Duloxetine versus placebo for the treatment of North American women with stress urinary incontinence

Journal of Urology

Volumn 170, Issue 4 I, 2003, Pages 1259-1263

  Dmochowski, Roger R ^a   Miklos, John R ^b   Norton, Peggy A ^c   Zinner, Norman R ^d   Yalcin, Ilker ^e   Bump, Richard C ^e  

^a VANDERBILT UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d Doctors Urology Group   (United States)

^e ELI LILLY AND COMPANY   (United States)

Author keywords

Bladder; Quality of life; Questionnaires; Serotonin reuptake inhibitors; Urinary incontinence, stress

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; DULOXETINE; NORADRENALIN UPTAKE INHIBITOR; PLACEBO; SEROTONIN 2 RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGED; ARTICLE; BLADDER CAPACITY; BLADDER SPHINCTER; CIRCADIAN RHYTHM; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; FATIGUE; FEMALE; HEADACHE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MOTONEURON; NAUSEA; NOCTURIA; NORTH AMERICA; PRIORITY JOURNAL; PUDENDAL NERVE; QUALITY OF LIFE; SIDE EFFECT; SOMNOLENCE; STRESS INCONTINENCE; SYMPTOM; TREATMENT OUTCOME; URGE INCONTINENCE; VERTIGO; VISUAL IMPAIRMENT; XEROSTOMIA;

EID: 0041691081     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000080708.87092.cc     Document Type: Article

References (20)

1. Abrams, P., Cardozo, L., Fall, M., Griffiths, D., Rosier, P., Ulmsten, U. et al: The standardisation of terminology of lower urinary tract function: report from the Standardisation Subcommittee of the International Continence Society. Neurourol Urodyn, 21: 167, 2002
2. Hampel, C., Wienhold, D., Benken, N., Eggersmann, C. and Thuroff, J. W.: Definition of overactive bladder and epidemiology of urinary incontinence. Urology, 50: 4, 1997
3. Espey, M. J., Du, H. J. and Downie, J. W.: Serotonergic modulation of spinal ascending activity and sacral reflex activity evoked by pelvic nerve stimulation in cats. Brain Res, 798: 101, 1998
4. Danuser, H. and Thor, K. B.: Spinal 5-HT2 receptor-mediated facilitation of pudendal nerve reflexes in the anaesthetized cat. Br J Pharmacol, 118: 150, 1996
5. Gajewski, J., Downie, J. W. and Awad, S. A.: Experimental evidence for a central nervous system site of action in the effect of alpha-adrenergic blockers on the external urinary sphincter. J Urol, 132: 403, 1984
6. Downie, J. W. and Bialik, G. J.: Evidence for a spinal site of action of clonidine on somatic and viscerosomatic reflex activity evoked on the pudendal nerve in cats. J Pharmacol Exp Ther, 246: 352, 1988
7. Downie, J. W., Espey, M. J. and Gajewski, J. B.: Alpha 2-adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat. Eur J Pharmacol, 195: 301, 1991
8. Espey, M. J., Downie, J. W. and Fine, A.: Effect of 5-HT receptor and adrenoceptor antagonists on micturition in conscious cats. Eur J Pharmacol, 221: 167, 1992
9. Thor, K. B. and Katofiasc, M. A.: Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat. J Pharmacol Exp Ther, 274: 1014, 1995
10. Katofiasc, M. A., Nissen, J., Audia, J. E. and Thor, K. B.: Comparison of the effects of serotonin selective, norepinephrine selective and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats. Life Sci, 71: 1227, 2002
11. Norton, P. A., Zinner, N. R., Yalcin, I. and Bump, R. C.: Duloxetine versus placebo in the treatment of stress urinary incontinence. Am J Obstet Gynecol, 187: 40, 2002
12. Patrick, D. L., Martin, M. L., Bushnell, D. M., Yalcin, I., Wagner, T. H. and Buesching, D. P.: Quality of life of women with urinary incontinence: further development of the incontinence quality of life instrument (I-QOL). Urology, 53: 71, 1999
13. Donovan, J. L., Badia, X., Corcos, J., Gotoh, M., Kelleher, C., Naughton, M. et al: Symptom and quality of life assessment. In: Incontinence. 2nd International Consultation on Incontinence, Paris, July 1-5, 2001. Edited by P. Abrams, L. Cardozo, S. Khoury and A Wein. Plymouth, United Kingdom: Health Publications, Ltd., pp. 267-316, 2002
14. Yalcin, I. and Bump, R. C.: Validation of two global impression questionnaires for incontinence. Am J Obstet Gynecol, 189: 98, 2003
15. Beck, A. T., Steer, R. A. and Brown, G. K.: Manual for the Beck Depression Inventory-II. San Antonio, Texas: Psychological Corp., 1996
16. Hannestad, Y. S., Rortveit, G., Sandvik, H. and Hunskaar, S.: A community-based epidemiological survey of female urinary incontinence: the Norwegian EPINCONT study. Epidemiology of incontinence in the county of Nord-Trondelag. J Clin Epidemiol, 53: 1150, 2000
17. Brown, J. S., Waetjen, L. E., Subak, L. L., Thome, D. H., Van den Eeden, S. and Vittinghoff, E.: Pelvic organ prolapse surgery in the United States, 1997. Am J Obstet Gynecol, 186: 712, 2002
18. Lagro-Janssen, T. and Van Weel, C.: Long-term effect of treatment of female incontinence in general practice. Br J Gen Prac, 48: 1735, 1998
19. Kernan, W. N., Viscoli, C. M., Brass, L. M., Broderick, J. P., Brott, T., Feldmann, E. et al: Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med, 343: 1826, 2000
20. Fleming, G. A.: The FDA, regulation, and the risk of stroke. N Engl J Med, 343: 1886, 2000