메뉴 건너뛰기




Volumn 5, Issue 5, 2004, Pages 359-367

Preview of new drugs for overactive bladder and incontinence: Darifenacin, solifenacin, trospium, and duloxetine

Author keywords

Detrusor Overactivity; Duloxetine; Overactive Bladder; Oxybutynin; Stress Urinary Incontinence

Indexed keywords

BENZOFURAN DERIVATIVE; DARIFENACIN; DULOXETINE; MUSCARINIC RECEPTOR BLOCKING AGENT; NORTROPANE DERIVATIVE; PYRROLIDINE DERIVATIVE; QUINUCLIDIN 3' YL 1 PHENYL 1,2,3,4 TETRAHYDROISOQUINOLINE 2 CARBOXYLATE MONOSUCCINATE; QUINUCLIDIN-3'-YL-1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE-2-CARBOXYLATE MONOSUCCINATE; QUINUCLIDINE DERIVATIVE; SEROTONIN UPTAKE INHIBITOR; TETRAHYDROISOQUINOLINE DERIVATIVE; THIOPHENE DERIVATIVE; TROSPIUM CHLORIDE;

EID: 16644394660     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-004-0083-x     Document Type: Article
Times cited : (26)

References (64)
  • 1
    • 0344091762 scopus 로고    scopus 로고
    • Incidence and prevalence of overactive bladder
    • PID: 12425863
    • Rovner ES, Wein AJ: Incidence and prevalence of overactive bladder. Curr Urol Rep 2002, 3:434–438. DOI: 10.1007/s11934-002-0093-5
    • (2002) Curr Urol Rep , vol.3 , pp. 434-438
    • Rovner, E.S.1    Wein, A.J.2
  • 2
    • 24144433760 scopus 로고    scopus 로고
    • The definition, prevalence, and risk factors for stress urinary incontinence
    • PID: 16985863
    • Luber KM: The definition, prevalence, and risk factors for stress urinary incontinence. Rev Urol 2004, 6(suppl 3):S3-S9.
    • (2004) Rev Urol , vol.6 , pp. S3-S9
    • Luber, K.M.1
  • 3
    • 0036186813 scopus 로고    scopus 로고
    • The standardization of terminology of lower urinary tract function: report from the Standardization Sub-committee of the International Continence Society
    • PID: 11857671
    • Abrams P, Cardozo L, Fall M, et al.: The standardization of terminology of lower urinary tract function: report from the Standardization Sub-committee of the International Continence Society. Neurourol Urodyn 2002, 21:167–178. DOI: 10.1002/nau.10052
    • (2002) Neurourol Urodyn , vol.21 , pp. 167-178
    • Abrams, P.1    Cardozo, L.2    Fall, M.3
  • 4
    • 0034185336 scopus 로고    scopus 로고
    • Discussion: functional role of M1,M2, and M3 muscarinic receptors in overactive bladder
    • PID: 10767451, COI: 1:STN:280:DC%2BD3c3jt1SmtQ%3D%3D
    • Igawa Y: Discussion: functional role of M1,M2, and M3 muscarinic receptors in overactive bladder. Urology 2000, 55(suppl_5A):47–49. DOI: 10.1016/S0090-4295(99)00493-8
    • (2000) Urology , vol.55 , pp. 47-49
    • Igawa, Y.1
  • 6
    • 0344394920 scopus 로고    scopus 로고
    • Pharmacological effects of darifenacin on human isolated urinary bladder
    • PID: 14624061, COI: 1:CAS:528:DC%2BD3sXptVWkur4%3D
    • Miyamae K, Masaki Y, Murakami S, et al.: Pharmacological effects of darifenacin on human isolated urinary bladder. Pharmacology 2003, 69:205–211 DOI: 10.1159/000073665
    • (2003) Pharmacology , vol.69 , pp. 205-211
    • Miyamae, K.1    Masaki, Y.2    Murakami, S.3
  • 7
    • 0036868034 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes and management of the overactive bladder
    • PID: 12493364
    • Chapple CR, Yamanishi T, Chess-Williams R: Muscarinic receptor subtypes and management of the overactive bladder. Urology 2002, 60:82–88. DOI: 10.1016/S0090-4295(02)01803-4
    • (2002) Urology , vol.60 , pp. 82-88
    • Chapple, C.R.1    Yamanishi, T.2    Chess-Williams, R.3
  • 8
    • 14944360517 scopus 로고    scopus 로고
    • Muscarinic receptor function in the idiopathic overactive bladder
    • Stevens L, Chess-Williams R, Chapple CR: Muscarinic receptor function in the idiopathic overactive bladder. J Urol 2004, 171(suppl 4):527a.
    • (2004) J Urol , vol.171 , pp. 527a
    • Stevens, L.1    Chess-Williams, R.2    Chapple, C.R.3
  • 9
    • 0035957577 scopus 로고    scopus 로고
    • Muscarinic receptors and gastrointestinal tract smooth muscle function
    • PID: 11392628, COI: 1:CAS:528:DC%2BD3MXjs1Wks7s%3D
    • Eglen RM: Muscarinic receptors and gastrointestinal tract smooth muscle function. Life Sci 2001, 68:2573–2578. DOI: 10.1016/S0024-3205(01)01054-2
    • (2001) Life Sci , vol.68 , pp. 2573-2578
    • Eglen, R.M.1
  • 10
    • 0028220922 scopus 로고
    • Muscarinic cholinergic receptor subtypes in rat sublingual glands
    • PID: 8141247, COI: 1:CAS:528:DyaK2cXitV2hur0%3D
    • Watson GE, Culp DJ: Muscarinic cholinergic receptor subtypes in rat sublingual glands. Am J Physiol 1994, 266:C335-C342.
    • (1994) Am J Physiol , vol.266 , pp. C335-C342
    • Watson, G.E.1    Culp, D.J.2
  • 11
    • 0002420012 scopus 로고
    • Darifenacin: a novel bladder-selective agent for the treatment of urge incontinence
    • Newgreen DT, Anderson DW, Carter AJ, et al.: Darifenacin: a novel bladder-selective agent for the treatment of urge incontinence. Neurourol Urodyn 1995, 14:555–557.
    • (1995) Neurourol Urodyn , vol.14 , pp. 555-557
    • Newgreen, D.T.1    Anderson, D.W.2    Carter, A.J.3
  • 12
    • 0033553589 scopus 로고    scopus 로고
    • Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland
    • PID: 10374898, COI: 1:CAS:528:DyaK1MXjtlGisbs%3D
    • Moriya H, Takagi Y, Nakanishi T, et al.: Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci 1999, 64:2351–2358. DOI: 10.1016/S0024-3205(99)00188-5
    • (1999) Life Sci , vol.64 , pp. 2351-2358
    • Moriya, H.1    Takagi, Y.2    Nakanishi, T.3
  • 13
    • 0030610603 scopus 로고    scopus 로고
    • Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo
    • Hedge SS, Choppin A, Bonhaus D, et al.: Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol 1997, 120:1409–1418. DOI: 10.1038/sj.bjp.0701048
    • (1997) Br J Pharmacol , vol.120 , pp. 1409-1418
    • Hedge, S.S.1    Choppin, A.2    Bonhaus, D.3
  • 14
    • 1542441705 scopus 로고    scopus 로고
    • Muscarinic receptors: what we know
    • PID: 14622493
    • Scarpero HM, Dmochowski RR: Muscarinic receptors: what we know. Curr Urol Rep 2003, 4:421–428. DOI: 10.1007/s11934-003-0021-3
    • (2003) Curr Urol Rep , vol.4 , pp. 421-428
    • Scarpero, H.M.1    Dmochowski, R.R.2
  • 15
    • 0002825399 scopus 로고    scopus 로고
    • The M2 muscarinic receptor subtype mediates cholinergic bladder contractions in patients with neurogenic bladder dysfunction
    • Braverman AS, Ruggieri MR, Pontari MA: The M2 muscarinic receptor subtype mediates cholinergic bladder contractions in patients with neurogenic bladder dysfunction. J Urol 2001, 165:36.
    • (2001) J Urol , vol.165 , pp. 36
    • Braverman, A.S.1    Ruggieri, M.R.2    Pontari, M.A.3
  • 16
    • 0032692814 scopus 로고    scopus 로고
    • Alterations in urinary bladder M2- muscarinic receptor protein and mRNA in 2-week streptozotocin-induced diabetic rats
    • Tong YC, Chin WT, Cheng JT: Alterations in urinary bladder M2- muscarinic receptor protein and mRNA in 2-week streptozotocin-induced diabetic rats. Neurosci Lett 1997, 277:173–176. DOI: 10.1016/S0304-3940(99)00871-X
    • (1997) Neurosci Lett , vol.277 , pp. 173-176
    • Tong, Y.C.1    Chin, W.T.2    Cheng, J.T.3
  • 17
    • 1942455224 scopus 로고    scopus 로고
    • The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction
    • PID: 14751843, COI: 1:CAS:528:DC%2BD2cXkt1enurc%3D
    • Pontari MA, Braverman AS, Ruggieri MR: The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction. Am J Physiol Regul Integr Comp Physiol 2004, 286:R874-R880.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286 , pp. R874-R880
    • Pontari, M.A.1    Braverman, A.S.2    Ruggieri, M.R.3
  • 18
    • 0642367799 scopus 로고    scopus 로고
    • Update on overactive bladder: pharmacologic approaches on the horizon
    • Rovner ES, Wein AJ: Update on overactive bladder: pharmacologic approaches on the horizon. Curr Urol Rep 2002, 4:385–390. DOI: 10.1007/s11934-003-0013-3
    • (2002) Curr Urol Rep , vol.4 , pp. 385-390
    • Rovner, E.S.1    Wein, A.J.2
  • 19
    • 1242306671 scopus 로고    scopus 로고
    • Assessment of the relative in vivo potency of the hydroxylated metabolite of darifenacin in its ability to decrease salivary flow using pooled population pharmacokinetic-pharmacodynamic data
    • PID: 14748816, COI: 1:CAS:528:DC%2BD2cXhvFehs7o%3D
    • Kerbusch T, Milligan PA, Karlsson MO: Assessment of the relative in vivo potency of the hydroxylated metabolite of darifenacin in its ability to decrease salivary flow using pooled population pharmacokinetic-pharmacodynamic data. Br J Clin Pharmacol 2004, 57:170–180. DOI: 10.1046/j.1365-2125.2003.01988.x
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 170-180
    • Kerbusch, T.1    Milligan, P.A.2    Karlsson, M.O.3
  • 20
    • 0000631335 scopus 로고    scopus 로고
    • The effects of single-dose darafenacin on cystometric parameters and salivary flow in patients with urge incontinence secondary to detrusor instability
    • Rosario DJ, Cutinha PE, Chapple CR: The effects of single-dose darafenacin on cystometric parameters and salivary flow in patients with urge incontinence secondary to detrusor instability. Eur Urol 1996, 30:240.
    • (1996) Eur Urol , vol.30 , pp. 240
    • Rosario, D.J.1    Cutinha, P.E.2    Chapple, C.R.3
  • 21
    • 0032907382 scopus 로고    scopus 로고
    • Pharmacodynamics of anticholinergic agents measured by ambulatory urodynamic monitoring: a study of methodology
    • PID: 10338443, COI: 1:CAS:528:DyaK1MXjtF2ku78%3D
    • Rosario DJ, Smith DJ, Radley SC, et al.: Pharmacodynamics of anticholinergic agents measured by ambulatory urodynamic monitoring: a study of methodology. Neurourol Urodyn 1999, 18:223–233. DOI: 10.1002/(SICI)1520-6777(1999)18:3<223::AID-NAU9>3.0.CO;2-6
    • (1999) Neurourol Urodyn , vol.18 , pp. 223-233
    • Rosario, D.J.1    Smith, D.J.2    Radley, S.C.3
  • 23
    • 1342331401 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo- and tolterodine-controlled trial of the once-daily anti-muscarinic agent solifenacin in patients with symptomatic overactive bladder
    • PID: 14764127, COI: 1:CAS:528:DC%2BD2cXis1ShsLo%3D, The first phase-3 study of an antimuscarinic agent to evaluate urgency as a primary efficacy variable patients with OAB. Patients who received solifenacin experienced statistically significant reductions daily urgency episodes relative to placebo
    • Chapple CR, Rechberger T, Al-Shukri S, et al.: Randomized, double-blind, placebo- and tolterodine-controlled trial of the once-daily anti-muscarinic agent solifenacin in patients with symptomatic overactive bladder. BJU Int 2004, 93:303–310. The first phase-3 study of an antimuscarinic agent to evaluate urgency as a primary efficacy variable in patients with OAB. Patients who received solifenacin experienced statistically significant reductions in daily urgency episodes relative to placebo. DOI: 10.1111/j.1464-410X.2004.04606.x
    • (2004) BJU Int , vol.93 , pp. 303-310
    • Chapple, C.R.1    Rechberger, T.2    Al-Shukri, S.3
  • 24
    • 2942695218 scopus 로고    scopus 로고
    • Darafenacin, an M3 selective receptor antagonist, reduces the frequency of nocturnal awakening, an important symptom of overactive bladder [Abstract 491]
    • Khullar V: Darafenacin, an M3 selective receptor antagonist, reduces the frequency of nocturnal awakening, an important symptom of overactive bladder [Abstract 491]. J Urol 2004, 171(suppl):131.
    • (2004) J Urol , vol.171 , pp. 131
    • Khullar, V.1
  • 25
    • 1642276168 scopus 로고    scopus 로고
    • Darafenacin, an M3 selective receptor antagonist, is an effective and well-tolerated once-daily treatment for overactive bladder
    • PID: 15041104, COI: 1:CAS:528:DC%2BD2cXjtlKitrk%3D
    • Haab F, Stewart L, Dwyer P: Darafenacin, an M3 selective receptor antagonist, is an effective and well-tolerated once-daily treatment for overactive bladder. Eur Urol 2004, 45:420–429. DOI: 10.1016/j.eururo.2004.01.008
    • (2004) Eur Urol , vol.45 , pp. 420-429
    • Haab, F.1    Stewart, L.2    Dwyer, P.3
  • 26
    • 0035992628 scopus 로고    scopus 로고
    • M3 receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland
    • PID: 12122494, COI: 1:CAS:528:DC%2BD38Xlt1Ggu7g%3D
    • Ikeda K, Kobyashi S, Miyata K, et al.: M3 receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch Pharmacol 2002, 366:97–103. DOI: 10.1007/s00210-002-0554-x
    • (2002) Naunyn Schmiedebergs Arch Pharmacol , vol.366 , pp. 97-103
    • Ikeda, K.1    Kobyashi, S.2    Miyata, K.3
  • 27
    • 0345059050 scopus 로고    scopus 로고
    • Comparison of in vitro selectivity profiles of solifenacin succinate (YM905) and current antimuscarinic drugs in bladder and salivary glands: a Ca2+ mobilization study in monkey cells
    • PID: 14659973, COI: 1:CAS:528:DC%2BD3sXps1Gqs7w%3D
    • Kobayashi S, Ikeda K, Miyata K: Comparison of in vitro selectivity profiles of solifenacin succinate (YM905) and current antimuscarinic drugs in bladder and salivary glands: a Ca2+ mobilization study in monkey cells. Life Sci 2004, 74:843–853. DOI: 10.1016/j.lfs.2003.07.019
    • (2004) Life Sci , vol.74 , pp. 843-853
    • Kobayashi, S.1    Ikeda, K.2    Miyata, K.3
  • 28
    • 1342300075 scopus 로고    scopus 로고
    • In vitro tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in rats and monkeys
    • Abstract 312,. Florence: October 5–9
    • Hatanaka T, Ukai M, Ohtake A, et al.: In vitro tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in rats and monkeys [Abstract 312]. Presented at the International Continence Society Meeting. Florence: October 5–9, 2003.
    • (2003) ]. Presented at the International Continence Society Meeting
    • Hatanaka, T.1    Ukai, M.2    Ohtake, A.3
  • 29
    • 85130786803 scopus 로고    scopus 로고
    • In vivo bladder selective profile of solifenacin succinate (YM905) over salivary gland in mice and rats
    • Abstract 297, Florence: October 5–9, 2003
    • Ohtake A, Hatanaka T, Ikeda K, et al.: In vivo bladder selective profile of solifenacin succinate (YM905) over salivary gland in mice and rats [Abstract 297]. Presented at the International Continence Society Meeting. Florence: October 5–9, 2003.
    • Presented at the International Continence Society Meeting.
    • Ohtake, A.1    Hatanaka, T.2    Ikeda, K.3
  • 30
    • 85130817096 scopus 로고    scopus 로고
    • Multiple dosing with YM905, a novel, bladder-selective antimuscarinic, in healthy men: Safety, tolerability, and pharmacokinetics [Abstract 439]
    • Heidelberg, Germany: August 28–30, 2002
    • Smulders RA, van Alphen W, Visser J, et al.: Multiple dosing with YM905, a novel, bladder-selective antimuscarinic, in healthy men: safety, tolerability, and pharmacokinetics [Abstract 439]. Presented at the International Continence Society Meeting. Heidelberg, Germany: August 28–30, 2002.
    • Presented at the International Continence Society Meeting.
    • Smulders, R.A.1    van Alphen, W.2    Visser, J.3
  • 31
    • 1642538375 scopus 로고    scopus 로고
    • Solifenacin appears effective and well tolerated in patients with symptomatic idiopathic detrusor overactivity in a placebo- and tolterodine-controlled phase-2 dose-finding study
    • PID: 14678372, COI: 1:CAS:528:DC%2BD2cXhtVSjuro%3D
    • Chapple CR, Arano P, Bosch JH, et al.: Solifenacin appears effective and well tolerated in patients with symptomatic idiopathic detrusor overactivity in a placebo- and tolterodine-controlled phase-2 dose-finding study. BJU Int 2004, 93:71–77. DOI: 10.1111/j.1464-410X.2004.04561.x
    • (2004) BJU Int , vol.93 , pp. 71-77
    • Chapple, C.R.1    Arano, P.2    Bosch, J.H.3
  • 32
    • 2942636772 scopus 로고    scopus 로고
    • Darifenacin is well tolerated and provides significant improvement in the symptoms of overactive bladder: a pooled analysis of phase-3 studies [Abstract 487]
    • Results of pooled data are presented from three large multicenter, double-blind, placebo-controlled studies assessing the efficacy, safety, and tolerability of darifenacin
    • Chapple CR: Darifenacin is well tolerated and provides significant improvement in the symptoms of overactive bladder: a pooled analysis of phase-3 studies [Abstract 487]. J Urol 2004, 171(suppl):130. Results of pooled data are presented from three large multicenter, double-blind, placebo-controlled studies assessing the efficacy, safety, and tolerability of darifenacin.
    • (2004) J Urol , vol.171 , pp. 130
    • Chapple, C.R.1
  • 33
    • 0141765276 scopus 로고    scopus 로고
    • Two randomized, double-blind, placebo-controlled, parallel-group, fixed-dose, multicenter studies assess the efficacy and safety of daily oral administration of 10mg YM905 versus placebo in male and female subjects with overactive bladder [Abstract DP43]
    • Gittelman M, Klimberg I, Fincer R, et al.: Two randomized, double-blind, placebo-controlled, parallel-group, fixed-dose, multicenter studies assess the efficacy and safety of daily oral administration of 10mg YM905 versus placebo in male and female subjects with overactive bladder [Abstract DP43]. J Urol 2003, 169(suppl):349.
    • (2003) J Urol , vol.169 , pp. 349
    • Gittelman, M.1    Klimberg, I.2    Fincer, R.3
  • 34
    • 0141430441 scopus 로고    scopus 로고
    • YM905 10mg increases the proportion of male and female patients with overactive bladder who become continent [Abstract DP49]
    • Kaufman J, Aurora CO, Knapp P: YM905 10mg increases the proportion of male and female patients with overactive bladder who become continent [Abstract DP49]. J Urol 2003, 169(suppl):351.
    • (2003) J Urol , vol.169 , pp. 351
    • Kaufman, J.1    Aurora, C.O.2    Knapp, P.3
  • 35
    • 0035512910 scopus 로고    scopus 로고
    • Trospium chloride: an effective drug in the treatment of overactive bladder and detrusor hyper-reflexia
    • PID: 11760782, COI: 1:CAS:528:DC%2BD38XjvVyhtQ%3D%3D
    • Hofner K, Oelke M, Machtens S, Grunewald V: Trospium chloride: an effective drug in the treatment of overactive bladder and detrusor hyper-reflexia. World J Urol 2001, 19:336–343. DOI: 10.1007/s003450100225
    • (2001) World J Urol , vol.19 , pp. 336-343
    • Hofner, K.1    Oelke, M.2    Machtens, S.3    Grunewald, V.4
  • 36
    • 1542441745 scopus 로고    scopus 로고
    • Trospium chloride: A quaternary amine with unique pharmacologic properties
    • PID: 14622495, A comprehensive review on the unique properties of trospium chloride
    • Pak RW, Petrou SP, Staskin DR: Trospium chloride: A quaternary amine with unique pharmacologic properties. Curr Urol Rep 2003, 4:436–440. A comprehensive review on the unique properties of trospium chloride. DOI: 10.1007/s11934-003-0023-1
    • (2003) Curr Urol Rep , vol.4 , pp. 436-440
    • Pak, R.W.1    Petrou, S.P.2    Staskin, D.R.3
  • 37
    • 0342699560 scopus 로고    scopus 로고
    • Trospium chloride: an effective option for medical treatment of bladder overactivity
    • PID: 10839466, COI: 1:CAS:528:DC%2BD38XovVykuw%3D%3D
    • Fusgen I, Hauri D: Trospium chloride: an effective option for medical treatment of bladder overactivity. Int J Clin Pharmacol Ther 2000, 38:223–234.
    • (2000) Int J Clin Pharmacol Ther , vol.38 , pp. 223-234
    • Fusgen, I.1    Hauri, D.2
  • 40
    • 0032461855 scopus 로고    scopus 로고
    • Trospium chloride in patients with motor urge syndrome: a double-blind, randomized, multicenter, placebo-controlled study
    • Alloussi S, Laval KU, Eckert R, et al.: Trospium chloride in patients with motor urge syndrome: a double-blind, randomized, multicenter, placebo-controlled study. J Clin Res 1998, 1:439–451.
    • (1998) J Clin Res , vol.1 , pp. 439-451
    • Alloussi, S.1    Laval, K.U.2    Eckert, R.3
  • 41
    • 0025993669 scopus 로고
    • Effect of trospium chloride on urodynamic parameters in patients with detrusor hyperreflexia due to spinal cord injuries: a multicenter, placebocontrolled, double-blind trial
    • PID: 1771701, COI: 1:STN:280:DyaK387isVKiug%3D%3D
    • Stohrer M, Bauer P, Giannetti BM, et al.: Effect of trospium chloride on urodynamic parameters in patients with detrusor hyperreflexia due to spinal cord injuries: a multicenter, placebocontrolled, double-blind trial. Urol Int 1991, 47:138–143. DOI: 10.1159/000282207
    • (1991) Urol Int , vol.47 , pp. 138-143
    • Stohrer, M.1    Bauer, P.2    Giannetti, B.M.3
  • 42
    • 0028953953 scopus 로고
    • Trospium chloride versus oxybutynin: a randomized, double-blind, multicenter trial in the treatment of detrusor hyper-reflexia
    • PID: 7788255, COI: 1:STN:280:DyaK2MzgvVSjsw%3D%3D
    • Madersbacher H, Stohrer M, Richter R, et al.: Trospium chloride versus oxybutynin: a randomized, double-blind, multicenter trial in the treatment of detrusor hyper-reflexia. Br J Urol 1995, 75:452–456.
    • (1995) Br J Urol , vol.75 , pp. 452-456
    • Madersbacher, H.1    Stohrer, M.2    Richter, R.3
  • 43
    • 0141566414 scopus 로고    scopus 로고
    • Controlled, doubleblind, multicenter clinical trial to investigate long-term tolerability and efficacy of trospium chloride in patients with detrusor instability
    • PID: 12811500, COI: 1:CAS:528:DC%2BD3sXksFGluro%3D
    • Halaska M, Ralph G, Wiedemann A, et al.: Controlled, doubleblind, multicenter clinical trial to investigate long-term tolerability and efficacy of trospium chloride in patients with detrusor instability. World J Urol 2003, 20:392–399.
    • (2003) World J Urol , vol.20 , pp. 392-399
    • Halaska, M.1    Ralph, G.2    Wiedemann, A.3
  • 44
    • 0000926777 scopus 로고    scopus 로고
    • Tolerability and efficacy of trospium chloride in a long-term treatment (52 weeks) in patients with urge syndrome: a double-blind, controlled, multicenter clinical trial
    • Hofner K, Halaska M, Primus GL, et al.: Tolerability and efficacy of trospium chloride in a long-term treatment (52 weeks) in patients with urge syndrome: a double-blind, controlled, multicenter clinical trial. Neurourol Urodyn 2000, 19:487–488.
    • (2000) Neurourol Urodyn , vol.19 , pp. 487-488
    • Hofner, K.1    Halaska, M.2    Primus, G.L.3
  • 45
    • 2442562363 scopus 로고    scopus 로고
    • Trospium chloride improves overactive bladder symptoms: a multicenter phase III trial
    • PID: 15126811, COI: 1:CAS:528:DC%2BD2cXkvVWhsrY%3D
    • Zinner N, Gittelman M, Harris R, et al.: Trospium chloride improves overactive bladder symptoms: a multicenter phase III trial. J Urol 2004, 171:2311–2315. DOI: 10.1097/01.ju.0000127742.73136.0c
    • (2004) J Urol , vol.171 , pp. 2311-2315
    • Zinner, N.1    Gittelman, M.2    Harris, R.3
  • 46
    • 0035010117 scopus 로고    scopus 로고
    • Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system
    • PID: 11402632, COI: 1:CAS:528:DC%2BD3MXks1Kgsrc%3D
    • Todorova A, Vonderheid-Guth B, Dimpfel W: Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system. J Clin Pharmacol 2001, 41:636–644. DOI: 10.1177/00912700122010528
    • (2001) J Clin Pharmacol , vol.41 , pp. 636-644
    • Todorova, A.1    Vonderheid-Guth, B.2    Dimpfel, W.3
  • 47
    • 0026756817 scopus 로고
    • Effect of 5-HT receptor and adrenoceptor antagonists on micturition in conscious cats
    • PID: 1360901, COI: 1:CAS:528:DyaK38Xmt1Kqsrs%3D
    • Espey MJ, Downie JW, Fine A: Effect of 5-HT receptor and adrenoceptor antagonists on micturition in conscious cats. Eur J Pharmacol 1992, 221:167–170. DOI: 10.1016/0014-2999(92)90788-6
    • (1992) Eur J Pharmacol , vol.221 , pp. 167-170
    • Espey, M.J.1    Downie, J.W.2    Fine, A.3
  • 48
    • 0021151538 scopus 로고
    • Experimental evidence for a central nervous system site of action in the effect of alphaadrenergic blockers on the external urinary sphincter
    • PID: 6145805, COI: 1:CAS:528:DyaL2cXlt1ekurk%3D
    • Gajewski J, Downie JW, Awad SA: Experimental evidence for a central nervous system site of action in the effect of alphaadrenergic blockers on the external urinary sphincter. J Urol 1984, 132:403–409.
    • (1984) J Urol , vol.132 , pp. 403-409
    • Gajewski, J.1    Downie, J.W.2    Awad, S.A.3
  • 49
    • 0026575546 scopus 로고
    • Serotoninergic, noradrenergic, and peptidergic innervation of Onuf’s nucleus of normal and transected spinal cords of baboons (Papio)
    • PID: 1374763, COI: 1:STN:280:DyaK383lvFKlsA%3D%3D
    • Rajaofetra N, Passagia JG, Marlier L, et al.: Serotoninergic, noradrenergic, and peptidergic innervation of Onuf’s nucleus of normal and transected spinal cords of baboons (Papio). J Comp Neurol 1992, 318:1–17. DOI: 10.1002/cne.903180102
    • (1992) J Comp Neurol , vol.318 , pp. 1-17
    • Rajaofetra, N.1    Passagia, J.G.2    Marlier, L.3
  • 50
    • 0029027862 scopus 로고
    • Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neuronal control of lower urinary tract function in the chlorolose-anesthetized female cat
    • PID: 7636716, COI: 1:CAS:528:DyaK2MXnsFSjur4%3D
    • Thor KB, Katofiase M: Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neuronal control of lower urinary tract function in the chlorolose-anesthetized female cat. J Pharmacol Exp Ther 1995, 274:1014–1024.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 1014-1024
    • Thor, K.B.1    Katofiase, M.2
  • 51
    • 0033674519 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of duloxetine, a dual-serotonin and norepinephrine reuptake inhibitor
    • PID: 10664922, COI: 1:CAS:528:DC%2BD3cXivFOmt70%3D
    • Sharma A, Goldberg MJ, Cerimele BJ: Pharmacokinetics and safety of duloxetine, a dual-serotonin and norepinephrine reuptake inhibitor. J Clin Pharmacol 2000, 40:161–167. DOI: 10.1177/00912700022008810
    • (2000) J Clin Pharmacol , vol.40 , pp. 161-167
    • Sharma, A.1    Goldberg, M.J.2    Cerimele, B.J.3
  • 52
    • 0041856533 scopus 로고    scopus 로고
    • Metabolism, excretion, and pharmacokinetics of duloxetine in healthy human subjects
    • PID: 12920170, COI: 1:CAS:528:DC%2BD3sXmslKlu7w%3D
    • Lantz RJ, Gillespie TA, Rash TJ, et al.: Metabolism, excretion, and pharmacokinetics of duloxetine in healthy human subjects. Drug Metab Dispos 2003, 31:1142–1150. DOI: 10.1124/dmd.31.9.1142
    • (2003) Drug Metab Dispos , vol.31 , pp. 1142-1150
    • Lantz, R.J.1    Gillespie, T.A.2    Rash, T.J.3
  • 53
    • 0036074281 scopus 로고    scopus 로고
    • Duloxetine versus placebo in the treatment of stress urinary incontinence
    • PID: 12114886, COI: 1:CAS:528:DC%2BD38XmtlWrtLk%3D, The first placebo-controlled efficacy trial of duloxetine. Duloxetine resulted statistically significant dose-dependent decreases IEF with corresponding improvements observed PGI-I and I-QOL scores
    • Norton PA, Zinner NR, Yalcin I, et al.: Duloxetine versus placebo in the treatment of stress urinary incontinence. Am J Obstet Gynecol 2002, 187:40–48. The first placebo-controlled efficacy trial of duloxetine. Duloxetine resulted in statistically significant dose-dependent decreases in IEF with corresponding improvements observed in PGI-I and I-QOL scores. DOI: 10.1067/mob.2002.124840
    • (2002) Am J Obstet Gynecol , vol.187 , pp. 40-48
    • Norton, P.A.1    Zinner, N.R.2    Yalcin, I.3
  • 54
    • 0041691081 scopus 로고    scopus 로고
    • Duloxetine versus placebo for the treatment of North American women with stress urinary incontinence
    • PID: 14501737, COI: 1:CAS:528:DC%2BD3sXovFOhsrg%3D
    • Dmochowski RR, Miklos JR, Norton PA, et al.: Duloxetine versus placebo for the treatment of North American women with stress urinary incontinence. J Urol 2003, 170:1259–1263. DOI: 10.1097/01.ju.0000080708.87092.cc
    • (2003) J Urol , vol.170 , pp. 1259-1263
    • Dmochowski, R.R.1    Miklos, J.R.2    Norton, P.A.3
  • 55
    • 1542374616 scopus 로고    scopus 로고
    • Duloxetine versus placebo in the treatment of European and Canadian women with stress urinary incontinence
    • COI: 1:CAS:528:DC%2BD2cXis1ShtLY%3D
    • Van Kerrebroeck P, Abrams P, Lange R, et al.: Duloxetine versus placebo in the treatment of European and Canadian women with stress urinary incontinence. BJOG 2004, 111:249–257. DOI: 10.1111/j.1471-0528.2004.00067.x
    • (2004) BJOG , vol.111 , pp. 249-257
    • Van, K.P.1    Abrams, P.2    Lange, R.3
  • 56
    • 1342310038 scopus 로고    scopus 로고
    • Duloxetine vs placebo in the treatment of stress urinary incontinence: a four-continent randomized clinical trial
    • PID: 14764128, COI: 1:CAS:528:DC%2BD2cXis1ShsLs%3D
    • Millard RJ, Moore K, Renchen R, et al.: Duloxetine vs placebo in the treatment of stress urinary incontinence: a four-continent randomized clinical trial. BJU Int 2004, 93:311–318. DOI: 10.1111/j.1464-410X.2004.04607.x
    • (2004) BJU Int , vol.93 , pp. 311-318
    • Millard, R.J.1    Moore, K.2    Renchen, R.3
  • 57
    • 85130812165 scopus 로고    scopus 로고
    • Controlled trial of duloxetine alone, pelvic floor muscle training alone, combined treatment, and no treatment in women with stress urinary incontinence [Abstract]
    • Weston FL, Elser DM, Lawn O, et al.: Controlled trial of duloxetine alone, pelvic floor muscle training alone, combined treatment, and no treatment in women with stress urinary incontinence [Abstract]. AUA 2004, 1239.
    • (2004) AUA , pp. 1239
    • Weston, F.L.1    Elser, D.M.2    Lawn, O.3
  • 58
    • 1842515339 scopus 로고    scopus 로고
    • Duloxetine in the long-term treatment of major depressive disorder
    • Raskin J, Goldstein DJ, Mallinckrodt CH, et al.: Duloxetine in the long-term treatment of major depressive disorder. J Clin Psychiatry 2004, 64:1237–1244. DOI: 10.4088/JCP.v64n1015
    • (2004) J Clin Psychiatry , vol.64 , pp. 1237-1244
    • Raskin, J.1    Goldstein, D.J.2    Mallinckrodt, C.H.3
  • 59
    • 0142043025 scopus 로고    scopus 로고
    • Efficacy and tolerability of duloxetine, a novel dual reuptake inhibitor, in the treatment of major depressive disorder
    • PID: 14552654, COI: 1:CAS:528:DC%2BD3sXptFSjsbY%3D
    • Schatzberg AF: Efficacy and tolerability of duloxetine, a novel dual reuptake inhibitor, in the treatment of major depressive disorder. J Clin Psychiatry 2003, 64:30–37. DOI: 10.4088/JCP.v64n0107
    • (2003) J Clin Psychiatry , vol.64 , pp. 30-37
    • Schatzberg, A.F.1
  • 60
    • 0037905794 scopus 로고    scopus 로고
    • Prospective, randomized, double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder: results of the OPERA trial
    • PID: 12934777, COI: 1:CAS:528:DC%2BD3sXkvFWrtr0%3D
    • Diokno AC, Appell RA, Sand PK, et al.: Prospective, randomized, double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder: results of the OPERA trial. Mayo Clin Proc 2003, 78:687–695.
    • (2003) Mayo Clin Proc , vol.78 , pp. 687-695
    • Diokno, A.C.1    Appell, R.A.2    Sand, P.K.3
  • 61
    • 0035088137 scopus 로고    scopus 로고
    • Prospective, randomized, controlled trial of extended-release oxybutynin chloride and tolterodine tartrate in the treatment of overactive bladder: results of the OBJECT Study
    • Appell RA, Sand P, Dmochowski R, et al.: Prospective, randomized, controlled trial of extended-release oxybutynin chloride and tolterodine tartrate in the treatment of overactive bladder: results of the OBJECT Study. Mayo Clin Proc 2001, 76:359–363. DOI: 10.4065/76.4.358
    • (2001) Mayo Clin Proc , vol.76 , pp. 359-363
    • Appell, R.A.1    Sand, P.2    Dmochowski, R.3
  • 62
    • 0032829435 scopus 로고    scopus 로고
    • Once daily controlled versus immediate-release oxybutynin chloride for urge urinary incontinence
    • PID: 10332441, COI: 1:CAS:528:DyaK1MXjtlyrur8%3D
    • Anderson RU, Mobley D, Blank B, et al.: Once daily controlled versus immediate-release oxybutynin chloride for urge urinary incontinence. J Urol 1999, 161:1809–1812. DOI: 10.1016/S0022-5347(05)68810-6
    • (1999) J Urol , vol.161 , pp. 1809-1812
    • Anderson, R.U.1    Mobley, D.2    Blank, B.3
  • 63
    • 0035126767 scopus 로고    scopus 로고
    • Tolterodine oncedaily: superior efficacy and tolerability in the treatment of overactive bladder
    • Van Kerrebroeck P, Kreder K, Jonas U, et al.: Tolterodine oncedaily: superior efficacy and tolerability in the treatment of overactive bladder. Urology 2001, 57:414–421. DOI: 10.1016/S0090-4295(00)01113-4
    • (2001) Urology , vol.57 , pp. 414-421
    • Van, K.P.1    Kreder, K.2    Jonas, U.3
  • 64
    • 0036078113 scopus 로고    scopus 로고
    • Efficacy and safety of transdermal oxybutynin in patients with urge and mixed urinary incontinence
    • PID: 12131314, COI: 1:CAS:528:DC%2BD38XmtFWhtbo%3D
    • Dmochowski RR, Davila GW, Zinner NR, et al.: Efficacy and safety of transdermal oxybutynin in patients with urge and mixed urinary incontinence. J Urol 2002, 168:580–586. DOI: 10.1016/S0022-5347(05)64684-8
    • (2002) J Urol , vol.168 , pp. 580-586
    • Dmochowski, R.R.1    Davila, G.W.2    Zinner, N.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.