The behavior of dihydropyrazine with DNA strand-breakage activity in vivo

Biological and Pharmaceutical Bulletin

Volumn 26, Issue 11, 2003, Pages 1523-1527

  Yamaguchi, Tadatoshi ^a   Nomura, Hajime ^a   Matsunaga, Kazuhisa ^b   Ito, Shigeru ^c   Takata, Jiro ^b   Karube, Yoshiharu ^b  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Aminosugar; Apoptosis; Biodistribution; Cell line; Dihydropyrazine; DNA strand breakage

Indexed keywords

2,3 DIHYDRO 5,6 DIMETHYLPYRAZINE C 14; AMINOSUGAR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PYRAZINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ADPRT PROTEIN, RAT; DNA; PARP1 PROTEIN, MOUSE; PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD; BRAIN RADIATION; CELL LINE; CELL VIABILITY; DNA STRAND BREAKAGE; HEART; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; RADIOACTIVITY; SALIVARY GLAND; SPINAL CORD; STOMACH; THYMUS; ANIMAL; CHEMISTRY; DNA DAMAGE; DRUG EFFECT; HELA CELL; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PHYSIOLOGY; RAT; TISSUE DISTRIBUTION;

ANIMALS; APOPTOSIS; CELL LINE; DNA; DNA DAMAGE; HELA CELLS; HUMANS; MICE; MICE, INBRED ICR; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PYRAZINES; RATS; TISSUE DISTRIBUTION;

EID: 16544366580     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.26.1523     Document Type: Article

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