Loop domain peptides from the SOS ras-guanine nucleotide exchange protein, identified from molecular dynamics calculations, strongly inhibit ras signaling

Protein Journal

Volumn 23, Issue 3, 2004, Pages 229-234

  Chie, Lyndon ^a,b   Friedman, Fred K ^c   Duncan, Thomas ^d   Chen, James M ^e   Chung, Denise ^b   Pincus, Matthew ^a,f  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b LONG ISLAND UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^e GILEAD SCIENCES   (United States)

^f SUNY Downstate Medical Center   (United States)

Author keywords

Effector domain; Insulin; Oncogenic ras; Oocyte maturation; P21; SOS loop peptides; SOS protein

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; INSULIN; PROTEIN P21; RAS PROTEIN; SOS PROTEIN; PEPTIDE FRAGMENT;

ARTICLE; CALCULATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; MOLECULAR DYNAMICS; NONHUMAN; ONCOGENE RAS; OOCYTE MATURATION; PEPTIDE SYNTHESIS; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGY; CHEMISTRY; FEMALE; METABOLISM; OOCYTE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; XENOPUS;

ANIMALS; COMPUTATIONAL BIOLOGY; FEMALE; OOCYTES; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RAS PROTEINS; SIGNAL TRANSDUCTION; SON OF SEVENLESS PROTEINS; XENOPUS;

EID: 16544391873     PISSN: 15723887     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JOPC.0000026418.82786.5e     Document Type: Article

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