Selective inhibition of oncogenic ras-p21 in vivo by agents that block its interaction with jun-N-kinase (JNK) and jun proteins Implications for the design of selective chemotherapeutic agents

Cancer Chemotherapy and Pharmacology

Volumn 41, Issue 1, 1997, Pages 79-85

  Amar, Shazia ^a,b,c   Glozman, Albert ^a,b,c   Chung, Denise ^c   Adler, Victor ^a,b,d,h   Ronai, Zeev ^d,h   Friedman, Fred K ^e   Robinson, Richard ^e   Brandt Rauf, Paul ^f   Yamaizumi, Z ^g   Pincus, Matthew R ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c LONG ISLAND UNIVERSITY   (United States)

^d AMERICAN HEALTH FOUNDATION   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f Columbia Coll of Phys and Surgeons ^*  (United States)

^g NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^h MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Jun proteins; Jun N kinase; Oncogenic ras p21; Selective inhibition

Indexed keywords

ANTINEOPLASTIC AGENT; INHIBITOR PROTEIN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PROGESTERONE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN P21; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; ENZYME ACTIVATION; NONHUMAN; ONCOGENE RAS; OOCYTE MATURATION; PRIORITY JOURNAL; PROTEIN INTERACTION; XENOPUS LAEVIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; ESCHERICHIA COLI; GENE EXPRESSION; GENES, JUN; INSULIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; ONCOGENE PROTEIN P21(RAS); OOCYTES; PROTEIN BINDING; PROTEIN KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; VIRAL PROTEINS; XENOPUS LAEVIS;

EID: 6844252268     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050711     Document Type: Article

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