tPA receptors and the fibrinolytic response in multiple sclerosis lesions

American Journal of Pathology

Volumn 166, Issue 4, 2005, Pages 1143-1151

  Gverić, Djordje ^a   Herrera, Blanca M ^b   Cuzner, M Louise ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANNEXIN II TETRAMER; LIPOCORTIN 2; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MEMBRANE RECEPTOR; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN[LYSINE]; TISSUE PLASMINOGEN ACTIVATOR; TISSUE PLASMINOGEN ACTIVATOR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; CELL SURFACE; CONTROLLED STUDY; CORRELATION ANALYSIS; FIBRINOLYSIS; GRAY MATTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOCALIZATION; MACROPHAGE; MULTIPLE SCLEROSIS; NERVE CELL; NERVE FIBER DEGENERATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

EID: 17144406095     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)62334-6     Document Type: Article

References (54)

1. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CFM, Cuzner ML: Plasminogen activators in multiple sclerosis lesions-implications for the inflammatory response and axonal damage. Brain 2001, 124:1978-1988
2. Inoue A, Koh CS, Yamazaki M, Yanagisawa N, Ishihara Y, Kim BS: Fibrin deposition in the central nervous system correlates with the degree of Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Neuroimmunol 1997, 77:185-194
3. Akassoglou K, Kombrinck KW, Degen JL, Strickland S: Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury. J Cell Biol 2000, 149:1157-1166
4. Ellis V: Cellular receptors for plasminogen activators-recent advances. Trends Cardiovasc Med 1997, 7:227-234
5. Zhang JC, Sakthivel R, Kniss D, Graham CH, Strickland DK, McCrae KR: The low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor regulates cell surface plasminogen activator activity on human trophoblast cells. J Biol Chem 1998, 273: 32273-32280
6. Fitzpatrick SL, Kassam G, Choi KS, Kang HM, Fogg DK, Waisman DM: Regulation of plasmin activity by annexin II tetramer. Biochemistry 2000, 39:1021-1028
7. Lee AYY, Fredenburgh JC, Stewart RJ, Rischke JA, Weitz JI: Like fibrin, (DD)E, the major degradation product of cross-linked fibrin, protects plasmin from inhibition by alpha (2)-antiplasmin. Thromb Haemostasis 2001, 85:502-508
8. Hajjar KA, Krishnan S: Annexin II: a mediator of the plasmin/plasminogen activator system. Trends Cardiovasc Med 1999, 9:128-138
9. Reeves SA, Chavez-Kappel C, Davis R, Rosenblum M, Israel MA: Developmental regulation of annexin-II (lipocortin-2) in human brain and expression in high-grade glioma. Cancer Res 1992, 52:6871-6876
10. Nygaard ST, Haugland HK, Kristoffersen EK, Lundjohansen M, Laerum OD, Tysnes OB: Expression of annexin II in glioma cell lines and in brain tumor biopsies. J Neuro-Oncol 1998, 38:11-18
11. Nilius B, Gerke V, Prenen J, Szucs G, Heinke S, Weber K, Droogmans G: Annexin II modulates volume-activated chloride currents in vascular endothelial cells. J Biol Chem 1996, 271:30631-30636
12. Cesarman GM, Guevara CA, Hajjar KA: An endothelial cell receptor for plasminogen tissue plasminogen activator (t-PA). 2. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation. J Biol Chem 1994, 269:21198-21203
13. Kassam G, Le BH, Choi KS, Kang HM, Fitzpatrick SL, Louie P, Waisman DM: The p11 subunit of the annexin II tetramer plays a key role in the stimulation of t-PA-dependent plasminogen activation. Biochemistry 1998, 37:16958-16966
14. Choi KS, Fitzpatrick SL, Filipenko NR, Fogg DK, Kassam G, Magliocco AM, Waisman DM: Regulation of plasmin-dependent fibrin clot lysis by annexin II heterotetramer. J Biol Chem 2001, 276:25212-25221
15. Kwon M, Caplan JF, Filipenko NR, Choi KS, Fitzpatrick SL, Zhang LB, Waisman DM: Identification of annexin II heterotetramer as a plasmin reductase. J Biol Chem 2002, 277:10903-10911
16. Siever DA, Erickson HP: Extracellular annexin II. Int J Biochem Cell B 1997, 29:1219-1223
17. Ling Q, Jacovina AT, Deora A, Febbraio M, Simantov R, Silverstein RL, Hempstead B, Mark WH, Hajjar KA: Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest 2004, 113:38-48
18. Falcone DJ, Borth W, Khan KMF, Hajjar KA: Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II. Blood 2001, 97:777-784
19. Brownstein C, Deora AB, Jacovina AI, Weintraub R, Gertler M, Khan KMF, Falcone DJ, Hajjar KA: Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: enhanced expression by macrophages. Blood 2004, 103:317-324
20. Siao CJ, Tsirka SE: Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II. J Neurosci 2002, 22:3352-3358
21. Garbuglia M, Bianchi R, Verzini M, Giambanco I, Donate R: Annexin II(2)-p11(2) (calpactin-I) stimulates the assembly of GFAP in a calcium-dependent and pH-dependent manner. Biochem Biophys Res Commun 1995, 208:901-909
22. Moestrup SK: The alpha(2)-macroglobulin receptor and epithelial glycoprotein-330-2 giant receptors mediating endocytosis of multiple ligands. BBA-Rev Biomembranes 1994, 1197:197-213
23. Marita M, Bu GJ, Holtzman DM, Schwarte AL: The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development. J Neurochem 1997, 68:587-595
24. Makarova A, Mikhailenko I, Bugge TH, List K, Lawrence DA, Strickland DK: The low density lipoprotein receptor-related protein modulates protease activity in the brain by mediating the cellular internalization of both neuroserpin and neuroserpin-tissue-type plasminogen activator complexes. J Biol Chem 2003, 278: 50250-50258
25. Tooyama I, Kawamata T, Akiyama H, Kimura H, Moestrup SK, Gliemann J, Matsuo A, McGeer PL: Subcellular localization of the low density lipoprotein receptor-related protein (a2-macroglobulin receptor) in human brain. Brain Res 1995, 691:235-238
26. Marzolo MP, von Bernhardi R, Bu GJ, Inestrosa NC: Expression of alpha(2)-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells. J Neurosci Res 2000, 60:401-411
27. Grimsley PG, Quinn KA, Owensby DA: Soluble low-density lipoprotein receptor-related protein. Trends Cardiovasc Med 1998, 8:363-368
28. Hahn-Dantona E, Ruiz JF, Bornstein P, Strickland DK: The low density lipoprotein receptor-related protein modulates levels of matrix metalloproteinase 9 (MMP-9) by mediating its cellular catabolism. J Biol Chem 2001, 276:15498-15503
29. Bu GJ, Rennke S: Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. J Biol Chem 1996, 271:22218-22224
30. Cuzner ML, Opdenakker G: Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system. J Neuroimmunol 1999, 94:1-14
31. Gveric D, Herrera B, Petzold A, Lawrence DA, Cuzner ML: Impaired fibrinolysis in multiple sclerosis: a role for tissue plasminogen activator inhibitors. Brain 2003, 126:1590-1598
32. Li H, Newcombe J, Groome NP, Cuzner ML: Characterization and distribution of phagocytic macrophages in multiple sclerosis plaques. Neuropathol Appl Neurobiol 1993, 19:214-223
33. Gveric D, Cuzner ML, Newcombe J: Insulin-like growth factors and binding proteins in multiple sclerosis plaques. Neuropathol Appl Neurobiol 1999, 25:215-225
34. Hajjar KA, Nachman RL: Endothelial cell-mediated conversion of Glu-plasminogen to Lys-plasminogen-further evidence for assembly of the fibrinolytic system on the endothelial cell surface. J Clin Invest 1988, 82:1769-1778
35. Silverstein RL, Friedlander RJ, Nicholas RL, Nachman RL: Binding of Lys-plasminogen to monocytes/macrophages. J Clin Invest 1988, 82:1948-1955
36. Menell JS, Cesarman GM, Jacovina AT, McLaughlin MA, Lev EA, Hajjar KA: Annexin II and bleeding in acute promyelocytic leukemia. New Engl J Med 1999, 340:994-1004
37. Falcone DJ, Borth W, McCaffrey TA, Mathew J, McAdam K: Regulation of macrophage receptor-bound plasmin by autoproteolysis. J Biol Chem 1994, 269:32660-32666
38. Akenami FT, Koskiniemi M, Farkkila M, Vaheri A: Cerebrospinal fluid plasminogen, plasmin and protease inhibitors in multiple sclerosis. Fibrinolysis Proteol 1999, 13:99-103
39. Chandler WL, Alessi MC, Aillaud MF, Vague P, Juhan-Vague I: Formation, inhibition and clearance of plasmin in vivo. Haemostasis 2000, 30:204-218
40. Choi KS, Ghuman J, Kassam G, Kang HM, Fitzpatrick SL, Waisman DM: Annexin II tetramer inhibits plasmin-dependent fibrinolysis. Biochemistry 1998, 37:648-655
41. Simon DI, Xu H, Vaughan DE: Cathepsin D-like aspartyl protease activity mediates the degradation of tissue-type plasminogen-activator plasminogen activator inhibitor-1 complexes in human monocytes. BBA-Mol Cell Res 1995, 1268:143-151
42. Chung CY, Murphy-Ullrich JE, Erickson HP: Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II. Mol Biol Cell 1996, 7:883-892
43. Gutowski NJ, Newcombe J, Cuzner ML: Tenascin-R and C in multiple sclerosis lesions: relevance to extracellular matrix remodelling. Neuropathol Appl Neurobiol 1999, 25:207-214
44. Degryse B, Neels JG, Czekay RP, Aertgeerts K, Kamikubo Y, Loskutoff DJ: The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1. J Biol Chem 2004, 279:22595-22604
45. Czekay RP, Kuemmel TA, Orlando RA, Farquhar MG: Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity. Mol Biol Cell 2001, 12:1467-1479
46. Kwaan HC, Wang J, Weiss I: Expression of receptors for plasminogen activators on endothelial cell surface depends on their origin. J Thromb Haemost 2004, 2:306-312
47. Shatos MA, Orfeo T, Doherty JM, Penar PL, Collen D, Mann KG: Alpha-thrombin stimulates urokinase production and DNA-synthesis in cultured human cerebral microvascular endothelial cells. Arterioscler Thromb Vasc 1995, 15:903-911
48. Levin EG, Santell L, Osborn KG: The expression of endothelial tissue plasminogen activator in vivo: a function defined by vessel size and anatomic location. J Cell Sci 1997, 110:139-148
49. Nieuwenhuizen W: Fibrin-mediated plasminogen activation. Fibrinogen 2001, 936:237-246
50. Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DK, Lawrence DA: Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest 2003, 112:1533-1540
51. Strickland S: Tissue plasminogen activator in nervous system function and dysfunction. Thromb Haemost 2001, 86:138-143
52. Qiu ZH, Strickland DK, Hyman BT, Rebeck GW: Alpha 2-macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons. J Biol Chem 2002, 277:14458-14466
53. Pagan AM, Bu GJ, Sun YL, Daugherty A, Holtzman DM: Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J Biol Chem 1996, 271:30121-30125
54. Bu GJ, Sun YL, Schwartz AL, Holtzman DM: Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein. J Biol Chem 1998, 273: 13359-13365