Efficacy of vardenafil in men with erectile dysfunction: A flexible-dose community practice study

European Urology

Volumn 46, Issue 1, 2004, Pages 73-79

  Potempa, Axel Jürg ^a   Ulbrich, Ernst ^b   Bernard, Ingo ^b   Beneke, Manfred ^b  

^a Urologie Marienplatz   (Germany)

^b BAYER AG   (Germany)

Author keywords

Clinical trial; Drug therapy; Erectile dysfunction; Impotence; Oral therapy; PDE5; Phosphodiesterase inhibitor; Vardenafil

Indexed keywords

VARDENAFIL;

ADULT; AGED; ARTICLE; BALANITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; DYSPEPSIA; ERECTILE DYSFUNCTION; FLUSHING; FRANCE; GERMANY; HEADACHE; HEALTH CENTER; HUMAN; HYPERSENSITIVITY; MAJOR CLINICAL STUDY; MALE; NOSE OBSTRUCTION; OBSERVATION; OUTCOMES RESEARCH; PARESTHESIA; PENIS ERECTION; PHIMOSIS; PRIORITY JOURNAL; QUESTIONNAIRE; RHINOPHARYNGITIS; SELF REPORT; SEXUAL INTERCOURSE; TREATMENT OUTCOME;

ADULT; AGED; HUMANS; IMIDAZOLES; IMPOTENCE; MALE; MIDDLE AGED; PIPERAZINES; SULFONES; TRIAZINES;

EID: 2942585404     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2004.03.011     Document Type: Article

References (18)

1. National Institutes of Health. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993;270:83-90.
2. Bacon C.G., Mittleman M.A., Kawachi I., Giovannucci E., Glasser D.B., Rimm E.B. Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann. Intern. Med. 139:2003;161-168
3. Burnett A.L. Nitric oxide in the penis: physiology and pathology. J. Urol. 157:1997;320-324
4. Ignarro L.J., Bush P.A., Buga G.M., Wood K.S., Fukuto J.M., Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem. Biophys. Res. Commun. 170:1990;843-850
5. Lue T.F. Erectile dysfunction. N. Engl. J. Med. 342:2000;1802-1813
6. Ralph D., McNicholas T. UK management guidelines for erectile dysfunction. BMJ. 321:2000;499-503
7. Sáenz de Tejada I., Angulo J., Cuevas P., Fernandez A., Moncada I., Allona A., et al. The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int. J. Impot. Res. 13:2001;282-290
8. Bischoff E., Schneider K. A conscious-rabbit model to study vardenafil hydrochloride and other agents that influence penile erection. Int. J. Impot. Res. 13:2001;230-235
9. Porst H., Rosen R., Padma-Nathan H., Goldstein I., Giuliano F., Ulbrich E., et al. The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial. Int. J. Impot. Res. 13:2001;192-199
10. Porst H., Young J.M., Schmidt A.C., Buvat J. International Vardenafil Study Group Efficacy and tolerability of vardenafil for treatment of erectile dysfunction in patient subgroups. Urology. 62:2003;519-523
11. Brock G., Nehra A., Lipshultz L.I., Karlin G.S., Gleave M., Seger M., et al. Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy. J. Urol. 170:2003;1278-1283
12. Goldstein I., Young J.M., Fischer J., Bangerter K., Segerson T., Taylor T. Vardenafil, a new phosphodiesterase type 5 inhibitor in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study. Diabetes Care. 26:2003;777-783
13. Rosen R.C., Riley A., Wagner G., Osterloh I.H., Kirkpatrick J., Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 49:1997;822-830
14. Goldstein I., Lue T.F., Padma-Nathan H., Rosen R.C., Steers W.D., Wicker P.A. Oral sildenafil in the treatment of erectile dysfunction. N. Engl. J. Med. 338:1998;1397-1404
15. Nurnberg H.G., Hensley P.L., Gelenberg A.J., Fava M., Lauriello J., Paine S. Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial. JAMA. 289:2003;56-64
16. Rendell M.S., Rajfer J., Wicker P.A., Smith M.D. Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group. JAMA. 281:1999;421-426
17. Braatvedt G.D. Outcome of managing impotence in clinical practice. N Z Med. J. 112:1999;272-274
18. Hellstrom WJG, Gittelman M, Karlin G, Segerson T, Thibonnier M, Taylor T, Padma-Nathan H, on behalf of the Vardenafil Study Group. Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial. J Androl 2002;23:763-71.