TAK-778 enhances osteoblast differentiation of human bone marrow cells via an estrogen-receptor-dependent pathway

Journal of Cellular Biochemistry

Volumn 91, Issue 4, 2004, Pages 749-755

  Rosa, A L ^a   Beloti, M M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cell culture; Cellular differentiation; Drug therapy; Estrogen receptor; Osteogenesis

Indexed keywords

ALKALINE PHOSPHATASE; CHROMONE DERIVATIVE; ESTROGEN RECEPTOR; IPRIFLAVONE; N(4 DIETHOXYPHOSPHORYLMETHYLPHENYL) 1,2,4,5 TETRAHYDRO 4 METHYL 7,8 METHYLENEDIOXY 5 OXO 3 BENZOTHIEPIN 2 CARBOXAMIDE; TAK 778; TAMOXIFEN; UNCLASSIFIED DRUG; BENZOTHIEPIN DERIVATIVE; PROTEIN;

ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL COUNT; CELL CULTURE; CELL DENSITY; CELL DIFFERENTIATION; CELL FUNCTION; CELL VIABILITY; OSTEOBLAST; PRIORITY JOURNAL; CELL DIVISION; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; HUMAN; MALE; METABOLISM; SIGNAL TRANSDUCTION;

BENZOTHIEPINS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; HUMANS; MALE; OSTEOBLASTS; OSTEOGENESIS; PROTEINS; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TAMOXIFEN;

EID: 16544371971     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.10773     Document Type: Article

References (21)

1. Anderson JJB, Anthony M, Messina M, Garner SC. 1999. Effects of phyto-oestrogen on tissues. Nutr Res Rev 12:75-116.
2. Arts J, Kuiper GGJM, Janssen JMMF, Gustafsoon JÅ Lowik CWGM, Pols HAP, Van Leeuwen JPTM. 1997. Differential expression of estrogen receptors α and β during differentiation of human osteoblasts SV-HFO cells. Endocrinology 38:5067-5070.
3. Bord S, Horner A, Beavan S, Compston J. 2001. Estrogen receptors α and β are differentially expressed in developing human bone. J Clin Endocrinol Metab 86: 2309-2314.
4. Chen XW, Garner SC, Anderson JJB. 2002. Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway. Biochem Biophys Res Commun 295:417-422.
5. Fournier B, Häring S, Kaye AM, Sömjen D. 1996. Stimulation of creatinine kinase specific activity in human osteoblast and endometrial cells by estrogens and anti-estrogens and its modulation by calciotropic hormones. J Endocrinology 150:275-285.
6. Heerdt AS, Borgen PI. 1999. Current status of tamoxifen use: An update for the surgical oncologist. J Surg Oncol 72:42-49.
7. Hoshino T, Muranishi H, Saito K, Notoya K, Makino H, Nagai H, Sohda T, Ogawa Y. 2000. Enhancement of fracture repair in rats with streptozotocin- induced diabetes by a single injection of biodegradable microcapsules containing a bone formation stimulant, TAK-778. J Biomed Mater Res 51:299-306.
8. Hoshino T, Saito K, Muranishi H, Sohda T, Ogawa Y. 2001. Sustained-release microcapsules of a bone formation stimulant, TAK-778, for local injection into a fracture site. J Pharm Sci 90:2121-2130.
9. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. 1996. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930.
10. Lincks J, Boyan BD, Blachard CR, Lohmann CH, Liu Y, Cochran DL, Dean DD, Schwartz Z. 1998. Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition. Biomaterials 19:2219-2232.
11. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
12. Notoya K, Yoshida K, Tsukuda R, Taketomi S. 1994. Effect of ipriflavone on expression of markers characteristic of the osteoblast phenotype in rat bone marrow stromal cell culture. J Bone Miner Res 9:395-400.
13. Notoya K, Oda T, Gotoh M, Hoshino T, Muranishi H, Taketomi S, Sohda T, Makino H. 1999. Enhancement of osteogenesis in vitro and in vivo by a novel osteoblast differentiation promoting compound, TAK-778. J Pharmacol Exp Ther 290:1054-1064.
14. Oda TO, Notoya K, Gotoh M, Taketomi S, Fujisawa Y, Makino H, Sohda T. 1999. Synthesis of novel 2-benzothiopyran and 3-benzothiepin derivatives and their stimulatory effect on bone formation. J Med Chem 42: 751-760.
15. Owen TA, Aronow M, Shalhoub V, Barone LM, Wilming L, Tassinari MS, Kennedy MB, Pockwinse S, Lian JB, Stein GS. 1999. Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 143:357-370.
16. Perizzolo D, Lacefield WR, Brunette DM. 2001. Interaction between topography and coating in the formation of bone nodules in culture for hydroxyapatite- and titanium-coated micromachined surfaces. J Biomed Mater Res 56: 494-503.
17. Petilli M, Fiorelli G, Benvenuti S, Frediani U, Gori F, Brandi ML. 1995. Interactions between ipriflavone and the estrogen receptor. Calcif Tissue Int 56:160-165.
18. Qu Q, Härkönen PL, Väänänen HK. 1999. Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture. J Cell Biochem 73:500-507.
19. Rosa AL, Beloti MM. 2003a. TAK-778 enhances osteoblast differentiation of human bone marrow cells. J Cell Biochem 89:1148-1153.
20. Rosa AL, Beloti MM. 2003b. TAK-778 enhances osteoblast differentiation of human bone marrow cells cultured on titanium. Biomaterials 24:2927-2932.
21. Schwartz Z, Sylvia VL, Guinee T, Dean DD, Boyan BD. 2002. Tamoxifen elicits its anti-estrogen effects in growth plate chondrocytes by inhibiting protein kinase C. J Steroid Biochem Mol Biol 80:401-410.