Effect of freeze-drying process conditions on the stability of nanoparticles

Drying Technology

Volumn 22, Issue 1-2, 2004, Pages 335-346

  Choi, M J ^a   Briancon S ^a   Andrieu, J ^a   Min, S G ^b   Fessi, H ^a  

^a UNIVERSITÉ LYON 1   (France)

^b Konkuk University   (South Korea)

Author keywords

Emulsion diffusion method; Freeze drying; Freezing; Nanoparticles

Indexed keywords

DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION; DRYING; EMULSIFICATION; FREEZING; SCANNING ELECTRON MICROSCOPY; SYNTHESIS (CHEMICAL); THERMODYNAMIC PROPERTIES;

FREEZE DRYING PROCESS; FREEZING RATE; POLYCAPROLACTONE (PCL);

NANOSTRUCTURED MATERIALS;

DIFFUSION; EMULSION; FREEZE DRYING; NANOPARTICLE;

EID: 16544376534     PISSN: 07373937     EISSN: None     Source Type: Journal    
DOI: 10.1081/DRT-120028238     Document Type: Article

References (11)

1. Allémann, E.; Gury, R.; Doelker, E.; Skinner, F.S.; Schutz, H. Distribution, kinetics and elimination of radioactivity after intravenous and intramuscular injection of C-savoxepine loaded poly(D,L-lactic acid) nanoparticles to rats. Journal of Controlled Release 1994, 29, 97-104.
2. De Chasteigner, S.; Fessi, H.; Cavé, G.; Devissaguet, J.P.; Puisieux, F. Gastro-intestinal tolerance study of a freeze-dried oral dosage form of indomethacin-loaded nanocapsules. S.T.P. Pharma Science 5 1995, 3, 242-246.
3. De Chasteigner, S.; Cavé, G.; Fessi, H.; Devissaguet, J.P.; Puisieux, F. Freeze-drying of itraconazole-loaded nanosphere suspensions: a feasibility study. Drug Development Research 1996, 38, 116-124.
4. Quintanar-Guerrero, D.; Ganem-quintanat, A.; Allémann, E.; Fessi, H.; Doelker, E. Influence of the stabilizer coating layer on the purification and freeze-drying of poly(D,L-lactic acid) nanoparticles prepared by an emulsion-diffusion technique. Journal Microencapsulation 1998, 15 (1), 107-119.
5. Crowe, L.M.; Reid, D.S.; Crowe, J.H. Is trehalose special for preserving dry materials? Biophys. J. 1996, 71, 2087-2093.
6. Tanaka, K.; Yakeda, T.; Fuji, K.; Miyajima, K. Cryoprotective mechanism of saccharides on freeze-drying of liposomes. Chem. Pharm. Bull. 1992, 40, 1-5.
7. Talsma, H.; Van Steenbergen, M.J.; Salemink, P.J.M.; Crommelin, D.J.A. The cryopreservation of liposomes. 1. A different scanning calorimetry study of the thermal behaviour of a liposome dispersion containing mannitol during freezing/thawing. Pharma. Res. 1991, 8, 1021-1026.
8. Schwarz, C.; Mehnert, W. Freeze-drying of drug-free and drug-loaded solid lipid nanoparticles (SLN). International Journal of Pharmaceutics 1997, 157, 171-179.
9. Saez, A.; Guzman, M.; Molpeceres, J.; Aberturas, M.R. Freeze-drying of polycaprolactone and poly(D,L-lactic-glycolic) nanoparticles induce minor particles size changes affecting the oral pharmacokinetics of loaded drugs. European Journal of Pharmaceutics and Biopharmaceutics 2000, 50, 379-387.
10. Ghio, S.; Barresi, A.A.; Rovero, G. About evaporative freezing and freeze-drying of fruits and vegetables. Food Bioproducts Proc., Trans I. Chem. E. C. 2000.
11. Choi, Mi-jung. Etude expérimentale, caractérisation, optimisation de la lyophilisation de particules submicroniques. Thèse UCB Lyon 2003. to be published.