Systemic administration of the phencyclidine compound MK-801 affects stimulus-induced field potentials selectively in layer III of rat medial entorhinal cortex

Neuroscience Letters

Volumn 221, Issue 2-3, 1997, Pages 93-96

  Gloveli, Tengis ^a,b   Iserhot, Claudia ^a,b   Schmitz, Dietmar ^a,b   Castrén, Eero ^a,b   Behr, Joachim ^a,b   Heinemann, Uwe ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

entorhinal cortex; field potentials; in vitro; MK 801; rat; systemic administration

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENTORHINAL CORTEX; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBICULUM;

ANIMALS; DIZOCILPINE MALEATE; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; ENTORHINAL CORTEX; EVOKED POTENTIALS; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MEMBRANE POTENTIALS; MICROINJECTIONS; RATS; RATS, WISTAR;

EID: 0343471497     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13307-3     Document Type: Article

References (18)

1. Benes, F.M., Vincent, S.L., Alsterberg, G., Bird, E.D. and SanGiovanni, J.P., Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics, J. Neurosci., 12 (1992) 924-929.
2. Brown, R., Colter, N., Corsellis, J.A., Crow, T.J., Frith, C.D., Jagoe, R., Johnstone, E.C. and Marsh, L., Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder, Arch. Gen. Psychiatry, 43 (1986) 36-42.
3. Corso, T., Neafsey, E.L. and Collins, M., Ethanol-induced degeneration of dentate gyrus, entorhinal cortex and other olfactory related areas in rat: effects of co-administration of MK-801. DNQX, or nimodipine, Soc. Neurosci. Abstr., 18 (1992) 540.
4. Dirnagl, U., Tanabe, J. and Pulsinelli, W., Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat, Brain Res., 527 (1990) 62-68.
5. Dreier, J.P. and Heinemann, U., Regional and time dependent variations of low magnesium induced epileptiform activity in rat temporal cortex, Exp. Brain Res., 87 (1991) 581-596.
6. Ellison, G., Competitive and non-competitive NMDA antagonists induce similar limbic degeneration, NeuroReport, 5 (1994) 2688-2692.
7. Falkai, P., Bogerts, B. and Rozumek, M., Limbic pathology in schizophrenia: the entorhinal region - a morphometric study, Biol. Psychiatry, 24 (1988) 515-521.
8. Hatfield, R.H., Gill, R. and Brazell, C., The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model, Eur. J. Pharmacol., 216 (1992) 1-7.
9. Jakob, H. and Beckmann, H., Circumscribed malformation and nerve cell alterations in the entorhinal cortex of schizophrenics. Pathogenetic and clinical aspects, , J. Neural Transm., 98 (1994) 83-106.
10. Lorente de Nó, R., Studies on the structure of the cerebral cortex, J. Psychol. Neurol., 45 (1933) 381-438.
11. Marshall, B.E. and Longnecker, D.E., General anesthetics. In A.G. Gilman, T.W. Rail, A.S. Nies and P. Taylor (Eds.), Goodman and Gilman's The Pharmacological Basis of Therapeutics, Vol. 8, Pergamon Press, New York, 1990, p. 307.
12. Olney, J.W. and Farber, N.B., Glutamate receptor dysfunction and schizophrenia, Arch. Gen. Psychiatry, 52 (1995) 998-1007.
13. Olney, J.W., Labruyere, J. and Price, M.T., Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs, Science, 244 (1989) 1360-1362.
14. Park, C.K., Nehls, D.G., Graham, D.I., Teasdale, G.M. and McCulloch, J., Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia, J. Cerebral Blood Flow Metab., 8 (1988) 757-762.
15. Roberts, G., Schizophrenia: a neuropathological perspective, Br. J. Psychiatry, 158 (1991) 8-17.
16. Snyder, S.H., Dopamine receptors, neuroleptics, and schizophrenia, Am. J. Psychiatry, 138 (1981) 460-464.
17. Willis, C.L., Brazell, C. and Foster, A.C., Plasma and CSF levels of dizocilpine (MK-801) required for neuroprotection in the quinolinate-injected rat striatum, Eur. J. Pharmacol., 196 (1991) 285-290.
18. Witter, M.P., Organization of the entorhinal-hippocampal system: a review of current anatomical data, Hippocampus, 3 (Suppl.)(1993) 33-44.