Monooxygenation of an aromatic ring by F43W/H64D/V68I myoglobin mutant and hydrogen peroxide: Myoglobin mutants as a model for P450 hydroxylation chemistry

Journal of Biological Chemistry

Volumn 280, Issue 13, 2005, Pages 12858-12866

  Pfister, Thomas D ^a   Ohki, Takahiro ^b   Ueno, Takafumi ^b   Hara, Isao ^c,f   Adachi, Seiji ^d   Makino, Yumiko ^e   Ueyama, Norikazu ^d   Lu, Yi ^a   Watanabe, Yoshihito ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b NAGOYA UNIVERSITY   (Japan)

^c GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^f NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; BINDING ENERGY; CATALYSIS; ENZYMES; HYDROGEN PEROXIDE; MASS SPECTROMETRY; OXIDATION; POLYPEPTIDES;

AROMATIC CARBONS; INTERMEDIATES; MYOGLOBIN (MB); TRYPTOPHAN;

PROTEINS;

CHEMICAL COMPOUND; CHYMOTRYPSIN; CYTOCHROME P450; FERRYLMYOGLOBIN; HEME; HYDROGEN PEROXIDE; TRYPTOPHAN;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME ENGINEERING; HEME SYNTHESIS; HYDROXYLATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN ISOLATION; PROTEIN VARIANT; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS;

5-HYDROXYTRYPTOPHAN; ANIMALS; BINDING SITES; CATALASE; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHYMOTRYPSIN; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; HEME; HEMEPROTEINS; HYDROGEN PEROXIDE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; MYOGLOBIN; OXYGEN; PEPTIDES; PHOSPHATES; POTASSIUM COMPOUNDS; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY; TRYPTOPHAN; ULTRAVIOLET RAYS; WHALES;

EID: 16844381712     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410853200     Document Type: Article

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