Synthesis, structure-activity relationships at the GABAA receptor in rat brain, and differential electrophysiological profile at the recombinant human GABAA receptor of a series of substituted 1,2-diphenylimidazoles

Journal of Medicinal Chemistry

Volumn 48, Issue 7, 2005, Pages 2638-2645

  Asproni, Battistina ^a   Talani, Giuseppe ^b   Busonero, Fabio ^b   Pau, Amedeo ^a   Sanna, Sebastiano ^a   Cerri, Riccardo ^a   Mascia, Maria Paola ^c   Sanna, Enrico ^b   Biggio, Giovanni ^b,c  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; CHLORIDE CHANNEL; ETHYL 2 (4 BROMOPHENYL) 1 (2,4 DICHLOROPHENYL) 1H 4 IMIDAZOLECARBOXYLATE; ETOMIDATE; IMIDAZOLE DERIVATIVE; PROPOFOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN TISSUE; CHEMICAL MODIFICATION; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; EVOKED RESPONSE; NERVE EXCITABILITY; NEUROTRANSMITTER RELEASE; NONHUMAN; STRUCTURE ANALYSIS; SYNTHESIS; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; FEMALE; HUMANS; IMIDAZOLES; MALE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; REFLEX; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 17144426063     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049120y     Document Type: Article

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