Co-operative regulation of ligand binding to melanocortin receptor subtypes: Evidence for interacting binding sites

European Journal of Pharmacology

Volumn 512, Issue 2-3, 2005, Pages 85-95

  Kopanchuk, Sergei ^a,b   Veiksina, Santa ^a   Petrovska, Ramona ^a   Mutule, Ilze ^a   Szardenings, Michael ^a   Rinken, Ago ^b   Wikberg, Jarl E S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF TARTU   (Estonia)

Author keywords

Calcium; Cooperativity; Melanocortin receptor; Melanocyte stimulating hormone; Radioligand binding; Sf9 cells

Indexed keywords

ALPHA INTERMEDIN; ALPHA INTERMEDIN DERIVATIVE; ALPHA INTERMEDIN[4 NORLEUCINE 7 DEXTRO PHENYLALANINE]; BETA INTERMEDIN[11-22][11 (N ACETYLCYSTEINE) 14 [3 (2 NAPHTHYL) DEXTRO ALANINE] 18 CYSTEINE 22 ASPARTIC ACID AMIDE] 11,18 CYCLIC DISULFIDE; CALCIUM ION; GAMMA INTERMEDIN; GAMMA MELANOCYTE STIMULATING HORMONE[4 NORLEUCINE]; GAMMA MELANOCYTE STIMULATING HORMONE[LYSINE]; HS 024; HS 131; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 5 RECEPTOR; MS 05; PEPTIDE HORMONE; SERYLSERYLISOLEUCYLISOLEUCYLSERYLHISTIDYLPHENYLALANYLARGINYLTRYPTOPHYL GLYCYLLYSYLPROLYLVALINAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; DRUG RECEPTOR BINDING; INSECT CELL; LIGAND BINDING; MELANOMA CELL; NONHUMAN; PRIORITY JOURNAL;

EID: 17444407862     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.02.021     Document Type: Article

References (40)

1. L.F. Agnati, S. Ferre, C. Lluis, R. Franco, and K. Fuxe Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons Pharmacol. Rev. 55 2003 509 550
2. P. Andersson, A. Boman, E. Seifert, A. Skottner, and T. Lundstedt Ligands to the melanocortin receptors Exp. Opinion Ther. Patents 11 2001 1583 1592
3. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
4. W. Chen, T.S. Shields, P.J. Stork, and R.D. Cone A colorimetric assay for measuring activation of Gs- and Gq-coupled signaling pathways Anal. Biochem. 226 1995 349 354
5. V. Chhajlani, and J.E.S. Wikberg Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA FEBS Lett. 309 1992 417 420
6. V. Chhajlani, R. Muceniece, and J.E.S. Wikberg Molecular cloning of a novel human melanocortin receptor Biochem. Biophys. Res. Commun. 195 1993 866 873
7. D. Colquhoun The relation between classical and cooperative models for drug action E. Rang Drug Receptors 1973 MacMillan London 149 182
8. K.U. Dee, and M.L. Shuler Optimization of an assay for baculovirus titer and design of regimens for the synchronous infection of insect cells Biotechnol. Prog. 13 1997 14 24
9. A. de Lean, J. Stadel, and R.J. Lefkowitz A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled b-adrenergic receptor J. Biol. Chem. 255 1980 7108 7117
10. V. Dolby, A. Collen, A. Lundqvist, and P. Cronet Overexpression and functional characterisation of the human melanocortin 4 receptor in Sf9 cells Protein Expr. Purif. 37 2004 455 461
11. N.R. Draper, and W.G. Hunter The use of prior distributions in the design of experiments for parameter estimation in non-linear situations: multiresponse case Biometrika 54 1967 662 665
12. I. Gantz, Y. Konda, T. Tashiro, Y. Shimoto, H. Miwa, G. Munzert, S.J. Watson, J. Delvalle, and T. Yamada Molecular cloning of a novel melanocortin receptor J. Biol. Chem. 268 1993 8246 8250
13. I. Gantz, H. Miwa, Y. Konda, Y. Shimoto, T. Tashiro, S.J. Watson, J. Delvalle, and T. Yamada Molecular cloning, expression, and gene localization of a fourth melanocortin receptor J. Biol. Chem. 268 1993 15174 15179
14. J.E. Gerst, J. Sole, and Y. Salomon Dual regulation of beta-melanotropin receptor function and adenylate cyclase by calcium and guanosine nucleotides in the M2R melanoma cell line Mol. Pharmacol. 31 1987 81 88
15. A. Kask, F. Mutulis, R. Muceniece, R. Pähkla, I. Mutule, J.E.S. Wikberg, L. Rägo, and H.B. Schiöth Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo Endocrinology 139 1998 5006 5014
16. J. Lindblom, B. Opmane, F. Mutulis, I. Mutule, R. Petrovska, V. Klusa, L. Bergstrom, and J.E.S. Wikberg The MC4 receptor mediates alpha-MSH induced release of nucleus accumbens dopamine NeuroReport 12 2001 2155 2158
17. V.A. Luckow, S.C. Lee, G.F. Barry, and P.O. Olins Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in Escherichia coli J. Virol. 67 1993 4566 4579
18. A. Maggi, D.C. U'Prichard, and S.J. Enna Beta-adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system Science 207 1980 645 647
19. I. Mandrika, R. Petrovska, and J.E.S. Wikberg Melanocortin receptors form constitutive homo- and heterodimers Biochem. Biophys. Res. Commun. 326 2005 349 354
20. R. Mattera, B.J. Pitts, M.L. Entman, and L. Birnbaumer Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting J. Biol. Chem. 260 1985 7410 7421
21. K.G. Mountjoy, L.S. Robbins, M.T. Mortrud, and R.D. Cone The cloning of a family of genes that encode the melanocortin receptors Science 257 1992 1248 1251
22. F. Mutulis, I. Mutule, M. Lapins, and J.E. Wikberg Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors Bioorg. Med. Chem. Lett. 12 2002 1035 1038
23. F. Mutulis, I. Mutule, and J.E. Wikberg N-alkylaminoacids and their derivatives interact with melanocortin receptors Bioorg. Med. Chem. Lett. 12 2002 1039 1042
24. D.R. O'Reilly, L.K. Miller, and V.A. Luckow Baculovirus Expression Vectors: A Laboratory Manual 1992 Freeman New York
25. C.D. Rios, B.A. Jordan, I. Gomes, and L.A. Devi G-protein-coupled receptor dimerization: modulation of receptor function Pharmacol. Ther. 92 2001 71 87
26. W.H. Rostene, C.T. Fischette, and B.S. McEwen Modulation by vasoactive intestinal peptide (VIP) of serotonin receptors in membranes from rat hippocampus J. Neurosci. 3 1983 2414 2419
27. Y. Salomon Melanocortin receptors: targets for control by extracellular calcium Mol. Cell. Endocrinol. 70 1990 139 145
28. H.B. Schiöth, R. Muceniece, J.E. Wikberg, and V. Chhajlani Characterisation of melanocortin receptor subtypes by radioligand binding analysis Eur. J. Pharmacol. 288 1995 311 317
29. H.B. Schiöth, V. Chhajlani, R. Muceniece, V. Klusa, and J.E. Wikberg Major pharmacological distinction of the ACTH receptor from other melanocortin receptors Life Sci. 59 1996 797 801
30. H.B. Schiöth, R. Muceniece, and J.E. Wikberg Characterisation of the melanocortin 4 receptor by radioligand binding Pharmacol. Toxicol. 79 1996 161 165
31. H.B. Schiöth, R. Muceniece, M. Szardenings, P. Prusis, G. Lindeberg, S.D. Sharma, V.J. Hruby, and J.E.S. Wikberg Characterisation of D117A and H260A mutations in the melanocortin 1 receptor Mol. Cell. Endocrinol. 126 1997 213 219
32. H.B. Schiöth, R. Muceniece, and J.E.S. Wikberg Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes Neuropeptides 31 1997 565 571
33. H.B. Schiöth, F. Mutulis, R. Muceniece, P. Prusis, and J.E.S. Wikberg Discovery of novel melanocortin 4 receptor selective MSH analogues Br. J. Pharmacol. 124 1998 75 82
34. G.E. Smith, G. Ju, B.L. Ericson, J. Moschera, H.W. Lahm, R. Chizzonite, and M.D. Summers Modification and secretion of human interleukin 2 produced in insect cells by a baculovirus expression vector Proc. Natl. Acad. Sci. U. S. A. 82 1985 8404 8408
35. 1 receptor Peptides 21 2000 239 243
36. J.E.S. Wikberg Melanocortin receptors: new opportunities in drug discovery Exp. Opinion Ther. Patents 11 2001 61 76
37. 3H]-idazoxan binding sites (I-receptors) occurs to interacting or interconvertible affinity forms of the receptor Pharmacol. Toxicol. 70 1992 208 219
38. J.E.S. Wikberg, M. Dambrova, S. Uhlen, and P. Prusis Conditions for biphasic competition curves in radioligand binding for ligands subjected to metabolic transformation Biochem. Pharmacol. 56 1998 1129 1137
39. J.E. Wikberg, R. Muceniece, I. Mandrika, P. Prusis, J. Lindblom, C. Post, and A. Skottner New aspects on the melanocortins and their receptors Pharmacol. Res. 42 2000 393 420
40. K.A. Wreggett, and A. de Lean The ternary complex model. Its properties and application to ligand interactions with the D2-dopamine receptor of the anterior pituitary gland Mol. Pharmacol. 26 1984 214 227