Synthesis of piperidinyl and pyrrolidinyl butyrates for potential in vivo measurement of cerebral butyrylcholinesterase activity

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 44, Issue 1, 2001, Pages 31-41

  Kikuchi, Tatsuya ^a,c   Fukushi, Kiyoshi ^a   Ikota, Nobuo ^a   Ueda, Takao ^b   Nagatsuka, Shin Ichiro ^a,b   Arano, Yasushi ^c   Irie, Toshiaki ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Butyrylcholinesterase; Piperidinyl butyrates; Positron emission tomography; Pyrrolidinyl butyrates

Indexed keywords

BRAIN; HYDROLYSIS; NEURODEGENERATIVE DISEASES; POSITRON EMISSION TOMOGRAPHY; POSITRONS;

ACETYLCHOLINESTERASE; ALZHEIMERS DISEASE; BIOCHEMICAL CHANGES; BUTYRYLCHOLINESTERASE; HYDROLYSIS RATE; IN-VIVO; IN-VIVO MEASUREMENT; MEASUREMENTS OF; PIPERIDINYL BUTYRATE; PYRROLIDINYL BUTYRATE;

ESTERS;

ACETYLCHOLINESTERASE; CARBON 11; CARBON 14; CHOLINE ACETYLTRANSFERASE; CHOLINESTERASE; PIPERIDINE DERIVATIVE; PIPERIDINYL BUTYRATE; PYRROLIDINE BUTYRATE; PYRROLIDINE DERIVATIVE; TRACER; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; CHOLINERGIC SYSTEM; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; HYDROPHILICITY; ISOTOPE LABELING; LIPOPHILICITY; PARTITION COEFFICIENT; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE DIAGNOSIS;

EID: 0035170605     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.429     Document Type: Article

References (12)