Evidence for down-regulation of GAP-43 mRNA in Wobbler mouse spinal motoneurons by corticosterone and a 21-aminosteroid

Brain Research

Volumn 841, Issue 1-2, 1999, Pages 78-84

  González Deniselle, María Claudia ^a,b   Grillo, Claudia A ^a,b   González, Susana ^a,b   Roig, Paulina ^b   De Nicola, Alejandro F ^a,b,c  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^c Argentina   (Argentina)

Author keywords

21 Aminosteroid; Amyotrophic lateral sclerosis; GAP 43 mRNA; Glucocorticoid; In situ hybridization; Spinal cord; Wobbler mouse

Indexed keywords

21 AMINOSTEROID; CORTICOSTERONE; GLUCOCORTICOID; MESSENGER RNA; NEUROMODULIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; IN SITU HYBRIDIZATION; MALE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD MOTONEURON; SPINAL CORD VENTRAL HORN; STEROID THERAPY; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTIOXIDANTS; CORTICOSTERONE; FEMALE; GAP-43 PROTEIN; GENE EXPRESSION REGULATION; IN SITU HYBRIDIZATION; MALE; MICE; MICE, NEUROLOGIC MUTANTS; MOTOR NEURONS; POSTERIOR HORN CELLS; PREGNATRIENES; RNA, MESSENGER; SPINAL CORD; TRANSCRIPTION, GENETIC;

EID: 17344381149     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01783-7     Document Type: Article

References (28)

1. Benowitz L.I., Routtenberg A. GAP-43: an intrinsic determinant of neuronal development and plasticity. Trends Neurosci. 20:1997;84-91.
2. Bowling A.C., Schulz J.B., Brown R.H., Beal M.F. Superoxide dismutase activity, oxidative damage and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J. Neurochem. 61:1993;2322-2325.
3. Chao H.M., Sakai R.R., Ma M.Y., McEwen B.S. Adrenal steroid regulation of neurotrophic factor expression in the rat hippocampus. Endocrinology. 139:1998;3112-3118.
4. Chao H.M., Spencer R.L., Sakai R.R., McEwen B.S. The expression of growth-associated protein GAP-43 mRNA in the rat hippocampus in response to adrenalectomy and aging. Mol. Cell. Neurosci. 3:1992;529-535.
5. Curtis R., Averill S., Priestley J.V., Wilkin G.P. The distribution of GAP-43 in the normal spinal cord. J. Neurocytol. 22:1993;39-50.
6. Curtis R., Green D., Lindsay R.M., Wilkin G.P. Up-regulation of GAP-43 and growth of axons in rat spinal cord after compression. J. Neurocytol. 22:1993;51-64.
7. De La Monte S.M., Ng S.-C., Hsu D.W. Aberrant GAP-43 gene expression in Alzheimer's disease. Am. J. Pathol. 147:1995;934-946.
8. De Nicola A.F., Ferrini M., Gonzalez S.L., Gonzalez Deniselle M.C., Grillo C., Piroli G., Saravia F., de Kloet E.R. Regulation of gene expression by corticoid hormones in the brain and spinal cord. J. Steroid Biochem. Mol. Biol. 65:1998;253-272.
9. Elliott E.J., Parks D.A., Fishman P.S. Effect of proximal axotomy on GAP-43 expression in cortical neurons in the mouse. Brain Res. 755:1997;221-228.
10. Federoff H.J., Grabczyk E., Fishman M.C. Dual regulation of GAP-43 gene expression by nerve growth factor and glucocorticoids. J. Biol. Chem. 263:1988;19290-19295.
11. Gonzalez Deniselle M.C., Gonzalez S., Lima A., Wilkin G., De Nicola A.F. The 21-aminosteroid U-74389F attenuates hyperexpression of GAP-43 and NADPH-diaphorase in the spinal cord of wobbler mouse, a model for amyotrophic lateral sclerosis. Neurochem. Res. 24:1999;1-8.
12. Gonzalez Deniselle M.C., Gonzalez S., Piroli G., Ferrini M., Lima A., De Nicola A.F. Glucocorticoid receptors and actions in the spinal cord of the wobbler mouse, a model for amyotrophic lateral sclerosis. J. Steroid Biochem. Mol. Biol. 60:1997;205-213.
13. Gonzalez Deniselle M.C., Gonzalez S., Piroli G., Lima A., De Nicola A.F. The 21-aminosteroid U-74389F increases the number of glial fibrillary acidic protein-expresing astrocytes in the spinal cord of wobbler mice. Cell. Mol. Neurobiol. 16:1996;61-72.
14. +-ATPase in some spinal cord neurons after cord transection. NeuroReport. 7:1996;1041-1044.
15. Hall E.D. Neuroprotective actions of glucocorticoid and non-glucocorticoid steroids in acute neuronal injury. Cell. Mol. Neurobiol. 13:1993;415-432.
16. Hall E.D. The neuroprotective pharmacology of methylprednisolone. J. Neurosurg. 76:1992;13-22.
17. Hantaz-Ambroise D., Blondet B., Murawsky M., Rieger F. Abnormal astrocyte differentiation and deffective cellular interactions in wobbler mouse spinal cord. J. Neurocytol. 23:1994;179-192.
18. Henderson J.T., Javaheri M., Kopko S., Roder J.C. Reduction of lower motor neuron degeneration in wobbler mice by n-acetyl-L-cysteine. J. Neurosci. 16:1996;7574-7582.
19. Ikeda K., Kinoshita M., Iwasaki K., Tayaga N., Shiojima T. Lecithinized superoxide dismutase retards wobbler mouse motoneuron disease. Neuromusc. Disord. 5:1995;383-393.
20. Kage M., Ikemoto A., Akiguchi J., Kimura J., Matsumoto S., Kimura H., Tooyama I. Primary structure of GAP-43 mRNA expressed in the spinal cord of ALS patients. NeuroReport. 9:1998;1403-1406.
21. Kapfhammer J.P., Schwab M.E. Inverse paterns of myelination and GAP-43 expression in the adult CNS: neurite growth inhibitors as regulators of neuronal plasticity. J. Comp. Neurol. 340:1994;194-206.
22. Ma W., Vacca-Galloway L.L. Spiny interneurons identifed in the normal mouse spinal cord shows alterations in the Wobbelr mouse: a model for inherited motoneuron disease. Rest. Neurol. Neurosci. 4:1992;381-392.
23. Mitsumoto H., Bradley W.G. Murine motor disease (the wobbler mouse): degeneration and regeneration of the lower motor neuron. Brain Res. 105:1982;811-834.
24. Mitsumoto H., Gambetti P. Impaired slow axonal transport in wobbler mouse motor neuron disease. Ann. Neurol. 19:1986;36-43.
25. Olanow C.W. A radical hypothesis for neurodegeneration. Trends Neurosci. 16:1993;439-444.
26. Parhad I.M., Oishi R., Clarck A.W. GAP-43 gene expression is increased in anterior horn cells of amyotrophic lateral sclerosis. Ann. Neurol. 31:1992;593-597.
27. Popper P., Farber D.B., Micevych P.E., Minooofar K., Bronstein J.M. RTPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice. Exp. Neurol. 143:1997;246-254.
28. Reul J.M.H.M., de Kloet E.R. Two receptor systems for corticosterone in rat brain: microdissection and differential occupation. Endocrinology. 117:1985;2505-2512.