Development of a non-radioactive, 384-well format assay to detect inhibitors of the mitogen-activated protein kinase kinase 4

Assay and Drug Development Technologies

Volumn 3, Issue 1, 2005, Pages 65-76

  Togame, H ^a,b   Fuchikami, K ^a,c   Sagara, A ^a,d   Inbe, H ^a,e   Ziegelbauer, Karl ^a,f  

^a BAYER YAKUHIN LTD   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

^c In Silico Sciences Inc   (Japan)

^d Ominedo Pharmaceut Industry Co Ltd   (Japan)

^e DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^f BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; EUROPIUM; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4 INHIBITOR; PROTEIN ANTIBODY; STAUROSPORINE; STREPTAVIDIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; ENZYME ASSAY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; ESCHERICHIA COLI; HUMAN; IC 50; IN VITRO STUDY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS;

BIOLOGICAL ASSAY; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMANS; MAP KINASE KINASE 4; PROTEIN KINASE INHIBITORS; RADIOIMMUNOASSAY; RECOMBINANT PROTEINS; ROBOTICS;

EID: 17344367525     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2005.3.65     Document Type: Article

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