Delayed neutralization of interferon-γ prevents lethality in primate Gram-negative bacteremic shock

Critical Care Medicine

Volumn 33, Issue 4, 2005, Pages 797-805

  Lainée, Pierre ^a   Efron, Philip ^b   Tschoeke, Sven K ^b   Elies, Laetitia ^a   De Winter, Hilde ^c   Lorré, Katrien ^c   Moldawer, Lyle L ^b  

^a CIT   (France)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c INNOGENETICS   (Belgium)

Author keywords

Cynomolgus; Inflammation; Multiple system organ failure; Sepsis; Severe sepsis; Systemic inflammatory response syndrome

Indexed keywords

GAMMA INTERFERON ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAUSE OF DEATH; CONTROLLED STUDY; CRYSTALLOID; CYTOKINE RELEASE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE SEPSIS; HEMODYNAMIC MONITORING; KIDNEY FAILURE; LETHALITY; MONKEY; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; RESUSCITATION; SEPTIC SHOCK; SERODIAGNOSIS; SURVIVAL RATE; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES, MONOCLONAL; BACTEREMIA; BIOLOGICAL MARKERS; CYTOKINES; DISEASE MODELS, ANIMAL; ESCHERICHIA COLI INFECTIONS; INFLAMMATION; INTERFERON TYPE II; MACACA FASCICULARIS; REFERENCE VALUES; SHOCK, SEPTIC; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME;

EID: 17044394020     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000159090.80228.57     Document Type: Article

References (20)

1. Martin GS, Mannino DM, Eaton S, et al: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-1554
2. Angus DC, Wax RS: Epidemiology of sepsis: an update. Crit Care Med 2001; 29:S109-S116
3. Bernard GR, Vincent JL, Laterre PF, et al: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709
4. Marshall JC: Such stuff as dreams are made on: Mediator-directed therapy in sepsis. Nat Rev Drug Discov 2003; 2:391-405
5. Baue AE: Multiple organ failure, multiple organ dysfunction syndrome, and systemic inflammatory response syndrome. Why no magic bullets? Arch Surg 1997; 132:703-707
6. Wang H, Yang H, Czura CJ, et al: HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med 2001; 164:1768-1773
7. O'Brien JM Jr, Abraham E: New approaches to the treatment of sepsis. Clin Chest Med 2003; 24:521-548
8. Jupin C, Anderson S, Damais C, et al: Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and gamma interferon. J Exp Med 1988; 167:752-761
9. Heinzel FP: The role of IFN-gamma in the pathology of experimental endotoxemia. J Immunol 1990; 145:2920-2924
10. Heremans H, Van Damme J, Dillen C, et al: Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice. J Exp Med 1990; 171:1853-1869
11. Bucklin SE, Russell SW, Morrison DC: Participation of IFN-gamma in the pathogenesis of LPS lethality. Prog Clin Biol Res 1994; 388:399-406
12. Hesse DG, Tracey KJ, Fong Y, et al: Cytokine appearance in human endotoxemia and primate bacteremia. Surg Gynecol Obstet 1988; 166:147-153
13. Armour KL, Clark MR, Hadley AG, et al: Recombinant human IgG molecules lacking Fcgamma receptor I binding and monocyte triggering activities. Eur J Immunol 1999; 29:2613-2624
14. May LT, Neta R, Moldawer LL, et al: Antibodies chaperone circulating IL-6. Paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo. J Immunol 1993; 151:3225-3236
15. Rosenberg JJ, Martin SW, Seely JE, et al: Development of a novel, nonimmunogenic, soluble human TNF receptor type I (sTNFR-I) construct in the baboon. J Appl Physiol 2001; 91:2213-2223
16. Tracey KJ, Fong Y, Hesse DG, et al: Anticachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 1987; 330:662-664
17. Van Zee KJ, Moldawer LL, Oldenburg HS, et al: Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-1g fusion protein, Ro 45-2081. J Immunol 1996; 156:2221-2230
18. Docke WD, Randow F, Syrbe U, et al: Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment. Nat Med 1997; 3:678-681
19. Kox WJ, Bone RC, Krausch D, et al: Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: Proof of principle. Arch Intern Med 1997; 157:389-393
20. Volk HD, Reinke P, Krausch D, et al: Monocyte deactivation - Rationale for a new therapeutic strategy in sepsis. Intensive Care Med 1996; 22(Suppl 4):S474-S481