New insights into the interactions of serum proteins with bis(maltolato)oxovanadium(IV): Transport and biotransformation of insulin-enhancing vanadium pharmaceuticals

Journal of the American Chemical Society

Volumn 127, Issue 14, 2005, Pages 5104-5115

  Liboiron, Barry D ^a,c   Thompson, Katherine H ^a   Hanson, Graeme R ^b   Lam, Edmond ^a,d   Aebischer, Nicolas ^a,e   Orvig, Chris ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e Vifor SA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION SPECTROSCOPY; BLOOD; DRUG PRODUCTS; INSULIN; ORGANOMETALLICS; PARAMAGNETIC RESONANCE; PHARMACOKINETICS; SOLUTIONS; VANADIUM COMPOUNDS;

ALBUMIN; HUMAN SERUM ALBUMIN (HSA); INSULIN-ENHANCING COMPOUNDS; SERUM PROTEINS;

PROTEINS;

1 METHYLIMIDAZOLE; ANTIDIABETIC AGENT; APOTRANSFERRIN; BIS(MALTOLATO)OXOVANADIUM; HUMAN SERUM ALBUMIN; INSULIN; MALTOL; PLASMA PROTEIN; UNCLASSIFIED DRUG; VANADIUM DERIVATIVE; VANADYL SULFATE;

ABSORPTION SPECTROSCOPY; ARTICLE; CHELATION; COMPLEX FORMATION; COMPUTER SIMULATION; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG TRANSFORMATION; DRUG TRANSPORT; ELECTRON SPIN RESONANCE; IN VITRO STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; ROOM TEMPERATURE; THERMODYNAMICS;

APOPROTEINS; BIOTRANSFORMATION; DRUG SYNERGISM; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; IMIDAZOLES; INSULIN; KINETICS; MOLECULAR WEIGHT; PYRONES; SERUM ALBUMIN; TRANSFERRIN; VANADATES; VANADIUM COMPOUNDS;

EID: 17144397996     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja043944n     Document Type: Article

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