Alcohol-acetaminophen syndrome

Postgraduate Medicine

Volumn 107, Issue 1, 2000, Pages 189-195

  Draganov, Peter ^a   Durrence, Hugh ^a   Cox, Christopher ^a   Reuben, Adrian ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; PARACETAMOL;

ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ALCOHOL METABOLISM; ARTICLE; CLINICAL FEATURE; DRUG METABOLISM; DRUG OVERDOSE; HUMAN; LABORATORY TEST; LIVER FAILURE; LIVER FUNCTION TEST; LIVER TOXICITY; LIVER TRANSPLANTATION; SYNDROME DELINEATION; TREATMENT OUTCOME;

EID: 0033958499     PISSN: 00325481     EISSN: None     Source Type: Journal    
DOI: 10.3810/pgm.2000.01.831     Document Type: Article

References (20)

1. Rumack BH, Peterson RC, Koch GG, et al. Acetaminophen overdose: 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 1981;141:380-5
2. Zimmeerman HJ, Maddrey WC, Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. Hepatology 1998;22(3):767-73
3. Lee WM. Acute liver failure. Am J Med 1994;96(Suppl 1A):1A-5S-9S
4. Lee WM. Drug-induced hepatotoxicity. N Engl J Med 1995;333(17):1118-27
5. Seeff LB, Cuccherini BA, Zimmerman HJ, et al. Acetaminophen hepatotoxicity in alcoholics: a therapeutic misadventure. Ann Intern Med 1986;104(3):399-404
6. Schiødt, PV, Rochling FA, Casey DL, et al. Acetaminophin toxicity in an urban county hospital. N Engl Med 1997; 337(16):1112-7
7. Seiferr CF, Lucas DS, Vondracek TG, et al. Patterns of acetaminophen use in alcoholic patients. Pharmacotherapy 1993; 13(4):391-5
8. Whitcomb DC, Block GD, Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 1994;272(23): 1845-50
9. Nelson SD. Molecular mechanisms of the hepatotoxicity caused by acetaminophe. Semin Liv Dis 1990;10(4):267-78
10. Mitchell JR, Jollow DJ, Potter WZ, et al. Accetaminophen-induced hepatic necrosis IV. Protective role of glutathione. J Pharmacol Exp Ther 1973;187(1):211-7
11. Slattery JT, Nelson SD, Thummel KE. The compex interaction between ethanol and acetaminophen. Clin Pharmacol Ther 1996;60(3):241-6
12. Licht H, Seeff LB, Zimmerman HJ. Apparent penetration of acetaminophen hepatotoxicity by alcohol. Ann Intern Med 1980;92:511
13. Maddrey WC. Hepatic effects of acetaminophen: enhanced toxicity in alcoholics. J Clin Gastroenterol 1987;9(2):180-5
14. Perrot N, Nalpas B. Yang CS, et al. Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake. Eur J Clin Invest 1989;19:549-55
15. Makin AJ, Wendon J, Williams R.A. 7-year experience of severe aceraminophen-induced hepatotoxicity (197-1993). Gastroenterology 1995;109(6):1907-16
16. Keays R, Harrison PM, Wendon JA. et al. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial BMJ 1991; 303:1026-9
17. Harrison PM, Keays R, Bray GP, et al. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetyleysteine. Lancet 1990;335:1572-3
18. De Roos FJ, Hoffman RS. Drug-induced hepatotoxicity. (Letter) N Engl J Med 1996;334(13):863
19. Lee WM. Drug-induced hepatotoxicity (Letter) N Engl J Med 1996;334(13):864
20. O'Grady JG, Gimson AES, O'Brien CJ, et al. Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure. Gastroenterology 1988;94:1186-92