Glucocorticoid receptors and actions in the spinal cord of the Wobbler mouse a model for neurodegenerative diseases

Journal of Steroid Biochemistry and Molecular Biology

Volumn 60, Issue 3-4, 1997, Pages 205-213

  González Deniselle, Maria Claudia ^a,b   González, Susana ^a,b   Piroli, Gerardo ^a,b   Ferrini, Mónica ^a   Lima, Analia E ^a   De Nicola, Alejandro F ^a,b  

^a INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; DEXAMETHASONE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOCORTICOID RECEPTOR; ORNITHINE DECARBOXYLASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; HEREDITARY SPINAL MUSCULAR ATROPHY; HIPPOCAMPUS; MALE; MOUSE; NONHUMAN; RECEPTOR DOWN REGULATION; SPINAL CORD;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ASTROCYTES; CELL DIVISION; CORTICOSTERONE; DEXAMETHASONE; DISEASE MODELS, ANIMAL; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOCORTICOIDS; LUMBOSACRAL REGION; MALE; MICE; MICE, MUTANT STRAINS; NECK; ORNITHINE DECARBOXYLASE; RECEPTORS, GLUCOCORTICOID; SEX FACTORS; SPINAL CORD; SPINAL MUSCULAR ATROPHIES OF CHILDHOOD;

EID: 0343923618     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(96)00193-8     Document Type: Article

References (61)

1. Duchen L. W., Falconer D. S. and Stricht S. J.: Hereditary progressive neurogenic muscular atrophy in the mouse. J. Physiol. (Lond.) 183 (1966) 53P-55P.
2. Laage S., Zobel G. and Jockusch H.: Astrocyte overgrowth in the brain stem and spinal cord of mice affected by spinal atrophy, Wobbler. Dev. Neurosci. 10 (1988) 190-198.
3. Junier M. P., Coulpier M., Le Forestier N, Cadusseau J., Suzuki F., Peschanski M. and Dreyfus P. A.: Transforming growth factor alpha (TGF alpha) expression in degerenating motoneurons of the murine mutant Wobbler: a neuronal signal for astrogliosis?. J. Neurosci. 14 (1994) 4206-4216.
4. Gonzalez Deniselle M. C., Gonzalez S., Piroli G. G., Lima A. E. and De Nicola A. F.: The 21-aminosteroid U-74389F increases the number of glial fibrillary acidic protein-expressing astrocytes in the spinal cord of control and Wobbler mice. Cell. Molec. Neurobiol. 16 (1996) 61-72.
5. Leetsma J. E.: Animal model: motor neuron disease in the wobbler (wr/wr) mouse. Am. J. Pathol. 100 (1980) 811-814.
6. Mitsumoto H. and Bradley W. G.: Murine motor neuron disease (the Wobbler mouse): degeneration and regeneration of the lower motor neuron. Brain Res. 105 (1982) 811-834.
7. Ma W. and Vacca-Galloway L. L.: Spiny interneurons identified in the normal mouse spinal cord shows alterations in the Wobbler mouse: a model for inherited motoneuron disease. Rest. Neurol. Neurosci. 4 (1992) 381-392.
8. Yung K. K. L., Tang F. and Vacca-Galloway L. L.: Changes of neuropeptides in spinal cord and brain stem of Wobbler mouse at different stages of motoneuron disease. Neuroscience 50 (1992) 209-222.
9. De Nicola, A. F., Steroid hormones and neuronal regeneration. In Advances in Neurology, Vol. 59, ed. F. J. Seil. Raven Press, New York, 1992, pp. 199-206.
10. Reul J. M. H. M. and De Kloet E. R.: Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 117 (1985) 2505-2512.
11. Gonzalez S., Moses D. F. and De Nicola A. F.: Glucocorticoid receptors and enzyme induction in the spinal cord of rats: effects of acute transection. J. Neurochem. 54 (1990) 834-840.
12. Moses D. F., Gonzalez S., McEwen B. S. and De Nicola A. F.: Glucocorticoid type II receptors of the spinal cord show lower affinity than hippocampal type II receptors. Binding parameters obtained with different experimental protocols. Journal of Steroid Biochemistry & Molecular Biology 39 (1991) 5-12.
13. Orti E., Moses D. F., Grillo C. and De Nicola A. F.: Glucocorticoid regulation of glycerolphosphate dehydrogenase and ornithine decarboxylase in the spinal cord of the rat. J. Neurochem, 48 (1987) 425-431.
14. Braughler T. and Hall E. D.: Acute enhancement of spinal cord synaptosomal (Na, K) ATPase activity in cats following intravenous methylprednisolone. Brain Res. 219 (1981) 464-469.
15. Gonzalez S., Grillo C., De Nicola A. G., Piroli G., Angulo J., McEwen B. S. and De Nicola A. F.: Dexamethasone increases adrenalectomy-depressed (Na + K)ATPase and ouabain binding in spinal cord ventral horn. J. Neurochem. 63 (1994) 1962-1970.
16. Gonzalez S., Ferrini M., Coirini H., Gonzalez Deniselle M. C. De Nicola A. F.: Regulation of flunitrazepam binding in the dorsal horn of the spinal cord by adrenalectomy and corticosteroids. Brain Res. 589 (1992) 97-101.
17. Hall E. D.: Glucocorticoid effects on central nervous excitability and synaptic transmission. Int. Rev. Neurobiol. 23 (1982) 165-195.
18. Reder A. T., Lowy M. T., Meltzer H. Y. and Antel J. P.: Dexamethasone suppression test abnormalities in multiple sclerosis: relation to ACTH therapy. Neurology 37 (1987) 849-853.
19. Braken M. B., Shepard M. J., Collins W. F., Holford T. R., Baskin D. S., Eisenberg H. M., Flamm E. S., Leo-Summers L., Marshall L. F., Perot P. L., Piepmeir J., Sonntag V. K. H., Wagner F. C., Wilberger J. E., Winn H. R. and Young W.: Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up: results of the second National Acute Spinal Cord Injury Study. J. Neurosurg. 16 (1992) 23-31.
20. La Mantia L., Eoli M., Milanese C., Salmaggi A., Dufour A. Torri V.: Double-blind trial of dexamethasone versus methylprednisolone in multiple sclerosis acute relapses. Eur. Neurol. 34 (1994) 199-203.
21. Gonzalez S., Coirini H., Gonzalez Deniselle M. C., Gonzalez S., Calandra R. and De Nicola A. F.: Time-dependent effects of dexamethasone on glutamate binding, ornithine decarboxylase activity and polyamine levels in the transected spinal cord. Journal of Steroid Biochemistry & Molecular Biology 55 (1995) 85-92.
22. Laping N. J., Nichols N. R., Day J. R. and Finch C. E.: Corticosterone differentially regulates the bilateral response of astrocyte mRNAs in the hippocampus to entorhinal cortex lesions in male rats. Molec. Brain Res. 10 (1991) 291-297.
23. O'Callaghan J. P., Brinton R. E. and McEwen B. S.: Glucocorticoid regulate the synthesis of glial fibrillary acidic protein in intact and adrenalectomized rats but do not affect its expression following brain injury. J. Neurochem. 57 (1991) 860-869.
24. O'Banion M. K., Young D. A. and Bohn M. C.: Corticosterone-responsive mRNAs in primary rat astrocytes. Molec. Brain Res. 22 (1994) 57-68.
25. Hall E. D.: Neuroprotective actions of glucocorticoid and nonglucocorticoid steroids in acute neuronal injury. Cell. Molec. Neurobiol. 13 (1993) 415-432.
26. Krieger C., Perry T. L., Hanse S., Mitsumoto H. and Honore T.: Excitatory amino acid receptor antagonist in murine motoneurone disease (the Wobbler mouse). Can. J. Neurol. Sci. 19 (1992) 462-465.
27. Rosner W. and Polimeni S. T.: An exchange assay for the cytoplasmic glucocorticoid receptor in the liver of the rat. Steroids 31 (1978) 427-438.
28. Orti E., Coirini H. and De Nicola A. F.: Properties and distribution of glucocorticoid-binding sites in cytosol of the spinal cord. Neuroendocrinology 40 (1985) 225-231.
29. Cressie N. A. C. and Keightley D. D.: The underlying structure of the direct linear plot with applications to the analysis of hormone receptor interactions. J. Steroid Biochem. 11 (1979) 1173-1180.
30. Russell D. and Snyder S. H.: Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo and various tumors. Proc. Natl. Acad. Sci. U.S.A. 60 (1968) 1420-1427.
31. Ferrini M., Gonzalez S., Antakly T. and De Nicola A. F.: Immunocytochemical localization of glucocorticoid receptors in the spinal cord: effects of adrenalectomy, glucocorticoid treatment and spinal cord transection. Cell. Molec. Neurobiol. 13 (1993) 387-398.
32. Rexed B.: A cytoarchitectonic atlas of the spinal core in the cat. J. Comp. Neurol. 100 (1954) 297-380.
33. Murphy B. E. P.: Clinical evaluation of urinary cortiso : determination by competitive protein-binding radioassay. J. Clin. Endocr. Metab. 28 (1968) 343-348.
34. De Nicola A. F., Moses D. F., Gonzalez S. and Orti E.: Adrenocorticoid action in the spinal cord: some unique molecular properties of glucocorticoid receptors. Cell. Molec. Neurobiol. 9 (1989) 179-192.
35. Duncan G. G. and Stumpf W. E.: Target neurons for (3H)corticosterone in the rat spinal cord. Brain Res. 307 (1984) 321-326.
36. Ovadia H., Vlodavsky I., Abramsky O. and Weidenfeld J.; Binding of hormonal steroids to isolated oligodendroglia and astroglia grown in vitro on a naturally produced extracellular matrix. Clin. Neuropharmacol. 7 (1984) 307-311.
37. Luttge W. A., Rupp M. E. and Davda M. N.: Aldesterone stimulated down-regulation of both type I and type II ,adrenocorticoid receptors in mouse brain is mediated via type I receptors. Endocrinology 125 (1989) 817-824.
38. Miller A. H., Spencer R. L., Husain A., Rhee R., McIwen B. S. and Stein M.: Differential expression of type I adrenalsteroid receptors in immune tissues is associated with tissue-specific regulation of type II receptors by aldosterone. Endocrinology 133 (1993) 2133-2140.
39. Magariños A. M., Somoza G. and De Nicola A. F.: Glucocorticoid negative feedback and glucocorticoid receptors after hippocampectomy in rats. Horm. Metab. Res. 19 (1987) 105-109.
40. Cintra A., Fuxe K., Agnati L. F., Persson L., Harfstrand A., Zoli M., Eneroth P. and Zini I.: Evidence for the existence of ornithine decarboxylase-immunoreactive neurons in the rat brain. Neurosci. Lett. 76 (1987) 269-274.
41. Junttila T., Hietanen-Peltola M., Rechard L., Persson L., Hokfelt T. and Pelto-Huikko M.: Ornithine decarboxylase-like immunoreactivity in rat spinal motoneurons and motoric nerves. Brain Res. 609 (1993) 149-153.
42. Muller M., Pajunen A. E. I., Jarvinen M., Poeggel G. and Bernstein H. G.: Immunohistochemical demonstration of 1-ornithine decarboxylase enzyme protein in different areas of the developing human brain. Dev. Neurosci. 15 (1993) 87-93.
43. Meyer J. S., Leveille P. J., de Vellis J., Gerlach J. L. and McEwen B. S.: Evidence for glucocorticoid target cells in the rat optic nerve. Hormone binding and glycerolphosphate dehydrogenase induction. J. Neurochem. 39 (1982) 423-434.
44. De Kloet E. R., Cousin M. A., Veldhuis H. D., Woornuis T. D. and Lando M.: Glucocorticoids modulate the response of ornithine decarboxylase to unilateral removal of the dorsal hippocampus. Brain Res. 275 (1983) 91-98.
45. Kanje M., Fransson I., Edstrom A. and Lowkovist B.: Ornithine decarboxylase activity in dorsal root ganglia o: Regenerating sciatic nerve. Brain Res. 381 (1986) 24-28.
46. Soifer A. I., Moretto A., Spencer P. S. and Dabri M. I.: Axotomy-induced ornithine decarboxylase activity in the mouse dorsal root ganglion is inhibited by the vinca alkaloids. Neurochem. Res. 13 (1988) 1169-1173.
47. Eng L. F.: Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes. J. Neuroimmunol. 8 (1985) 203-214.
48. Wilkin G. P., Marriot D. R. and Cholewinski A. J.: Astrocyte heterogeneity. TINS 13 (1990) 43-44.
49. Miller R. H., Zhang H. and Seang J. F.: Glial cell heterogeneity in the mammalian spinal cord. Persp. Dev. Neurobiol. 94 (1994) 225-231.
50. Blondet B., Hantaz-Ambroise D., Ait-Ikhef A., Cambier D., Murawsky M. and Rieger F.: Astrocytosis in Wobbler mouse spinal cord Involves a population of astrocytes which is glutamine synthetase negative. Neurosci. Lett, 183 (1995) 179-182.
51. Quarles, R. H., Morell, P. and McFarlin, D. E., Diseases involving myelin. In Basic Neurochemistry, 4th edn, eds G. Siegel, B. Agranoff, R. W. Albers and P. Molinoff. Raven Press, New York, 1989, pp. 697-713.
52. Finch C. E. and Morgan D. G.: RNA and protein metabolism in the aging brain. Annu, Rev. Neurosci. 13 (1990) 75-88.
53. Gage F. H., Olejniczak P. and Armstrong D. M.: Astrocytes are important for sprouting in the septo-hippocampal circuit. Exp. Neural. 102 (1988) 2-12.
54. Muller H. W., Matthiessen H. P., Schmalenbach C. and Schroeder W. O.: Glial support of CNS neuronal survival, neurite growth and regeneration. Rest. Nenrol. Neurosci. 2 (1991) 229-232.
55. Giulian D. and Corpuz M.: Microglial secretion products and their impact on the nervous system, in Advances in Neurology, Vol 59, ed. F. J. Seil. Raven Press, New York, (1993, pp. 315-320.
56. McKeon R. J., Schreiber R. C., Rudge J. S. and Silver J.: Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J. Neurosci. 11 (1991) 3398-3411.
57. Reier, P. J. and Houle, J. D., The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair. In Advances in Neurology: Functional Recovery in Neurological Disease, ed. S. G. Waxman, Raven Press, New York, 1988, pp. 87-138.
58. McMillian M. K., Thai L., Hong J.-S., O'Callaghan J. P. and Pennypacker K. R.: Brain injury in a dish: a model for reactive gliosis. TINS 17 (1994) 138-142.
59. Rozovsky, I., Laping, N. J., Hogan, T. H., Huang, C. J., Teter, B., Nichols, N. R. and Finch, C. E., Regulation of GFAP mRNA by glucocorticoids in vitro, Vol. 19. Society for Ncuroscience, 23rd Annual Meeting, Washington D.C., 1993, p. 43.
60. Murayama S., Inoue K., Kawakami H., Bouidin T. W. and Suzuki K.: A unique pattern of astrocytosis in the primarymotor area in amyotrophic lateral sclerosis. Acta Neuropatnol. (Bert.) 82 (1991) 456-461.
61. Kamo H., Haebara H. and Akiguchi I.: A distinctive distribution of reactive astroglia in the precentral cortex in amvotrophic lateral sclerosis. Acta Neuropathol. (Berl.) 74 (1987) 33-38.