Excitatory actions of NMDA receptor antagonists in rat entorhinal cortex and cultured entorhinal cortical neurons

Neuropsychopharmacology

Volumn 21, Issue 1, 1999, Pages 137-146

  Väisänen, Jussi ^a   Lindén, Anni Maija ^a   Lakso, Merja ^a   Wong, Garry ^a   Heinemann, Uwe ^b   Castrén, Eero ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Hippocampus; Ketamine; Limbic cortex; NMDA receptor antagonists; Phencyclidine; Posterior cingulate cortex; Schizophrenia

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; DESIPRAMINE; DIZOCILPINE; HALOPERIDOL; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PENTOBARBITAL; PHENCYCLIDINE; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENTORHINAL CORTEX; EXCITATION; HIPPOCAMPUS; IMMUNOREACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; LIMBIC CORTEX; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSYCHOSIS; RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; AUTORADIOGRAPHY; CELLS, CULTURED; DIZOCILPINE MALEATE; ENTORHINAL CORTEX; EXCITATORY AMINO ACID ANTAGONISTS; IN SITU HYBRIDIZATION; KETAMINE; MALE; NEURONS; PHENCYCLIDINE; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER;

EID: 17144458196     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(99)00006-8     Document Type: Article

References (33)

1. Acheson A., Conover J.C., Fandl J.P., DeChiara T.M., Russell M., Thadani A., Squinto S.P., Yancopoulos G.D., Lindsay R.M. A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature. 374:1995;450-453.
2. Amaral D.G., Witter M.P. Hippocampal formation. Paxinos G. The Rat Nervous System. 1995;443-493 Academic Press, Sydney.
3. Arnold S.E., Lee V.M., Gur R.E., Trojanowski J.Q. Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia. Proc Natl Acad Sci USA. 88:1991;10850-10854.
4. Bogerts B. Recent advances in the neuropathology of schizophrenia. Schizophrenia Bull. 19:1993;431-445.
5. Castrén E., Berzaghi M.P., Lindholm D., Thoenen H. Differential effects of MK-801 on the brain-derived neurotrophic factor mRNA levels in different regions of rat brain. Exp Neurol. 122:1993;244-252.
6. Corso T.D., Sesma M.A., Tenkova T.I., Der T.C., Wozniak D.F., Farber N.B., Olney J.W. Multifocal brain damage induced by phencyclidine is augmented by pilocarpine. Brain Res. 752:1997;1-14.
7. Dragunow M., Faull R.L.M. MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain. Neurosci Lett. 113:1990;144-150.
8. Falkai P., Bogerts B., Rozumek M. Limbic pathology in schizophrenia. The entorhinal region-a morphometric study Biol Psychiatry. 24:1988;515-521.
9. Farber N.B., Wozniak D.F., Price M.T., Labruyere J., Huss J., St. Peter H., Olney J.W. Age-specific neurotoxicity in the rat associated with NMDA receptor blockade. Potential relevance to schizophrenia? Biol Psychiatry. 38:1995;788-796.
10. Farber N.F., Price M.T., Labruyere J., Nemnich J., St. Peter H., Wozniak D.F., Olney J.W. Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity. Biol Psychiatry. 34:1993;119-121.
11. Ghosh A., Carnahan J., Greenberg M.E. Requirement for BDNF in activity-dependent survival of cortical neurons. Science. 263:1994;1618-1623.
12. Gloveli T., Iserhot C., Schmitz D., Castrén E., Behr J., Heinemann U. Systemic administration of the phencyclidine compound MK-801 affects stimulus-induced field potentials selectively in layer III of rat medial entorhinal cortex. Neurosci Lett. 221:1997;93-96.
13. Horvath Z.C., Czopf J., Buzsaki G. MK-801-induced neuronal damage in rats. Brain Res. 753:1997;181-195.
14. Hughes P., Dragunow M., Beilharz E., Lawlor P., Gluckman P. MK801 induces immediate-early gene proteins and BDNF mRNA in rat cerebrocortical neurones. NeuroReport. 4:1993;183-186.
15. Jakob H., Beckmann H. Circumscribed malformation and nerve cell alterations in the entorhinal cortex of schizophrenics. Pathogenetic and clinical aspects J Neural Transm Gen Sect. 98:1994;83-106.
16. Javitt D.C., Zukin S.R. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 148:1991;1301-1308.
17. Johnson K.M., Jones S.M. Neuropharmacology of phencyclidine. Basic mechanisms and therapeutic potential Annu Rev Pharmacol Toxicol. 30:1990;707-750.
18. Jones R.S.G. Entorhinal-hippocampal connections. A speculative view of their function Trends Neurosci. 16:1993;58-64.
19. Krystal J.H., Karper L.P., Seibyl J.P., Freeman G.K., Delaney R., Bremner J.D., Heninger G.R., Bowers M.B., Charney D.S. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, Perceptual, Cognitive, and Neuroendocrine Responses Arch Gen Psychiatry. 51:1994;199-214.
20. Lindholm D., Hengerer B., Castrén E. In vitro and in vivo methods for evaluating actions of cytokines on nerve growth factor production in central nervous system. DeSouza E. Neurobiology of Cytokines, Methods in Neurosciences, Vol. 17. 1993;37-60 Academic Press, San Diego.
21. Mattson M.P., Rychlik B., Cheng B. Degenerative and axon outgrowth-altering effects of phencyclidine in human fetal cerebral cortical cells. Neuropharmacology. 31:1992;279-291.
22. Morgan J.I., Curran T. Stimulus-transcription coupling in the nervous system. Involvement of the inducible proto-oncogenes fos and jun Annu Rev Neurosci. 14:1991;421-451.
23. Näkki R., Koistinaho J., Sharp F.R., Sagar S.M. Cerebellar toxicity of phencyclidine. J Neurosci. 15:1995;2097-2108.
24. Näkki R., Sharp F.R., Sagar S.M., Honkaniemi J. Effects of phencyclidine on immediate early gene expression in the brain. J Neurosci Res. 45:1996;13-27.
25. Olney J.W., Farber N.B. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry. 52:1995;998-1007. a.
26. Olney J.W., Farber N.B. NMDA antagonists as neurotherapeutic drugs, psychotogens, neurotoxins, and research tools for studying schizophrenia. Neuropsychopharmacology. 13:1995;335-345. b.
27. Olney J.W., Labruyere J., Price M.T. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science. 244:1989;1360-1362.
28. Olney J.W., Labruyere J., Wang G., Wozniak D.F., Price M.T., Sesma M.A. NMDA antagonist neurotoxicity. Mechanism and prevention Science. 254:1991;1515-1518.
29. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd ed:1986;Academic Press, Sydney.
30. Roberts G.W. Schizophrenia. The cellular biology of a functional psychosis Trends Neurosci. 13:1990;207-211.
31. Sharp F.R., Butman M., Koistinaho J., Aardalen K., Näkki R., Massa S.M., Swanson R.A., Sagar S.M. Phencyclidine induction of the hsp70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels. Neuroscience. 62:1994;1079-1092.
32. Sharp F.R., Jasper P., Hall J., Noble L., Sagar S.M. MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex. Ann Neurol. 30:1991;801-809.
33. Silbersweig D.A., Stern E., Frith C., Cahill C., Holmes A., Groontoonk S., Seaward J., McKenna P., Chua S.E., Schnorr L., Jones T., Frackowiak R.S.J. A functional neuroanatomy of hallucinations in schizophrenia. Nature. 378:1995;176-179.