Palliative care: A supportive adjunct to pediatric phase I clinical trials for anticancer agents?

Pediatrics

Volumn 114, Issue 3, 2004, Pages 852-855

  Ulrich, Connie M ^a,b,c   Grady, Christine ^c   Wendler, David ^c  

^a School of Nursing and Center for Bioethics   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; CANCER PALLIATIVE THERAPY; CANCER PATIENT; CHILDHOOD CANCER; CLINICAL TRIAL; DOSE RESPONSE; DRUG RESEARCH; DRUG TOLERABILITY; HUMAN; MEDICAL CARE; MEDICAL ETHICS; METHODOLOGY; NOTE; ONCOLOGY; PATIENT PARTICIPATION; PRIORITY JOURNAL; SUPPORT GROUP; ARTICLE; CHILD; ETHICS; NEOPLASM; PALLIATIVE THERAPY; PARENT; PATIENT SELECTION; PHASE 1 CLINICAL TRIAL; TERMINAL CARE;

ANTINEOPLASTIC AGENTS; CHILD; CLINICAL TRIALS, PHASE I; HUMANS; NEOPLASMS; PALLIATIVE CARE; PARENTS; PATIENT SELECTION; TERMINAL CARE;

EID: 16544365948     PISSN: 00314005     EISSN: 00314005     Source Type: Journal    
DOI: 10.1542/peds.2003-0913-L     Document Type: Note

References (22)

1. Shah S, Weitman S, Langevin A, Bernstein M, Furman W, Pratt C. Phase I therapy trials in children with cancer. J Pediatr Hematol Oncol. 1998;20:431-438
2. Aleska K, Koren G. Ethical issues in including pediatric cancer patients in drug development trials [review]. Paediatr Drugs. 2002;4:257-265
3. Smith M, Bernstein M, Bleyer W, et al. Conduct of phase I trials in children with cancer. J Clin Oncol. 1998;16:966-978
4. Pratt C. Pediatric clinical trials. Oncologist. 1996;1:169-172
5. Pratt C. The conduct of phase I-II clinical trials in children with cancer. Med Pediatr Oncol. 1991;19:304-309
6. Weitman S, Carlson L, Pratt C. New drug development for pediatric oncology. Invest New Drugs. 1996;14:1-10
7. Ratain M, Mick R, Schilsky R, Siegler M. Statistical and ethical issues in the design and conduct of phase I and phase II clinical trials of new anticancer agents. J Natl Cancer Inst. 1993;85:1637-1643
8. Ackerman T. Phase I pediatric oncology trials. J Pediatr Oncol Nurs. 1995;12:143-145
9. Agrawal M, Danis M. End-of-life care for terminally ill participants in clinical research. J Palliat Med. 2002;5:729-737
10. Doyle D, Hanks GWC, Macdonald N. Oxford Textbook of Palliative Medicine. Oxford, United Kingdom: Oxford University Press; 1993
11. Lipsett MB. On the nature and ethics of phase I clinical trials of cancer chemotherapy. JAMA. 1982;248:941-942
12. Emanuel E, Wendler D, Grady C. What makes research ethical? JAMA. 2000;283:2701-2711
13. Deatrick JA, Angst DB, Moore C. Parents' views of their children's participation in phase I oncology clinical trials. J Pediatr Oncol Nurs. 2002;19:114-121
14. Levetown M. Ethical aspects of pediatric palliative care. J Palliat Care. 1996;12:35-39
15. American Academy of Pediatrics, Committee on Bioethics and Committee on Hospital Care. Palliative care for children. Pediatrics. 2000;106:351-357
16. Hilden JM, Emanuel EJ, Fairclough DL, et al. Attitudes and practices among pediatric oncologists regarding end-of-life care: results of the 1998 American Society of Clinical Oncology Survey. J Clin Oncol. 2001;19:205-212
17. von Gunten CF, Ferris FD, Emanuel LL. The patient-physician relationship. Ensuring competency in end-of-life care: communication and relational skills. JAMA. 2000;284:3051-3057
18. Kapo J, Casarett D. Palliative care in phase I trials: an ethical obligation or undue inducement? J Palliat Med. 2002;5:661-665
19. Wolfe J, Grier H, Klar N, et al. Symptoms and suffering at the end of life in children with cancer. N Engl J Med. 2000;342:326-333
20. Wolfe J, Friebert S, Hilden J. Caring for children with advanced cancer: integrating palliative care. Pediatr Clin North Am. 2002;49:1043-1062
21. Nelson RM, Merz JF. Voluntariness of consent for research. Med Care. 2002;40:V69-V80
22. Grady C. Money for research participation: does it invalidate informed consent? Am J Bioeth. 2002;1:40-44