S-15176 reduces the hepatic injury in rats subjected to experimental ischemia and reperfusion

European Journal of Pharmacology

Volumn 406, Issue 2, 2000, Pages 281-292

  Settaf, Abdellatif ^a   Zahidy, Mouna ^a   Elimadi, Aziz ^b   Sapena, Rosa ^b   Alsamad, Issam Abd ^c   Tillement, Jean Paul ^b   Morin, Didier ^b  

^a MOHAMMED V UNIVERSITY   (Morocco)

^b FACULTÉ DE MÉDECINE   (France)

^c CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

Author keywords

Antioxidant; ATP; Bile flow; Glutathione; Ischemia reperfusion; Liver; Protective effect; Rat

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIVER PROTECTIVE AGENT; N [(3,5 DI TERTIOBUTYL 4 HYDROXY 1 THIOPHENYL)] 3 PROPYL N' (2,3,4 TRIMETHOXYBENZYL)PIPERAZINE; S 15176; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BILE FLOW; CELL PROTECTION; CONTROLLED STUDY; DRUG STRUCTURE; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER ISCHEMIA; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ADENOSINE TRIPHOSPHATE; ANIMAL; ANTIOXIDANTS; BILE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; GLUTATHIONE DISULFIDE; ISCHEMIA; LIVER; MALE; PIPERAZINES; RATS; REPERFUSION INJURY; SUPPORT, NON-U.S. GOV'T;

EID: 0034644875     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00599-9     Document Type: Article

References (41)

1. Akerboom T.P.M. Assays of glutathione, glutathione disulfide and glutathione mixed disulfide in biological samples. Methods Enzymol. 77:1981;373-382.
2. Akerboom T.P.M., Bilzer M., Sies H. The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver. J. Biol. Chem. 257:1982;4248-4252.
3. Bernardi P., Colonna R., Costantini P., Eriksson O., Fontaine E., Ichas F., Massari S., Nicolli A., Petronilli V., Scorrano L. The mitochondrial permeability transition. BioFactors. 8:1998;273-281.
4. Braughler J.M., Duncan L.A., Chase R.L. The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation. J. Biol. Chem. 261:1986;10282-10289.
5. Camargo C.A. Jr., Madden J.F., Gao W., Selvan R.S., Clavien P.A. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology. 26:1997;1513-1520.
6. Cassidy W.M., Reynolds T.B. Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury. J. Clin. Gastroenterol. 19:1994;118-121.
7. Choi D.W. Ischemia-induced neuronal apoptosis. Curr. Opin. Neurobiol. 6:1996;667-672.
8. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341:1999;233-249.
9. Denno R., Takabayashi A., Sugano M., Awane M., Jin M.B., Morimoto T., Tanaka K., Yamaoka Y., Kobayashi N., Ozawa K. The ratio reduced glutathione/oxidized glutathione is maintained in the liver during short-term hepatic hypoxia. J. Gastroenterol. 30:1995;338-346.
10. 2+-dependent mitochondrial swelling. Fundam. Clin. Pharmacol. 11:1997;440-447.
11. Elimadi A., Settaf A., Morin D., Sapena R., Lamchouri F., Cherrah Y., Tillement J.P. Trimetazidine counteracts the hepatic injury associated with ischemia-reperfusion by preserving mitochondrial function. J. Pharmacol. Exp. Ther. 286:1998;23-28.
12. Fujikawa M., Kamiike W., Hatanaka N., Shimizu S., Akashi A., Miyata M., Kurosawa K., Yoshida Y., Tagawa K., Matsuda H. Changes in biliary glutathione level during ischemia-reperfusion of rat liver. J. Surg. Res. 57:1994;569-573.
13. Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312.
14. Hauet T., Mothes D., Goujon J.M., Caritez J.C., Carretier M., Le Moyec L., Eugene M., Tillement J.P. Trimetazidine prevents renal injury in the isolated perfused pig kidney exposed to prolonged cold ischemia. Transplantation. 64:1997;1082-1086.
15. Jaeschke H., Farhood A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am. J. Physiol. 260:1991;G355-G362.
16. Jaeschke H., Smith Ch.V., Mitchell J.R. Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver. J. Clin. Invest. 81:1988;1240-1246.
17. Jaworec D., Greber W., Bergmeyer H.V. Adenosine 5′-triphosphate. Bergmeyer H.V. 2nd edn. Methods of Enzymatic Analysis. vol. 4:1974;2097-2101 Academic Press, New York.
18. Kamiike W., Watanabe F., Hashimoto T., Tagawa K., Ikeda Y., Nakao K., Kawashima Y. Changes in cellular levels of ATP and its catabolites in ischemic rat liver. J. Biochem. (Tokyo). 91:1982;1349-1356.
19. Karwinski W., Soreide O. Allopurinol improves scavenging ability of the liver after ischemia/reperfusion injury. Liver. 17:1997;139-143.
20. Karwinski W., Garcia R., Helton S.W. Protective effect of the calcium blocker verapamil on hepatic function following warm ischemia. J. Surg. Res. 64:1996;150-155.
21. Karwinski W., Husoy A.M., Farstad M., Soreide O. Sixty minutes of normothermic ischemia in the rat liver: correlation between adenine nucleotides and bile excretion. J. Surg. Res. 46:1989;99-103.
22. Kohli V., Selzner M., Madden J.F., Bentley R.C., Clavien P.A. Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver. Transplantation. 67:1999;1099-1105.
23. Kroemer G., Dallaporta B., Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol. 60:1998;619-642.
24. Kurokawa T., Kobayashi H., Nonami T., Harada A., Nakao A., Takagi H. Mitochondrial glutathione redox and energy producing function during liver ischemia and reperfusion. J. Surg. Res. 66:1996;1-5.
25. Lauterburg B.H., Smith C.V., Hughes H., Mitchell J.R. Biliary excretion of glutathione disulfide in the rat. J. Clin. Invest. 73:1984;124-133.
26. Majno G., Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol. 146:1995;3-15.
27. Marubayashi S., Dohi K., Kawasaki T. Role of free radicals in hepatic reperfusion injury. Ann. N. Y. Acad. Sci. 723:1994;368-370.
28. Mathews W.R., Guido D.M., Fisher M.A., Jaeschke H. Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia. Free Radical Biol. Med. 16:1994;763-770.
29. McCord J.M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 312:1985;159-163.
30. Metzger J., Lauterburg B.H. Postischemic ATP levels predict hepatic function 24 hours following ischemia in the rat. Experientia. 44:1988;455-457.
31. Nauta R.J., Uribe M., Tsimoyiannis E., Walsh D.H., Miller D., Butterfield A. Description of a chronic in vivo model for the study of warm hepatic ischemia/reperfusion injury. Surg. Res. Commun. 6:1989;241-246.
32. Nishimura T., Yoshida Y., Watanabe F., Koseki M., Nishida T., Tagawa K., Kawashima Y. Blood level of mitochondrial aspartate aminotransferase as an indicator of the extent of ischemic necrosis of the rat liver. Hepatology. 6:1986;701-707.
33. Nishizawa H., Egawa H., Inomata Y., Uemoto S., Asonuma K., Kiuchi T., Yamaoka Y., Tanaka K. Efficiency of pentoxifylline in donor pretreatment in rat liver transplantation. J. Surg. Res. 72:1997;170-176.
34. Okuaki Y., Miyazaki H., Zeniya M., Ishikawa T., Ohkawa Y., Tsuno S., Sakaguchi M., Hara M., Takahashi H., Toda G. Splenectomy-reduced hepatic injury induced by ischemia/reperfusion in the rat. Liver. 16:1996;188-194.
35. Poggetti R.S., Moore E.E., Moore F.A., Koike K., Tuder R., Anderson B.O., Banerjee A. Quantifying oxidative injury in the liver. Am. J. Physiol. 268:1995;G471-G479.
36. Sakr M.F., Zetti G.M., Hassanein T.I., Farghali H., Nalesnik M.A., Gavader J.S., Starzl T.E., Van Thiel D.H. FK 506 ameliorates the hepatic injury associated with ischemia and reperfusion in rats. Hepatology. 13:1991;947-951.
37. Settaf A., Morin D., Lamchouri F., Elimadi A., Cherrah Y., Tillement J.P. Trimetazidine ameliorates the hepatic injury associated with ischemia reperfusion in rats. Pharmacol. Res. 39:1999;211-216.
38. Xia Z.F., Horton J.W., Zhao P.Y., Babcock E.E., Sherry A.D., Malloy C.R. Effects of ischemia on intracellular sodium and phosphates in the in vivo rat liver. J. Appl. Physiol. 81:1996;1395-1403.
39. Yamamoto S., Shimizu K., Oonishi I., Hasebe K., Takamura H., Inoue T., Muraoka K., Tani T., Hashimoto T., Yagi M. Genistein suppresses cellular injury following hepatic ischemia/reperfusion. Transplant. Proc. 28:1996;1111-1115.
40. Zini I., Tomasi A., Grimaldi R., Vannini V., Agnati L.F. Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis. Neurosci. Lett. 138:1992;279-282.
41. Zoratti M., Szabo' I. The mitochondrial permeability transition. Biochim. Biophys. Acta. 1241:1995;139-176.