusuf S: Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence. Ann Intern Med 1999;131:363-375.
53. Bostom AG, Rosenberg IH, Silbershatz H, Jacques PF, Selhub J, D'Agostino RB, Wilson PW, Wolf PA: Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: The Framingham Study. Ann Intern Med 1999;131:352-355.
54. McIlroy SP, Dynan KB, Lawson JT, Patterson CC, Passmore AP: Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer's disease in Northern Ireland. Stroke 2002;33:2351-2356.
55. Clarke R, Daly L, Robinson K, Naughten E, Calahane S, Fowler B, Graham I: Hyperhomocysteinemia: An independent risk factor for vascular disease. N Engl J Med 1991;324:1149-1155.