Endothelial progenitor cells: Past, state of the art, and future

Journal of Cellular and Molecular Medicine

Volumn 8, Issue 4, 2004, Pages 488-497

  Iwami, Yo ^a   Masuda, Haruchika ^a   Asahara, Takayuki ^a,b  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b RIKEN   (Japan)

Author keywords

Angiogenesis; Cardiovascular disease; Cell therapy; Endothelial progenitor cell (EPC); Therapeutic neovascularization; Vasculogenesis

Indexed keywords

ANGIOGENESIS; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; GENE THERAPY; HUMAN; KINETICS; METHODOLOGY; PHENOTYPE; REVIEW; STEM CELL; STEM CELL TRANSPLANTATION; TIME; VASCULAR ENDOTHELIUM;

ANIMALS; ENDOTHELIUM, VASCULAR; GENE THERAPY; HUMANS; KINETICS; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PHYSIOLOGIC; PHENOTYPE; STEM CELL TRANSPLANTATION; STEM CELLS; TIME FACTORS;

EID: 16644401884     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2004.tb00473.x     Document Type: Review

References (41)

1. Asahara T., Murohara T., Sullivan A., Silver M., van der Zee R., Li T., Witzenbichler B., Schatteman G., Isner J.M., Isolation of putative progenitor endothelial cells for angiogenesis, Science, 275: 964-967, 1997
2. Shi Q., Rafii S., Wu M.H., Wijelath E.S., Yu C., Ishida A., Fujita Y., Kothari S., Mohle R., Sauvage L.R., Moore M.A., Storb R.F., Hammond W.P., Evidence for circulating bone marrow-derived endothelial cells, Blood, 92: 362-367, 1998
3. Asahara T., Masuda H., Takahashi T., Kalka C., Pastore C., Silver M., Kearne M., Magner M., Isner J.M., Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization, Circ Res, 85: 221-228, 1999
4. Gehling U.M., Ergun S., Schumacher U., Wagener C., Pantel K., Otte M., Schuch G., Schafhausen P., Mende T., Kilic N., Kluge K., Schafer B., Hossfeld D.K., Fiedler W., In vitro differentiation of endothelial cells from CD133-positive progenitor cells, Blood, 95: 3106-3112, 2000
5. Gunsilius E., Petzer A.L., Duba H.C., Kahler C.M., Gastl G., Circulating endothelial cells after transplantation, Lancet, 357: 1449-1450, 2001
6. Lin Y., Weisdorf D.J., Solovey A., Hebbel R.P., Origins of circulating endothelial cells and endothelial outgrowth from blood, J. Clin. Invest., 105: 71-77, 2000
7. Peichev M., Naiyer A.J., Pereira D., Zhu Z., Lane W.J., Williams M., Oz M.C., Hicklin D.J., Witte L., Moore M.A., Rafii S., Expression of VEGFR-2 and CD133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors, Blood, 95: 952-958, 2000
8. Nieda M., Nicol A., Denning Kendall P., Sweetenham J., Bradley B., Hows J., Endothelial cell precursors are normal components of human umbilical cord blood, Br J Haematol, 98: 775-777, 1997
9. Murohara T., Ikeda H., Duan J., Shintani S., Sasaki K., Eguchi H., Onitsuka I., Matsui K., Imaizumi T., Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization, J. Clin. Invest., 105: 1527-1536, 2000
10. Hatzopoulos A.K., Folkman J., Vasile E., Eiselen G.K., Rosenberg R.D., Isolation and characterization of endothelial progenitor cells from mouse embryos, Development, 125: 1457-1468, 1998
11. Springer M.L., Chen A.S., Kraft P.E., Bednarski M., Blau H.M., VEGF gene delivery to muscle: potential role for vasculogenesis in adults, Mol. Cell, 2: 549-58, 1998
12. Gill M., Dias S., Hattori K., Rivera M.L., Hicklin D., Witte L., Girardi L., Yurt R., Himel H., Rafii S., Vascular trauma induces rapid but transient mobilization of VEGFR2(+)CD133(+) endothelial precursor cells, Circ. Res., 88: 167-174, 2001
13. Asahara T., Takahashi T., Masuda H., Kalka C., Chen D., Iwaguro H., Inai Y., Silver M., Isner J.M., VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells, EMBO J., 18: 3964-3972, 1999
14. Iwaguro H., Yamaguchi J., Kalka C., Murasana S., Masuda H., Hayashi S., Silver M., Li T., Isner J.M., Asahara T., Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration, Circulation, 105: 732-738, 2002
15. Kalka C., Masuda H., Takahashi T., Kalka Moll W.M., Silver M., Kearney M., Li T., Isner J.M., Asahara T., Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization, Proc. Natl. Acad. Sci. USA, 97: 3422-3427, 2000
16. Schatteman G.C., Hanlon H.D., Jiao C., Dodds S.G., Christy B.A., Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice, J. Clin. Invest., 106: 571-578, 2000
17. Takahashi T., Kalka C., Masuda H., Chen D., Silver M., Kearney M., Magner M., Isner J.M., Asahara T., Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization, Nat. Med., 5: 434-438, 1999
18. Edelberg J.M., Tang L., Hattori K., Lyden D., Rafii S., Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function, Circ. Res., 90: E89-E93, 2002
19. Shintani S., Murohara T., Ikeda H., Ueno T., Honma T., Katoh A., Sasaki Ki., Shimada T., Oike Y., Imaizumi T., Mobilization of endothelial progenitor cells in patients with acute myocardial infarction., Circulation, 103: 2776-2779, 2001
20. Bhattacharya V., McSweeney P.A., Shi Q., Bruno B., Ishida A., Nash R., Storb R.F., Sauvage L.R., Hammond W.P., Wu M.H., Enhanced endothelialization and microvessel formation in polyester grafts seeded with CD34(+) bone marrow cells, Blood, 95: 581-585, 2000
21. Kaushal S., Amiel G.E., Guleserian K.J., Shapira O.M., Perry T., Sutherland F.W., Rabkin E., Moran A.M., Schoen F.J., Atala A., Soker S., Bischoff J., Mayer J.E. Jr., Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo, Nat. Med., 7: 1035-1040, 2001
22. Crosby J.R., Kaminski W.E., Schatteman G., Martin P.J., Raines E.W., Seifert R.A., Bowen Pope D.F., Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation, Circ. Res., 87: 728-730, 2000
23. Murayama T., Tepper O.M., Silver M., Ma H., Losordo D.W., Isner J.M., Asahara T., Kalka C., Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivo, Exp. Hematol., 30: 967-972, 2002
24. Reyes M., Dudek A., Jahagirdar B., Koodie L., Marker P.H., Verfaillie C.M., Origin of endothelial progenitors in human postnatal bone marrow, J. Clin. Invest., 109: 337-346, 2002
25. Tamaki T., Akatsuka A., Ando K., Nakamura Y., Matsuzawa H., Hotta T., Roy R.R., Edgerton V.R., Identification of myogenic-endothelial progenitor cells in the interstitial spaces of skeletal muscle, J. Cell. Biol., 157: 571-577, 2002
26. Vasa M., Fichtlscherer S., Aicher A., Adler K., Urbich C., Martin H., Zeiher A.M., Dimmeler S., Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease, Circ. Res., 89: E1-E7, 2001
27. Tepper O.M., Galiano R.D., Capla J.M., Kalka C., Gagne P.J., Jacobowitz G.R., Levine J.P., Gurtner G.C., Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures, Circulation, 106: 2781-6, 2002
28. Valgimigli M., Rigolin G.M., Fucili A., Della Porta M., Soukhomovskaia O., Malagutti P., Bugli A.M., Bragotti L.Z., Francolini G., Mauro E., Castoldi G., Ferrari R., CD34+ and Endothelial Progenitor Cells in Patients With Various Degrees of Congestive Heart Failure, Circulation, 110: 1209-1212, 2004
29. Kalka C., Masuda H., Takahashi T., Gordon R., Tepper O., Gravereaux E., Pieczek A., Iwaguro H., Hayashi S.I., Isner J.M., Asahara T., Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects, Circ. Res., 86: 1198-1202, 2000
30. Hattori K., Dias S., Heissig B., Hackett N.R., Lyden D., Tateno M., Hicklin D.J., Zhu Z., Witte L., Crystal R.G., Moore M.A., Rafii S., Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells, J. Exp. Med., 193: 1005-1014, 2001
31. Yamaguchi J., Kusano K.F., Masuo O., Kawamoto A., Silver M., Murasawa S., Bosch Marce M., Masuda H., Losordo D.W., Isner J.M., Asahara T., Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization, Circulation, 107: 1322-1328, 2003
32. Heeschen C., Aicher A., Lehmann R., Fichtlscherer S., Vasa M., Urbich C., Mildner Rihm C., Martin H., Zeiher A.M., Dimmeler S., Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization, Blood, 102: 1340-1346, 2003
33. Iwakura A., Luedemann C., Shastry S., Hanley A., Kearney M., Aikawa R., Isner J.M., Asahara T., Losordo D.W., Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury, Circulation, 108: 3115-3121, 2003
34. Strehlow K., Werner N., Berweiler J., Link A., Dirnagl U., Priller J., Laufs K., Ghaeni L., Milosevic M., Bohm M., Nickenig G., Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation, Circulation, 107: 3059-3065, 2003
35. Kureishi Y., Luo Z., Shiojima I., Bialik A., Fulton D., Lefer D.J., Sessa W.C., Walsh K., The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals, Nat. Med., 6: 1004-1010, 2000
36. Llevadot J., Murasawa S., Kureishi Y., Uchida S., Masuda H., Kawamoto A., Walsh K., Isner J.M., Asahara T., HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells, J. Clin. Invest., 108: 399-405, 2001
37. Dimmeler S., Aicher A., Vasa M., Mildner Rihm C., Adler K., Tiemann M., Rutten H., Fichtlscherer S., Martin H., Zeiher AM., HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway, J. Clin. Invest., 108: 391-397, 2001
38. Lyden D., Hattori K., Dias S., Costa C., Blaikie P., Butros L., Chadburn A., Heissig B., Marks W., Witte L., Wu Y., Hicklin D., Zhu Z., Hackett N.R., Crystal R.G., Moore M.A., Hajjar K.A., Manova K., Benezra R., Rafii S., Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth, Nat. Med., 7: 1194-1201, 2001
39. Kocher A.A., Schuster M.D., Szabolcs M.J., Takuma S., Burkhoff D., Wang J., Homma S., Edwards N.M., Itescu S., Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function, Nat. Med., 7: 430-436, 2001
40. Taguchi A., Soma T., Tanaka H., Kanda T., Nishimura H., Yoshikawa H., Tsukamoto Y., Iso H., Fujimori Y., Stern D.M., Naritomi H., Matsuyama T., Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model, J. Clin. Invest., 114: 330-338, 2004
41. Nagaya N., Kangawa K., Kanda M., Uematsu M., Horio T., Fukuyama N., Hino J., Harada Shiba M., Okumura H., Tabata Y., Mochizuki N., Chiba Y., Nishioka K., Miyatake K., Asahara T., Hara H., Mori H., Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells, Circulation, 108: 889-895, 2003