Synthesis of silicon traceless linker for solid-phase reaction

Archives of Pharmacal Research

Volumn 27, Issue 4, 2004, Pages 371-375

  Mun, Han Seo ^a   Jeong, Jin Hyun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Benzodiazepine; Combinatorial chemistry; Fischer indole synthesis; Phenothiazine; Silicon linker; Solid phase reaction; Solvation; Swelling; Traceless linker

Indexed keywords

CROSS LINKING REAGENT; SILICON;

ARTICLE; CHEMISTRY; METHODOLOGY; PHARMACEUTICS; SYNTHESIS;

CROSS-LINKING REAGENTS; SILICON; TECHNOLOGY, PHARMACEUTICAL;

EID: 16544369829     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02980075     Document Type: Article

References (10)

1. Armstrong, A., Brackenridge, I., Jackson, R. F. W., and Kirk, J. M., A new method for the preparation of tertiary butyl ethers and esters. Tetrahedron Lett., 29, 2483-2486 (1988).
2. Holmes, C. P. and Jones, D. G., reagents for combinatorial organic synthesis: development of a new o-nitrobenzyl photolabile linker for solid phase synthesis. J. Org. Chem., 60, 2318-2319 (1995).
3. Hone, N. D., Davies, S. G., Devereux, N. J., Taylor, S. L., and Baxter, A. D., A highly acid labile silicon linker for solid phase synthesis. Tetrahedron Lett., 39, 897-900 (1998).
4. Krchňák, M., Szabo, L., and Vágner, J., A solid phase traceless synthesis of quinoxalinones. Tetrahedron Lett., 41, 2835-2838 (2000).
5. Lee, Y. H. and Silverman, R. B., Efficient solid-phase synthesis of compounds containing phenylalanine and its derivatives via side-chain attachment to the polymer support. J. Am. Chem. Soc., 121, 8407-8408 (1999).
6. Morales, G. A., Corbett, J. W., and DeGrado, W. F., Solid-phase synthesis of benzopiperazinones. J. Org. Chem., 63, 1172-1177 (1998).
7. Moyer, M. P., Shiurba, J. F., and Rapoport, H., Metal-halogen exchange of bromoindoles. A route to substituted indoles. J. Org. Chem., 51, 5106-5110 (1986).
8. Ponnusamy, E., Fotadar, U., Spisni, A., and Fiat, D., A novel method for the rapid, non-aqueous t-butoxycarbonylation of some o-labeled amino acids and O-N.M.R. parameters of the products. Synthesis, 48-49 (1986).
9. Posner, G. H. and Switzer, C., Total synthesis of natural estrone and estradiol methyl ethers in extremely high enantiomeric purity via an asymmetric Michael addition to an unsaturated sulfoxide. J. Am. Chem. Soc., 108, 1239-1244 (1986).
10. Slade, R. M., Phillips, M. A., and Berger, J. G., Application of an almost traceless linker in the synthesis of 2-alkylthiobenzimidazole combinatorial libraries. Molecular Diversity, 4, 215-219 (1998).