HFE mutations in the pathobiology of hemophilic arthropathy [1]

Blood

Volumn 105, Issue 8, 2005, Pages 3381-3382

  Cruz, Eugenia ^b   Porto, Graça ^b   Morais, Sara ^b   Campos, Manuel ^b   De Sousa, Marìa ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HFE PROTEIN; IRON;

ARTHROPATHY; DISEASE SEVERITY; FOLLOW UP; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HEMARTHROSIS; HEMOPHILIA; HEMOPHILIC ARTHROPATHY; HETEROZYGOSITY; HUMAN; IRON ABSORPTION; IRON BLOOD LEVEL; LETTER; PRIORITY JOURNAL; WILD TYPE;

EID: 17044402672     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-11-4342     Document Type: Letter

References (7)

1. Hakobyan N, Kazarian T, Jabbar AA, Jabbar KJ, Valentino LA. Pathobiology of hemophilic synovitis I: overexpression of mdm2 oncogene. Blood. 2004;104:2060-2064.
2. Abshire T. Are oncogenes responsible for hemophilic arthropathy? Blood. 2004;104:1911-1912.
3. Wen FQ, Jabbar AA, Chen YX, Kazarian T, Patel DA, Valentino LA. C-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide. Blood. 2002;100:912-916.
4. Nishiya K. Stimulation of human synovial cell DNA synthesis by iron. J Rheumatol. 1994;21:1802-1807.
5. Cruz E, Vieira J, Gonçalves R, et al. Involvement of the MHC region in the genetic regulation of circulating CD8+ T cell numbers in humans. Tissue Antigens. 2004;64:25-34.
6. de Sousa M, Dynesius-Trentham R, Mota-Garcia F, da Silva MT, Trentham DE. Activation of rat synovium by iron. Arthritis Rheumat. 1988;31:653-661.
7. Drakesmith H, Sweetland E, Schimanski L, et al. The hemochromatosis protein HFE inhibits iron export from macrophages. Proc Natl Acad Sci U S A. 2002;99:15602-15607.