RET rearrangements in papillary thyroid carcinomas and adenomas detected by interphase FISH

Cytogenetics and Cell Genetics

Volumn 88, Issue 1-2, 2000, Pages 56-61

  Cinti, R ^a   Yin, L ^b   Ilc, K ^b   Berger, N ^c   Basolo, F ^d   Cuccato, S ^d   Giannini, R ^d   Torre, G ^a   Miccoli, P ^d   Amati, P ^e   Romeo, Giovanni ^a,b   Corvi, R ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c Clinique Endocrinologique   (France)

^d UNIVERSITY OF PISA   (Italy)

^e POITIERS UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL NUCLEUS; CENTROMERE; CHROMOSOME 10; CHROMOSOME 17; CHROMOSOME INVERSION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; COSMID; FLUORESCENCE IN SITU HYBRIDIZATION; GENE ACTIVATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; INTERPHASE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TETRASOMY; THYROID ADENOMA; THYROID PAPILLARY CARCINOMA; TRISOMY;

EID: 17344389105     PISSN: 03010171     EISSN: None     Source Type: Journal    
DOI: 10.1159/000015485     Document Type: Article

References (33)

1. Bongarzone I, Fugazzola L, Vigneri P, Mariani L, Mondellini P, Pacini F, Basolo F, Pinchera A, Pilotti S, Pierotti M: A. Age-related activation of the tyrosine kinase receptor protooncogenes RET and NTRKI in papillary thyroid carcinoma. J clin Endoer Metab 81:2006-2009 (1996).
2. Bongarzone I, Monzini N, Borrello MG, Carcana C, Ferraresi G, Arighi E, Mondellini P, Della Porta G, Pierotti MA: Molecular characterization of a thyroid tumour-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit R1α of cyclic AMP-dependent protein kinase A. Mol cell Biol 13:358-366 (1993).
3. Estalilla O, Rintels P, Mark HFL: Trisomy 10 in leukemia. Cancer Genet Cytogenet 101:68-71 (1998).
4. Fugazzola L, Pierotti MA, ViganÒ E, Pacini F, Vorontsova TV, Bongarzone I: Molecular and biochemical analysis of RET/PTC4. a novel oncogenic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer. Oncogene 13:1093-1097 (1996).
5. Grieco M, Santoro M, Berlingieri MT, Melillo RM, Donghi R, Bongarzone I, Pierotti MA, Della Porta G, Fusco A, Vecchio G: PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60:557-563 (1990).
6. Hopman AHN, Moesker O, Smeets AWGB, Pauwels RPE, Vooijs GP, Ramaeker FCS: Numerical chromosome 1, 7, 9, and 11 aberrations in bladder cancer detected by in situ hybridization. Cancer Res 51:644-651 (1991).
7. Ishizaka Y, Kobayashi S, Ushijima T, Hirohashi S, Sugimura T, Nagao M: Detection of retTPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method. Oncogene 6:1667-1672 (1991).
8. Jenkins RB, Hay ID, Herath JF, Shultz CG, Spurbeck JI, Grant CS, Goellner JR, Dewald GW: Frequent occurrence of cytogenetic abnormalities in sporadic nonmedullary thyroid carcinoma. Cancer 66:1213-1220 (1990).
9. Johannessen JV, Sobrinho-Simoes, M, Lindmo T, Tangen KO, Kaalhus O, Brennhovd IO: Anomalous papillary carcinoma of the thyroid. Cancer 51:1462-1467 (1983).
10. Jones E, Zhu XL, Rohr LR, Stephenson RA, Brothman AR: Aneusomy of chromosomes 7 and 17 detected by FISH in prostate cancer and the effects of selection in vitro. Genes Chrom Cancer 11:163-170 (1994).
11. Jossart GH, Greulich KM, Siperstein AE, Duh Q, Clark OH, Weier HUG: Molecular and cytogenetic characterization of a t(1;10;21) translocation in the human papillary thyroid cancer cell line TPC-1 expressing the ret/H4 chimeric transcript. Surgery 118:1018-1023 (1995).
12. Jossarl GH, O'Brien B, Cheng JF, Tong Q, Jhiang SM, Duh Q, Clark OH, Weier, HUG: A novel multicolor hybridization scheme applied to localization of a transcribed sequence (D1OS170/H4) and deletion mapping in the thyroid cancer cell line TPC-1. Cytogenet Cell Genet 75:254-257 (1996).
13. Klugbauer S, Demidchik EP, Lengfelder E, Rabes HM: Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5. Cancer Res 58:198-203 (1998).
14. Klugbauer S, Lengfelder E, Demidchik EP, Rabes HM: High prevalence of RET rearrangement in thyroid tumours of children from Belarus after the Chernobyl reactor accident. Oncogene 11:2459-2467 (1995).
15. Klugbauer S, Rabes HM: The transcription coactivator HTIFI and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. Oncogene 18:4388-4393 (1999).
16. Langer PR, Waldropm AA, Ward DC: Enzymatic synthesis of biolin-labeled polynudeotides: novel nucleic acid affinity probes. Proc natl Acad Sci, USA 78:6633-6637 (1981).
17. Lehmann L, Greulich KM, Zitzelsberger H, Negele T. Spelsber F, Bauchinger M, Weicr HUG: Cytogenetic and molecular genetic characterization of a chromosome 2 rearrangement in a case of human papillary thyroid carcinoma with radiation history. Cancer Genet Cytogenet 96:30-36 (1997).
18. Matsuyama H, Bergerheim USR, Nilsson I, Pan Y, Skoog L, Tribukait B, Ekman P: Nonrandom numerical aberrations of chromosomes 7, 9, and 10 in DNA-diploid bladder cancer. Cancer Genet Cytogenet 77:118-124 (1994).
19. Meloni A, Pontes JE, Sandberg AA: Trisomy 10 in renal cell carcinoma. Cancer Genet Cytogenet 51:137-138 (1991).
20. Minoletti F, Butti MG, Coronelli S, Miozzo M. Sozzi G, Pilotti S, Tunnacliffe A, Pierotti MA, Bongarzone I: The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2. Genes Chrom Cancer 11:51-57 (1994).
21. Nakata T, Kitamura Y, Shimizu K, Tanaka S, Fujimori M, Yokoyama S, Ito K, Emi M: Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma. Genes Chrom Cancer 25:97-103 (1999).
22. Nikiforov YE, Rowland JM, Bove KE, Monforte-Munoz H, Fagin JA: Distinct pattern of ret oncogene rearrangements in morphological variants of radiation induced and sporadic thyroid papillary carcinomas in children. Cancer Res 57:1690-1694 (1997).
23. Pasini B, Ceccherini I, Romeo G: RET mutations in human disease. Trends Genet 12:138-144 (1996).
24. Pasini B, Hofstra RMV, Yin L, Bocciardi R, Santamaria G, Grootscholten PM, Ceccherini I, Patrone G, Priolo M, Buys CH, Romeo G: The physical map of the human RET proto-oncogene. Oncogene 11:1737-1743 (1995).
25. Pierotti MA, Santoro M, Jenkins RB, Sozzi G, Bongarzone I, Grieco M, Monzini, N, Miozzo M, Herrmann MA, Fusco A, Hay ID, Della Porta G, Vecchio G: Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC. Proc nail Acad Sci, USA 89:1616-1620 (1992).
26. Pinkel D, Straume T, Gray JW: Cytogenetic analysis using quantitative, high sensitivity, fluorescence hybridization. Proc natl Acad Sci, USA 83:2934-2938 (1986).
27. Santoro M, Carlomagno F, Hay ID, Herrmann MA, Grieco M, Melillo R, Pierotti MA, Bongarzone 1, Delia Porta G, Berger N, Peix JL, Paulin C, Fabien N, Vecchio G, Jenkins RB, Fusco A: Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. J clin Invest 89:1517-1522 (1992).
28. Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A: Molecular characterization of RET/PTC3; a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma. Oncogene 9:509-516 (1994).
29. Sirchia SM, Pariani S, Rossella F, Garagiola I, De Andreis C, Bulfamante G, Zannoni E, Radaelli U, Simoni G: Cytogenctic abnormalities and microsatellite instability in endometrial adenocarcinoma. Cancer Genet Cytogenet 94:113-119 (1997).
30. Sozzi G, Bongarzone I, Miozzo M, Borrello MG, Butti MG, Pilotti S, Della Porta G, Pierotti MA: A 1(10:17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma. Genes Chrom Cancer 9:244-250 (1994).
31. Sugg SL, Zheng L, Rosen IB, Freeman, JL, Ezzat S, Asa SL: ret/PTC-1, -2, -3 oncogene rearrangements in human thyroid carcinomas: implications for metastatic potential? J clin Endocr Metab 81:3360-3365 (1996).
32. Viglietto G, Chiappetta G, Martinez-Tello FJ, Fukunaga FH, Tallini G, Rigopoulou D, Visconti R, Mastro A, Santoro M, Fusco A: RET/PTC oncogene activation is an early stage event in thyroid carcinogenesis. Oncogene 11:1207-1210 (1995).
33. Wada Y, Yokogi H, Moriyama-Gonda N, Shigeno K, Shiina H, Igawa M: Chromosome aberrations in renal tumours detected by fluorescence in situ hybridization. Cancer Genet Cytogenet 99:38-44 (1997).