Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus

Metabolism: Clinical and Experimental

Volumn 45, Issue 9, 1996, Pages 1130-1135

  Boden, Guenther ^a,b   Chen, Xinhua ^a   Ruiz, Jose ^a   Van Rossum, George D V ^a   Turco, Salvatore ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; VANADYL SULFATE;

ARTICLE; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL SYMPTOM; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HUMAN; HYPERINSULINEMIA; LIPID METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SINGLE BLIND PROCEDURE;

EID: 0029768691     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90013-X     Document Type: Article

References (43)

1. Simons TJB: Vanadate - A new tool for biologists. Nature 281:337-338, 1979
2. World Health Organization: Vanadium. Environmental Health Criteria 81. Geneva, Switzerland, World Health Organization, 1988
3. Macara IG: Vanadium - An element in search of a role. Trends Biochem Sci 5:92-94, 1980
4. Nechay BR: Mechanism of action of vanadium. Annu Rev Pharmacol Toxicol 24:501-524, 1984
5. Shechter Y, Karlish SJD: Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions. Nature 284:556-558, 1980
6. Dubyak GR, Kleinzeller A: The insulin-mimetic effects of vanadate in isolated rat adipocytes. J Biol Chem 255:5306-5312, 1980
7. Degani H, Gochin M, Karlish SJD, et al: Electron paramagnetic studies and insulin-like effects of vanadium in rat adipocytes. Biochemistry 20:5795-5799, 1981
8. Shechter Y, Ron A: Effect of depletion of bicarbonate or phosphate ions on insulin action in rat adipocytes. J Biol Chem 261:14945-14950, 1986
9. Heyliger CE, Tahiliani AG, McNeill JH: Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Science 227:1474-1476, 1985
10. Meyerovitch J, Farfel Z, Sack J, et al: Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Characterization and mode of action. J Biol Chem 262:6658-6662, 1987
11. Pederson RA, Ramanadham S, Buchan AMJ, et al: Long-term effects of vanadyl treatment on streptozocin-induced diabetes in rats. Diabetes 38:1390-1395, 1989
12. Cam MC, Pederson RA, Brownsey RW, et al: Long-term effectiveness of oral vanadyl sulphate in streptozotocin-diabetic rats. Diabetologia 36:218-224, 1993
13. Shechter Y: Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes. Diabetes 39:1-5, 1990
14. Meyerovitch J, Backer JM, Kahn CR: Hepatic phosphotyrosine phosphatase activity and its alteration in diabetic rats. J Clin Invest 84:976-983, 1989
15. Lyonnet B, Martz X, Martin E: L'emploi therapeutique des derives du vanadium. Presse Med 1:191-192, 1889
16. Goldfine AB, Simonson DC, Folli F, et al: Metabolic effects of sodium metavanadate in humans with insulin-dependent and non-insulin-dependent diabetes mellitus: In vivo and in vitro studies. J Clin Endocrinol Metab 80:3311-3320, 1995
17. Cohen N, Halberstam M, Shlimovich P, et al: Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 95:2501-2509, 1995
18. Ramanadham S, Mongold JJ, Brownsey RW, et al: Oral vanadyl sulfate in treatment of diabetes mellitus in rats. Am J Physiol 257:H904-H911, 1989
19. Shimoyama R, Ray TK, Savage CR Jr, et al: In vivo and in vitro effects of antiinsulin receptor antibodies. J Clin Endocrinol Metab 59:916-923, 1984
20. Molina JM, Baron AD, Edelman SV, et al: Use of a variable tracer infusion method to determine glucose turnover in humans. Am J Physiol 258:E16-E23, 1990
21. Steele R, Wall JS, DeBodo RC, et al: Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 187:15-24, 1956
22. Rossetti L, Giaccari A: Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal diabetic rats. J Clin Invest 85:1785-1792, 1990
23. Rossetti L, Lee Y-T, Ruiz J, et al: Quantitation of glycolysis and skeletal muscle glycogen synthesis in humans. Am J Physiol 265:E761-E769, 1993
24. Boden G, Chen X, Ruiz J, et al: Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446, 1994
25. Owen OE, Trapp VE, Reichard GA Jr, et al: Effects of therapy on the nature and quantity of fuels oxidized during diabetic ketoacidosis. Diabetes 29:365-372, 1980
26. Tappy L, Owen OE, Boden G: Effect of hyperinsulinemia on urea pool size and substrate oxidation rates. Diabetes 37:1212-1216, 1988
27. Boden G, Chen X, DeSantis RA, et al: Ethanol inhibits insulin action on lipolysis and on insulin release in elderly men. Am J Physiol 265:E197-E202, 1993
28. Rosenblatt JI, Wolfe RR: Calculation of substrate flux using stable isotopes. Am J Physiol 254:E526-E531, 1988
29. Soeldner JS, Slone D: Critical variables in the radioimmunoassay of serum insulin using the double antibody technic. Diabetes 14:771-779, 1965
30. Desbuquois B, Aurbach GD: Use of polyethylene glycol to separate free and antibody bound peptide hormones in radioimmunoassays. J Clin Endocrinol Metab 33:732-738, 1971
31. Marsh WH, Fingerhut B, Miller H: Automated and manual direct method for the determination of blood urea. Clin Chem 11:624-627, 1965
32. Hawk P: The Kjeldahl method, in Oser BL (ed): Practical Physiological Chemistry. Toronto, Ontario, Canada, Blakiston, 1965, pp 814-822
33. Lorch E, Gey K: Photometric "titration" of free fatty acids with the Technicon autoanalyzer. Anal Biochem 16:244-252, 1966
34. Dole VP, Meinertz H: Microdetermination of long-chain fatty acids in plasma and tissues. J Biol Chem 235:2595-2599, 1960
35. Mongold JJ, Cros GH, Vian L, et al: Toxicological aspects of vanadyl sulphate on diabetic rats: Effects on vanadium levels and pancreatic B-cell morphology. Pharmacol Toxicol 67:192-198, 1990
36. Dimond EG, Caravaca J, Benchimol A: Vanadium. Excretion, toxicity, and lipid effect in men. Am J Clin Nutr 12:49-53, 1963
37. Somerville J, Davies B: Effect of vanadium on serum cholesterol. Am Heart J 64:54-56, 1962
38. Malabu UH, Dryden S, McCarthy HD, et al: Effects of chronic vanadate administration in the STZ-induced diabetic rat. The antihyperglycemic action of vanadate is attributable entirely to its suppression of feeding. Diabetes 43:9-15, 1994
39. Brichard SM, Pottier AM, Henquin JC: Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats. Endocrinology 125:2510-2516, 1989
40. Schroeder HA, Balassa JJ, Tipton IH: Abnormal trace metals in man: Vanadium. J Chronic Dis 16:1047-1071, 1963
41. Nechay BR, Nanninga LB, Nechay PSE, et al: Role of vanadium in biology. Fed Proc 45:123-132, 1986
42. Lonnroth P, Eriksson JW, Posner BI, et al: Peroxovanadate but not vanadate exerts insulin-like effects in human adipocytes. Diabetologia 36:113-116, 1993
43. Boden G, Davis K, Murer E: Effects of sodium orthovanadate (Na Ova) on glucose uptake (GU) in fat cells from rats and humans. Can J Physiol Pharmacol 72:P16, 1994 (suppl 3, abstr)