O6-Alkylguanine-DNA alkyltransferase: Influence on susceptibility to the genetic effects of alkylating agents

Toxicology Letters

Volumn 102-103, Issue , 1998, Pages 53-57

  Kyrtopoulos, Soterios A ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

Author keywords

Cytostatic drugs; Methylating agents; N Nitroso compounds; O6 Methylguanine

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ALKYLATING AGENT; METHYLNITROSOUREA; DNA; DRUG DERIVATIVE; GUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE;

ANIMAL CELL; ANIMAL MODEL; CONFERENCE PAPER; DNA REPAIR; DRUG SENSITIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ARTICLE; DRUG EFFECT; HUMAN; METABOLISM; METHYLATION; PHYSIOLOGY;

ALKYLATING AGENTS; DNA; DNA REPAIR; GUANINE; HUMANS; METHYLATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE;

EID: 16744362253     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00282-3     Document Type: Conference Paper

References (23)

1. 6-methylguanine lesion. Mol. Cell Biol. 18, 1660-1669.
2. 6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea. Proc. Natl. Acad. Sci. U.S.A. 95, 1635-1640.
3. 6-Alkylguanine-DNA alkyltransferase. A target for the modulation of drug resistance. Hematol. Oncol. Clin. North Am. 9, 431-450.
4. 6-Alkylguanine-DNA alkyltransferase attenuates triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210 leukemia. Cancer Res. 55, 6231-6236.
5. Ishibashi, T., Nakabeppu, Y., Kawate, H., Sakumi, K., Hayakawa, H., Sekiguchi, M., 1994. Intracellular localization and function of DNA repair methyltransferase in human cells. Mutat. Res. 315, 199-212.
6. Jansen, J.G., Mohn, G.R., Vrieling, H., van Teijlingen, C.M., Lohman, P.H., van Zeeland, A.A., 1994. Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea. Cancer Res. 54, 2478-2485.
7. Kawate, H., Sakumi, K., Tsuzuki, T., et al., 1998. Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes. Proc. Natl. Acad. Sci. U.S.A. 95, 5116-5120.
8. Kyrtopoulos, S.A., Souliotis, V.L., Chhabra, S.K., Anderson, L.M., 1996. DNA damage studies related to the assessment of the role of N-nitroso compounds in human cancer. Eur. J. Cancer Prev. 5, 109-114.
9. 6-alkylguanine-DNA alkyltransferase in human peripheral leukocytes. Cancer Res. 54, 4046-4072.
10. 6-methylguanine-DNA methyltransferase are both required for its nuclear localization: the possible implications. EMBO J. 15, 4050-4060.
11. 6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas. Cancer Res. 54, 4648-4652.
12. - cell lines: differential potentiation by 3-acetamidobenzamide. Br. J. Cancer 57, 54-58.
13. Moritz, T., Mackay, W., Glassner, B.J., Williams, D.A., Samson, L., 1995. Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo. Cancer Res. 55, 2608-2614.
14. 6-Methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 90, 6468-6472.
15. 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res. 50, 6119-6129.
16. 6-alkylguanine-DNA alkyltransferase. Prog. Nucleic Acid. Res. Mol. Biol. 51, 167-223.
17. 6-methylguanine. Carcinogenesis 18, 2191-2196.
18. 6-methylguanine in humans and rodents treated with procarbazine. Carcinogenesis 15, 1675-1680.
19. 6-methylguanine in rat DNA after low-dose, chronic exposure to N-nitrosodimethylamine (NDMA). Implications for the mechanism of NDMA hepatocarcinogenesis. Carcinogenesis 16, 2381-2387.
20. 6-methylguanine in humans and rodents treated with dacarbazine. Carcinogenesis 17, 725-732.
21. Souliotis, V.L., van Delft, J.H.M., Steenwinkel, M.J., Baan, R.A., Kyrtopoulos, S.A., 1998. DNA adducts, mutant frequencies and mutation spectra in lambda lacZ transgenic mice treated with N-nitrosodimethylamine. Carcinogenesis 19, 731-739.
22. 6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea. Biochemistry 35, 1328-1334.
23. Zaidi, N.H., Allay, E., Ayi, T.C., et al., 1995. The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene. Carcinogenesis 16, 1047-1053.