Accelerated transformation and deactivation of erythromycin in superheated water. 1. Temperature effects, transformation rates, and the impacts of dissolved organic matter

Environmental Science and Technology

Volumn 39, Issue 7, 2005, Pages 2294-2300

  Butler, Michelle N ^a   Weber Jr , Walter J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ORGANIC COMPOUNDS; THERMAL EFFECTS;

ANTIBIOTIC WASTES; DISSOLVED ORGANIC MATTER; ERYTHROMYCIN; MICROBIAL RESISTANCE;

ANTIBIOTICS;

ANTIBIOTIC AGENT; DISSOLVED ORGANIC MATTER; ERYTHROMYCIN;

ANTIBIOTICS; WASTE DISPOSAL;

ARTICLE; BATCH REACTOR; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); DRUG TRANSFORMATION; ENERGY; EXTRACTION; FLOW RATE; HEAT TREATMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REACTION ANALYSIS; REACTOR; TEMPERATURE DEPENDENCE; WASTE MANAGEMENT;

ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ERYTHROMYCIN; HEAT; KINETICS; WATER POLLUTION, CHEMICAL;

EID: 16844379632     PISSN: 0013936X     EISSN: None     Source Type: Journal    
DOI: 10.1021/es049398f     Document Type: Article

References (25)

1. Koplin, D.; Furlong, E.; Meyer, M.; Thurman, E.; Zaugg, S.; Barber, L.; Buxton, H. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance. Environ. Sci. Technol. 2002, 36, 1202-1211.
2. Zuccato, E.; Calamari, D.; Natangelo, M.; Fanelli, R. Presence of therapeutic drugs in the environment. Lancet 2000, 35, 1789-1790.
3. Sabath, L.; Lorian, L.; Gerstein, D.; Loder, B.; Finland, M. Enhancing effect on alkalinization of the medium on the activity of erythromycin against Gram-negative bacteria. Appl. Microbiol. 1968, 16, 1288-1292.
4. Atkins, P.; Herbert, T. O.; Jones, N. B. Kinetic studies on decomposition of erythromycin A in aqueous acidic and neutral buffers. Int. J. Pharm. 1986, 30, 199-207.
5. Connors, K. Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists; Wiley: New York, 1986.
6. Cachet, Th.; den Mooter, G. V.; Hauchecorne, R.; Vinckier, C.; Hoogmartens, J. Decomposition kinetics of erythromycin A in acidic aqueous solutions. Int. J. Pharm. 1989, 55, 59-65.
7. Kibwage, I. O.; Busson, R.; Janssen, G.; Hoogmartens, J.; Vanderhaeghe, H. Translactonization in erythromycins. J. Org. Chem. 1987, 52, 990-996.
8. Vinckier, C.; Hauchecorne, R.; Cachet, Th.; den Mooter, V.; Hoogmartens, J. A new mechanism for the decomposition of erythromycin A in acidic aqueous solutions. Int. J. Pharm. 1989, 55, 67-76.
9. Katritzky, A. R.; Allin, S. M. Aquathermolysis: Reactions of organic compounds with superheated water. Acc. Chem. Res. 1996, 29, 399-406.
10. Siskin, M.; Katrisky, A. R. A review of the reactivity of organic compounds with oxygen-containing functionality in super-heated water. J. Anal. Appl. Phys. 2000, 54, 193-214.
11. Holliday, R. L.; Jong, B. Y. M.; Kolis, J. W. Organic synthesis in subcritical water oxidation of alkyl aromatics. J. Supercrit. Fluids 1998, 12, 255-260.
12. Jennings, J. M.; Bryson, T. A.; Gibson, J. M. Catalytic reduction in subcritical water. Green Chem. 2000, 87-88.
13. Miller, D. J.; Hawthorne, S. B. Solubility of liquid organics of environmental interest in subcritical (hot/liquid) water from 298K to 473K. J. Chem. Eng. Data 2000, 45, 78-81.
14. Shanableh, A. Generalized first-order kinetic model for biosolids decomposition and oxidation during hydrothermal treatment. Environ. Sci. Technol. 2005, 39, 355-362.
15. Shanableh, A.; Jomaa, S. Production and transformation of volatile fatty acids from sludge subjected to hydrothermal treatment. Water Sci. Technol. 2001, 44, 129-135.
16. Kubatova, A.; Herman, J.; Steckler, T. S.; De Veij, M.; Miller, D.; Klunder, E.; Wai, C. M.; Hawthorne, S. Subcritical (hot/liquid) water dechlorination of PCBs (Aroclor 1254) with metal additives and in waste paint. Environ. Sci. Technol. 2003, 37, 5757-5762.
17. Yang, Y.; Hawthorne, S. B.; Miller, D. J. Class-selective extraction of polar, moderately polar, and nonpolar organics from hydrocarbon wastes using subcritical water. Environ. Sci. Technol. 1997, 31, 430-437.
18. Field, J. A.; Reed, R. L. Subcritical (hot) water/ethanol extraction of nonylphenol polyethoxy carboxylates from industrial and municipal sludges. Environ. Sci. Technol. 1999, 33, 2782-2787.
19. Johnson, M. D.; Huang, W.; Dang, Z. D.; Weber, W. J., Jr. A distributed reactivity model for sorption by soils and sediments. 12. Effects of subcritical water extraction and alterations of soil organic matter on sorption equilibria. Environ. Sci. Technol. 1999, 33, 1657-1663.
20. Hawthorne, S. B.; Lagadec, A. J. M.; Kalderis, D.; Lilke, A. V.; Miller, D. J. Pilot scale destruction of TNT, RDX, and HMX on contaminated soils using subcritical water. Environ. Sci. Technol. 2000, 34, 3224-3228.
21. Lagadec, A. J. M.; Miller, D. J.; Lilke, A. V.; Hawthorne, S. B. Pilot-scale remediation of polycyclic aromatic hydrocarbon- and pesticide-contaminated soil. Environ. Sci. Technol. 2000, 34, 1542-1548.
22. Weber, W. J., Jr.; DiGiano, F. A. Process Dynamics in Environmental Systems; Wiley: New York, 1996.
23. Paesen, J.; Khan, K.; Roets, E.; Hoogmartens, J. Study of the stability of erythromycin in neutral and alkaline solutions by liquid chromatography on poly(styrene-divinylbenzene). Int. J. Pharm. 1994, 113, 215-222.
24. Volmer, D. A.; Hui, J. P. M. Study of erythromycin A decomposition products in aqueous solution by solid-phase micro-extraction/liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 1998, 12, 123-129.
25. Butler, M. N.; Weber, W. J., Jr. Accelerated transformation and deactivation of erythromycin in superheated waters. 2. Transformation reactions and bioassays. Environ. Sci. Technol. 2005, 39, 2301-2306.