Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains

Biological and Pharmaceutical Bulletin

Volumn 27, Issue 4, 2004, Pages 531-537

  Sasaki, Shigeki ^a,c   Kurosaki, Fumie ^a   Haradahira, Terushi ^b,c   Yamamoto, Fumihiko ^a,c   Maeda, Jun ^b   Okauchi, Takashi ^b   Suzuki, Kazutoshi ^b   Suhara, Tetsuya ^b,c   Maeda, Minoru ^a,c  

^a KYUSHU UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

11C labelling; Bis(phenylalkyl)amine; Brain distribution; Inhibition experiment; N methly D aspartate (NMDA) receptor antagonist; Polyamine binding site

Indexed keywords

AMINE; IFENPRODIL; LIGAND; METHYL IODIDE; N [3 (4 HYDROXYPHENYL)BUTYL] 3 (4 METHOXYPHENYL)BUTYLAMINE C 11; N [3 (4 HYDROXYPHENYL)PROPYL] 3 (4 METHOXYPHENYL)PROPYLAMINE C 11; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENOL; SPERMINE; TRACER; TRAXOPRODIL; UNCLASSIFIED DRUG; ZINC ION; BUTYLAMINE; CARBON; N (3 (4 HYDROXYPHENYL)BUTYL) 3 (4 METHOXYPHENYL)BUTYLAMINE; N (3 (4 HYDROXYPHENYL)PROPYL) 3 (4 METHOXYPHENYL)PROPYLAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N-(3-(4-HYDROXYPHENYL)BUTYL)-3-(4-METHOXYPHENYL)BUTYLAMINE; N-(3-(4-HYDROXYPHENYL)PROPYL)-3-(4-METHOXYPHENYL)PROPYLAMINE; NMDA RECEPTOR A1; PIPERIDINE DERIVATIVE; PROPYLAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; BRAIN SLICE; CONTROLLED STUDY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MONKEY; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RODENT; STATISTICAL SIGNIFICANCE; STEREOCHEMISTRY; ANIMAL; BINDING SITE; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; MACACA; MALE; METABOLISM; SPRAGUE DAWLEY RAT; SYNTHESIS; TISSUE DISTRIBUTION;

AMINES; ANIMALS; BINDING SITES; BRAIN; BUTYLAMINES; CARBON RADIOISOTOPES; INJECTIONS, INTRAVENOUS; ISOTOPE LABELING; MACACA MULATTA; MALE; MICE; PIPERIDINES; PROPYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPERMINE; TISSUE DISTRIBUTION;

EID: 16544377925     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.27.531     Document Type: Article

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