Application of an almost traceless linker in the synthesis of 2- alkylthiobenzimidazole combinatorial libraries

Molecular Diversity

Volumn 4, Issue 4, 1998, Pages 215-219

  Slade, Rachel M ^a,b   Phillips, Margo A ^a   Berger, Joel G ^a  

^a SIDDCO   (United States)

^b NONE   (United States)

Author keywords

Alkylthiobenzimidazole; Combinatorial chemistry; Phosphonium resin; Solid phase synthesis; Traceless linker

Indexed keywords

AMINE; BENZIMIDAZOLE DERIVATIVE; BROMINE DERIVATIVE; RESIN; TRIPHENYLPHOSPHINE;

ALKYLATION; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CYCLIZATION; PRIORITY JOURNAL; REACTION ANALYSIS; REDUCTION; SYNTHESIS;

ALKANES; BENZIMIDAZOLES; COMBINATORIAL CHEMISTRY TECHNIQUES; NITROBENZENES; ORGANOPHOSPHORUS COMPOUNDS; SULFHYDRYL COMPOUNDS;

EID: 0032471289     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009696618386     Document Type: Article

References (7)

1. Hughes, I., Application of polymer-bound phosphonium salts as traceless supports for solid phase synthesis, Tetrahedron Lett., 37 (1996) 7595-7598.
2. (a) Phillips, G.B. and Wei, G.P., Solid phase synthesis of benzimidazoles, Tetrahedron Lett., 37 (1996) 4887-4890.
3. (b) Lee, J., Murray, W.V. and Rivero, R.A., Solid phase synthesis of 3,4-disubstituted-7-carbamoyl-1,2,3,4-tetrahydroquinoxalin-2-ones, J. Org. Chem., 62 (1997) 3874-3879.
4. (c) Wei, G.P. and Phillips, G.B., Solid phase synthesis of benzimidazolones, Tetrahedron Lett., 39 (1998) 179-182.
5. (d) Mayer, J.P., Lewis, G.S., McGee, C. and Bankaitis-Davis, D., Solid phase synthesis of benzimidazoles, Tetrahedron Lett., 39 (1998) 6655-6658.
6. Lee, J., Gauthier, D. and Rivero, R.A., Solid phase synthesis of 1-alkyl-2-alkylthio-5-carbamoylbenzimidazoles, Tetrahedron Lett., 39 (1998) 201-204.
7. NAr-based macrocyclization: An application to the synthesis of vancomycin family models, J. Org. Chem., 59 (1994) 5535-5542, and references therein.