메뉴 건너뛰기




Volumn 27, Issue 5, 2004, Pages 531-538

Effects of polysaccharide ginsan from Panax ginseng on liver function

Author keywords

Cytochrome P450; Ginsan; Heme oxygenase; Non protein thiols; Polysaccharide

Indexed keywords

GINSAN; PLANT EXTRACT; POLYSACCHARIDE;

EID: 16544377350     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02980127     Document Type: Article
Times cited : (24)

References (50)
  • 1
    • 0027443904 scopus 로고
    • Cytokines downregulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture
    • Abdel-Razzak, Z., Loyer, P., Fautrel, A., Gautier, J. C., Corcos, L., Turlin, B., Beaune, P., and Guillouzo, A., Cytokines downregulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol. Pharmacol., 44, 707-715 (1993).
    • (1993) Mol. Pharmacol. , vol.44 , pp. 707-715
    • Abdel-Razzak, Z.1    Loyer, P.2    Fautrel, A.3    Gautier, J.C.4    Corcos, L.5    Turlin, B.6    Beaune, P.7    Guillouzo, A.8
  • 3
    • 0026033907 scopus 로고
    • Induction of heme oxygenase: A general response to oxidant stress in cultured mammalian cells
    • Applegate, L. A., Luscher, P., and Tyrrell, R. M., Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells. Cancer Res., 51, 974-978 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 974-978
    • Applegate, L.A.1    Luscher, P.2    Tyrrell, R.M.3
  • 4
    • 0036062556 scopus 로고    scopus 로고
    • Benzo(a)pyrene exposure induces CYP1A1 activity and expression in human endometrial cells
    • Bao, H., Vepakomma, M., and Sarkar, M. A., Benzo(a)pyrene exposure induces CYP1A1 activity and expression in human endometrial cells. J. Steroid Biochem. Mol. Biol., 81, 37-45 (2002).
    • (2002) J. Steroid Biochem. Mol. Biol. , vol.81 , pp. 37-45
    • Bao, H.1    Vepakomma, M.2    Sarkar, M.A.3
  • 5
    • 0034660185 scopus 로고    scopus 로고
    • Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress
    • Clark, J. E., Foresti, R., Green, C. J., and Motterlini, R., Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress. Biochem. J., 348 Pt 3, 615-619 (2000).
    • (2000) Biochem. J. , vol.348 , Issue.3 PART , pp. 615-619
    • Clark, J.E.1    Foresti, R.2    Green, C.J.3    Motterlini, R.4
  • 6
    • 0035135601 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo
    • Dertinger, S. D., Nazarenko, D. A., Silverstone, A. E., and Gasiewicz, T. A., Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo. Carcinogenesis, 22, 171-177 (2001).
    • (2001) Carcinogenesis , vol.22 , pp. 171-177
    • Dertinger, S.D.1    Nazarenko, D.A.2    Silverstone, A.E.3    Gasiewicz, T.A.4
  • 7
    • 0036709597 scopus 로고    scopus 로고
    • Cellular glutathione and thiols metabolism
    • Dickinson, D. A. and Forman, H. J., Cellular glutathione and thiols metabolism. Biochem. Pharmacol., 64, 1019-1026 (2002).
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1019-1026
    • Dickinson, D.A.1    Forman, H.J.2
  • 8
    • 0036710563 scopus 로고    scopus 로고
    • Cell signalling and the glutathione redox system
    • Filomeni, G., Rotilio, G., and Ciriolo, M. R., Cell signalling and the glutathione redox system. Biochem. Pharmacol., 64, 1057-1064 (2002).
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1057-1064
    • Filomeni, G.1    Rotilio, G.2    Ciriolo, M.R.3
  • 9
    • 0032874845 scopus 로고    scopus 로고
    • Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
    • Hayes, J. D. and McLellan, L. I., Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic. Res., 31, 273-300 (1999).
    • (1999) Free Radic. Res. , vol.31 , pp. 273-300
    • Hayes, J.D.1    McLellan, L.I.2
  • 10
    • 0033594963 scopus 로고    scopus 로고
    • Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
    • Jakobsson, P. J., Thoren, S., Morgenstern, R., and Samuelsson, B., Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. U.S.A., 96, 7220-7225 (1999).
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 7220-7225
    • Jakobsson, P.J.1    Thoren, S.2    Morgenstern, R.3    Samuelsson, B.4
  • 11
    • 0017640084 scopus 로고
    • Effects of linoleic acid hydroperoxide on the hepatic monooxygenase systems of microsomes from untreated, phenobarbital-treated, and 3-methylcholanthrene-treated rats
    • Jeffery, E., Kotake, A., and Azhary, R. E., Effects of linoleic acid hydroperoxide on the hepatic monooxygenase systems of microsomes from untreated, phenobarbital-treated, and 3-methylcholanthrene-treated rats. Mol. Pharmacol., 13, 415-425 (1977).
    • (1977) Mol. Pharmacol. , vol.13 , pp. 415-425
    • Jeffery, E.1    Kotake, A.2    Azhary, R.E.3
  • 12
    • 0033606107 scopus 로고    scopus 로고
    • Suppressive effects of alpha-Hederin on 2,3,7,8-tetrachlorodibenzo-p- dioxin-mediated murine Cyp1a-1 expression in the mouse hepatoma Hepa1c1c7 cells
    • Jeong, H. G. and Lee, S. S., Suppressive effects of alpha-Hederin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated murine Cyp1a-1 expression in the mouse hepatoma Hepa1c1c7 cells. Cancer Lett., 138, 131-137 (1999).
    • (1999) Cancer Lett. , vol.138 , pp. 131-137
    • Jeong, H.G.1    Lee, S.S.2
  • 13
    • 0028296451 scopus 로고
    • Exogenous glutathione attenuates the antiproliferative effect of buthionine sulfoximine
    • Kang, Y. J., Exogenous glutathione attenuates the antiproliferative effect of buthionine sulfoximine. Toxicology, 88, 177-189 (1994).
    • (1994) Toxicology , vol.88 , pp. 177-189
    • Kang, Y.J.1
  • 14
    • 0028099510 scopus 로고
    • Hydrogen peroxide-mediated inactivation of microsomal cytochrome P450 during monooxygenase reactions
    • Karuzina, I. I. and Archakov, A. I., Hydrogen peroxide-mediated inactivation of microsomal cytochrome P450 during monooxygenase reactions. Free Radic. Biol. Med., 17, 557-567 (1994).
    • (1994) Free Radic. Biol. Med. , vol.17 , pp. 557-567
    • Karuzina, I.I.1    Archakov, A.I.2
  • 15
    • 0024497521 scopus 로고
    • Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite
    • Keyse, S. M. and Tyrrell, R. M., Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. U.S.A., 86, 99-103 (1989).
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , pp. 99-103
    • Keyse, S.M.1    Tyrrell, R.M.2
  • 16
    • 0031966674 scopus 로고    scopus 로고
    • Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2
    • Kim, K. H., Lee, Y. S., Jung, I. S., Park, S. Y., Chung, H. Y., Lee, I. R., and Yun, Y. S., Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2. Planta Med., 64, 110-115 (1998).
    • (1998) Planta Med. , vol.64 , pp. 110-115
    • Kim, K.H.1    Lee, Y.S.2    Jung, I.S.3    Park, S.Y.4    Chung, H.Y.5    Lee, I.R.6    Yun, Y.S.7
  • 17
    • 0042977425 scopus 로고    scopus 로고
    • Activity of Cassia auriculata leaf extract in rats with alcoholic liver injury
    • Kumar Rajagopal, S., Manickam, P., Periyasamy, V., and Namasivayam, N., Activity of Cassia auriculata leaf extract in rats with alcoholic liver injury. J. Nutr. Biochem., 14, 452-458 (2003).
    • (2003) J. Nutr. Biochem. , vol.14 , pp. 452-458
    • Kumar Rajagopal, S.1    Manickam, P.2    Periyasamy, V.3    Namasivayam, N.4
  • 18
    • 0031057118 scopus 로고    scopus 로고
    • Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsan isolated from Panax ginseng
    • Lee, Y. S., Chung, I. S., Lee, I. R., Kim, K. H., Hong, W. S., and Yun, Y. S., Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsan isolated from Panax ginseng. Anticancer Res., 17, 323-331 (1997).
    • (1997) Anticancer Res. , vol.17 , pp. 323-331
    • Lee, Y.S.1    Chung, I.S.2    Lee, I.R.3    Kim, K.H.4    Hong, W.S.5    Yun, Y.S.6
  • 20
    • 0036665069 scopus 로고    scopus 로고
    • Anti-septicaemic effect of polysaccharide from Panax ginseng by macrophage activation
    • Lim, D. S., Bae, K. G., Jung, I. S., Kim, C. H., Yun, Y. S., and Song, J. Y., Anti-septicaemic effect of polysaccharide from Panax ginseng by macrophage activation. J. Infect., 45, 32-38 (2002).
    • (2002) J. Infect. , vol.45 , pp. 32-38
    • Lim, D.S.1    Bae, K.G.2    Jung, I.S.3    Kim, C.H.4    Yun, Y.S.5    Song, J.Y.6
  • 21
    • 0029093929 scopus 로고
    • Suppression of liver cytochrome P450 by alpha-hederin: Relevance to hepatoprotection
    • Liu, J., Liu, Y., Bullock, P., and Klaassen, C. D., Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection. Toxicol. Appl. Pharmacol., 134, 124-131 (1995).
    • (1995) Toxicol. Appl. Pharmacol. , vol.134 , pp. 124-131
    • Liu, J.1    Liu, Y.2    Bullock, P.3    Klaassen, C.D.4
  • 22
    • 0035430489 scopus 로고    scopus 로고
    • Reduced glutathione system: Role in cancer development, prevention and treatment
    • Locigno, R. and Castronovo, V., Reduced glutathione system: role in cancer development, prevention and treatment (review). Int. J. Oncol., 19, 221-236 (2001).
    • (2001) Int. J. Oncol. , vol.19 , pp. 221-236
    • Locigno, R.1    Castronovo, V.2
  • 23
    • 0017804861 scopus 로고
    • Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation
    • Maines, M. D. and Kappas, A., Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation. J. Biol. Chem., 253, 2321-2326 (1978).
    • (1978) J. Biol. Chem. , vol.253 , pp. 2321-2326
    • Maines, M.D.1    Kappas, A.2
  • 24
    • 0023731036 scopus 로고
    • Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications
    • Maines, M. D., Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J., 2, 2557-2268 (1988).
    • (1988) FASEB J. , vol.2 , pp. 2557-12268
    • Maines, M.D.1
  • 25
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: A regulator of second messenger gases
    • Maines, M. D., The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol., 37, 517-554 (1997).
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 517-554
    • Maines, M.D.1
  • 26
    • 0035024022 scopus 로고    scopus 로고
    • Thiols in cellular redox signalling and control
    • Moran, L. K., Gutteridge, J. M., and Quinlan, G. J., Thiols in cellular redox signalling and control. Curr. Med. Chem., 8, 763-772 (2001).
    • (2001) Curr. Med. Chem. , vol.8 , pp. 763-772
    • Moran, L.K.1    Gutteridge, J.M.2    Quinlan, G.J.3
  • 27
    • 0023061373 scopus 로고
    • P450 genes: Structure, evolution, and regulation
    • Nebert, D. W. and Gonzalez, F. J., P450 genes: structure, evolution, and regulation. Annu. Rev. Biochem., 56, 945-993 (1987).
    • (1987) Annu. Rev. Biochem. , vol.56 , pp. 945-993
    • Nebert, D.W.1    Gonzalez, F.J.2
  • 28
    • 0037068964 scopus 로고    scopus 로고
    • Clinical importance of the cytochromes P450
    • Nebert, D. W. and Russell, D. W., Clinical importance of the cytochromes P450. Lancet, 360, 1155-1162 (2002).
    • (2002) Lancet , vol.360 , pp. 1155-1162
    • Nebert, D.W.1    Russell, D.W.2
  • 30
    • 0043268709 scopus 로고    scopus 로고
    • Heme oxygenase-1: Unleashing the protective properties of heme
    • Otterbein, L. E., Soares, M. P., Yamashita, K., and Bach, F. H., Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol., 24, 449-455 (2003).
    • (2003) Trends Immunol. , vol.24 , pp. 449-455
    • Otterbein, L.E.1    Soares, M.P.2    Yamashita, K.3    Bach, F.H.4
  • 32
    • 0034190372 scopus 로고    scopus 로고
    • Regulation of redox glutathione levels and gene transcription in lung inflammation: Therapeutic approaches
    • Rahman, I. and MacNee, W., Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radic. Biol. Med., 28, 1405-1420 (2000).
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 1405-1420
    • Rahman, I.1    MacNee, W.2
  • 33
    • 0033989634 scopus 로고    scopus 로고
    • Hepatic drug metabolism and immunostimulation
    • Renton, K. W., Hepatic drug metabolism and immunostimulation. Toxicology, 142, 173-178 (2000).
    • (2000) Toxicology , vol.142 , pp. 173-178
    • Renton, K.W.1
  • 34
    • 0033648666 scopus 로고    scopus 로고
    • Heme oxygenase activity. Current methods and applications
    • Ryter, S. W., Kvam, E., and Tyrrell, R. M., Heme oxygenase activity. Current methods and applications. Methods Mol. Biol., 99, 369-391 (2000).
    • (2000) Methods Mol. Biol. , vol.99 , pp. 369-391
    • Ryter, S.W.1    Kvam, E.2    Tyrrell, R.M.3
  • 35
    • 0033973712 scopus 로고    scopus 로고
    • The heme synthesis and degradation pathways: Role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties
    • Ryter, S. W. and Tyrrell, R. M., The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic. Biol. Med., 28, 289-309 (2000).
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 289-309
    • Ryter, S.W.1    Tyrrell, R.M.2
  • 36
    • 0038740798 scopus 로고    scopus 로고
    • Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans
    • Ryu, S. D. and Chung, W. G., Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans. Food Chem. Toxicol., 41, 861-866 (2003).
    • (2003) Food Chem. Toxicol. , vol.41 , pp. 861-866
    • Ryu, S.D.1    Chung, W.G.2
  • 37
    • 0028492940 scopus 로고
    • Effects of furazolidone on duration of righting reflex loss induced with hexobarbital and zoxazolamine in the rat
    • Sasaki, N., Effects of furazolidone on duration of righting reflex loss induced with hexobarbital and zoxazolamine in the rat. J. Vet. Med. Sci., 56, 667-670 (1994).
    • (1994) J. Vet. Med. Sci. , vol.56 , pp. 667-670
    • Sasaki, N.1
  • 38
    • 0015579498 scopus 로고
    • A simplified method for the quantitative assay of small amounts of protein in biologic material
    • Schacterle, G. R. and Pollack, R. L., A simplified method for the quantitative assay of small amounts of protein in biologic material. Anal. Biochem., 51, 654-655 (1973).
    • (1973) Anal. Biochem. , vol.51 , pp. 654-655
    • Schacterle, G.R.1    Pollack, R.L.2
  • 40
    • 0034976320 scopus 로고    scopus 로고
    • Induction of cytochromes P450
    • Schuetz, E. G., Induction of cytochromes P450. Curr. Drug Metab., 2, 139-147 (2001).
    • (2001) Curr. Drug Metab. , vol.2 , pp. 139-147
    • Schuetz, E.G.1
  • 41
    • 0014428865 scopus 로고
    • Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
    • Sedlak, J. and Lindsay, R. H., Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem., 25, 192-205 (1968).
    • (1968) Anal. Biochem. , vol.25 , pp. 192-205
    • Sedlak, J.1    Lindsay, R.H.2
  • 42
    • 0019961923 scopus 로고
    • Changes of glutathione and protein bound SH-groups concentration in rat adrenals under acute and repeated stress
    • Sedlak, J. and Hanus, L., Changes of glutathione and protein bound SH-groups concentration in rat adrenals under acute and repeated stress. Endocrinol. Exp., 16, 103-109 (1982).
    • (1982) Endocrinol. Exp. , vol.16 , pp. 103-109
    • Sedlak, J.1    Hanus, L.2
  • 43
    • 0036250653 scopus 로고    scopus 로고
    • Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57BI/6 mouse in a tissue (kidney) selective manner
    • Seubert, J. M., Webb, C. D., and Bend, J. R., Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57BI/6 mouse in a tissue (kidney) selective manner. J. Biochem. Mol. Toxicol., 16, 96-106 (2002).
    • (2002) J. Biochem. Mol. Toxicol. , vol.16 , pp. 96-106
    • Seubert, J.M.1    Webb, C.D.2    Bend, J.R.3
  • 44
    • 0036385569 scopus 로고    scopus 로고
    • Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function
    • Shin, J. Y., Song, J. Y., Yun, Y. S., Yang, H. O., Rhee, D. K., and Pyo, S., Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function. Immunopharmacol. Immunotoxicol., 24, 469-482 (2002).
    • (2002) Immunopharmacol. Immunotoxicol. , vol.24 , pp. 469-482
    • Shin, J.Y.1    Song, J.Y.2    Yun, Y.S.3    Yang, H.O.4    Rhee, D.K.5    Pyo, S.6
  • 46
    • 0036310091 scopus 로고    scopus 로고
    • Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan
    • Song, J. Y., Han, S. K., Son, E. H., Pyo, S. N., Yun, Y. S., and Yi, S. Y., Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan. Int. Immunopharmacol., 2, 857-865 (2002).
    • (2002) Int. Immunopharmacol. , vol.2 , pp. 857-865
    • Song, J.Y.1    Han, S.K.2    Son, E.H.3    Pyo, S.N.4    Yun, Y.S.5    Yi, S.Y.6
  • 47
    • 0024596172 scopus 로고
    • The human 32-kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase
    • Taketani, S., Kohno, H., Yoshinaga, T., and Tokunaga, R., The human 32-kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase. FEBS Lett., 245, 173-176 (1989).
    • (1989) FEBS Lett. , vol.245 , pp. 173-176
    • Taketani, S.1    Kohno, H.2    Yoshinaga, T.3    Tokunaga, R.4
  • 48
    • 0035018226 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo
    • Thapliyal, R. and Maru, G. B., Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food Chem. Toxicol., 39, 541-547 (2001).
    • (2001) Food Chem. Toxicol. , vol.39 , pp. 541-547
    • Thapliyal, R.1    Maru, G.B.2
  • 49
    • 0035976810 scopus 로고    scopus 로고
    • Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa
    • Ueng, Y. F., Wang, J. J., Lin, L. C., Park, S. S., and Chen, C. F., Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa. Life Sci., 70, 207-217 (2001).
    • (2001) Life Sci. , vol.70 , pp. 207-217
    • Ueng, Y.F.1    Wang, J.J.2    Lin, L.C.3    Park, S.S.4    Chen, C.F.5
  • 50
    • 0038772403 scopus 로고    scopus 로고
    • Diterpene quinone tanshinone NA selectively inhibits mouse and human cytochrome p4501A2
    • Ueng, Y. F., Kuo, Y. H., Peng, H. C., Chen, T. L., Jan, W. C., Peter Guengerich, F., and Lin, Y. L., Diterpene quinone tanshinone NA selectively inhibits mouse and human cytochrome p4501A2. Xenobiotica, 33, 603-613 (2003).
    • (2003) Xenobiotica , vol.33 , pp. 603-613
    • Ueng, Y.F.1    Kuo, Y.H.2    Peng, H.C.3    Chen, T.L.4    Jan, W.C.5    Peter Guengerich, F.6    Lin, Y.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.