Met72Thr polymorphism of pigment epithelium-derived factor gene and susceptibility to age-related macular degeneration

Medical Hypotheses

Volumn 64, Issue 6, 2005, Pages 1202-1204

  Yamagishi, S ^a   Nakamura, K ^a   Inoue, H ^a   Takeuchi, M ^b  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HOKURIKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; METHIONINE; PIGMENT EPITHELIUM DERIVED FACTOR; THREONINE;

ANGIOGENESIS; CELL CULTURE; CODON; DISEASE COURSE; DISEASE SEVERITY; DNA POLYMORPHISM; ENZYME POLYMORPHISM; EXON; GENETIC MARKER; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RETINA MACULA AGE RELATED DEGENERATION; SHORT SURVEY; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 17044428933     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.01.017     Document Type: Article

References (16)

1. C.Y. Hooper, and R.H. Guymer New treatments in age-related macular degeneration Clin Exp Ophthalmol 31 2003 376 391
2. J.R. Yates, and A.T. Moore Genetic susceptibility to age related macular degeneration J Med Genet 37 2000 83 87
3. Allikmets. Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR screening consortium. Am J Hum Genet 2000;67:487-91
4. G. Silvestri, P.B. Johnston, and A.E. Hughes Is genetic predisposition an important risk factor in age-related macular degeneration? Eye 8 1994 564 568
5. J. Tombran-Tink, C.G. Chader, and L.V. Johnson PEDF: pigment epithelium-derived factor with potent neuronal differentiative activity Exp Eye Res 53 1991 411 414
6. D.W. Dawson, O.V. Volpert, P. Gillis, S.E. Crawford, H.J. Xu, and W. Benedict Pigment epithelium-derived factor: a potent inhibitor of angiogenesis Science 285 1999 245 248
7. E.J. Duh, H.S. Yang, I. Suzuma, M. Miyagi, E. Youngman, and K. Mori Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth Invest Ophthalmol Vis Sci 43 2002 821 829
8. S. Yamagishi, Y. Inagaki, S. Amano, T. Okamoto, M. Takeuchi, and Z. Makita Pigment epithelium-derived factor protects cultured retinal pericytes from advanced glycation end product-induced injury through its antioxidative properties Biochem Biophys Res Commun 296 2002 877 882
9. S. Yamagishi, Y. Inagaki, S. Amano, T. Okamoto, and M. Takeuchi Up-regulation of vascular endothelial growth factor and down-regulation of pigment epithelium-derived factor messenger ribonucleic acid levels in leptin-exposed cultured retinal pericytes Int J Tissue React 24 2002 137 142
10. S. Yamagishi, S. Amano, Y. Inagaki, T. Okamoto, M. Takeuchi, and H. Inoue Pigment epithelium-derived factor inhibits leptin-induced angiogenesis by suppressing vascular endothelial growth factor gene expression through antioxidative properties Microvasc Res 65 2003 186 190
11. J. Spranger, M. Osterhoff, M. Reimann, M. Mohlig, M. Ristow, and M.K. Francis Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease Diabetes 50 2002 2641 2645
12. N.M. Holekamp, N. Bouck, and O. Volpert Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration Am J Ophthalmol 134 2002 220 227
13. R. Koenekoop, A.L. Pina, M. Loyer, J. Davidson, J. Robitaille, and I. Maumenee Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis Mol Vis 5 1999 10
14. S. Yamagishi, S. Amano, Y. Inagaki, T. Okamoto, Y. Koda, and M. Soejima Pigment epithelium-derived factor Met72Thr polymorphism in patients with diabetic microangiopathy Int J Clin Pharmacol Res 22 2002 67 71
15. E. Moreno, C. Tovar-Palacio, P. De Los Heros, B. Guzman, N.A. Bobadilla, and N. Vazquez A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity J Biol Chem 279 2004 16553 16560
16. B.A. Thomae, O.F. Rifki, M.A. Theobald, B.W. Eckloff, E.D. Wieben, and R.M. Weinshilboum Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism J Neurochem 87 2003 809 819