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Volumn 20, Issue 5, 1998, Pages 431-438

Phase I therapy trials in children with cancer

Author keywords

Pediatric oncology; Phase I trials

Indexed keywords

(3 IODOBENZYL)GUANIDINE I 131; 6 DIAZO 5 OXONORLEUCINE; ACIVICIN; AMSACRINE; ANCITABINE; ANTINEOPLASTIC AGENT; BETA INTERFERON; BISANTRENE; CARBOPLATIN; DEOXYTHIOGUANOSINE; DIAZIQUONE; ESORUBICIN; ETOPOSIDE; FAZARABINE; FLUDARABINE; FLUOROURACIL; IDARUBICIN; IFOSFAMIDE; INDICINE N OXIDE; INTERLEUKIN 2; IPROPLATIN; MITOFLAXONE; MITOXANTRONE; PACLITAXEL; PENTOSTATIN; RAZOXANE; RETINOIC ACID; TAU INTERFERON; UNINDEXED DRUG; ZINOSTATIN;

EID: 0032465981     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-199809000-00005     Document Type: Article
Times cited : (49)

References (65)
  • 1
    • 0031016857 scopus 로고    scopus 로고
    • Critical role of phase I clinical trials in cancer treatment
    • Ratain MJ, Collyar D, Kamen B, et al. Critical role of phase I clinical trials in cancer treatment. J Clin Oncol 1997;15:853-9.
    • (1997) J Clin Oncol , vol.15 , pp. 853-859
    • Ratain, M.J.1    Collyar, D.2    Kamen, B.3
  • 2
  • 3
    • 0018971138 scopus 로고
    • Phase I clinical and pharmacokinetic study of 4′(9-Acridinylamino)-methanesulfon-m-anisidide in children with cancer
    • Rivera G, Evans WE, Dahl GV, et al. Phase I clinical and pharmacokinetic study of 4′(9-Acridinylamino)-methanesulfon-m-anisidide in children with cancer. Cancer Res 1980;40:4250-3.
    • (1980) Cancer Res , vol.40 , pp. 4250-4253
    • Rivera, G.1    Evans, W.E.2    Dahl, G.V.3
  • 4
    • 0027081810 scopus 로고
    • Phase I and pharmacokinetic evaluation of All-Trans-Retinoic Acid in pediatric patients with cancer
    • Smith MA, Adamson PC, Balis FM, et al. Phase I and pharmacokinetic evaluation of All-Trans-Retinoic Acid in pediatric patients with cancer. J of Clin Oncol 1992;10:1666-73.
    • (1992) J of Clin Oncol , vol.10 , pp. 1666-1673
    • Smith, M.A.1    Adamson, P.C.2    Balis, F.M.3
  • 5
    • 0029553179 scopus 로고
    • A phase I study of acivicin in refractory pediatric solid tumors
    • Baruchel S, Bernstein M, Whitehead M, et al. A phase I study of acivicin in refractory pediatric solid tumors. Invest New Drugs 1995;13:211-6.
    • (1995) Invest New Drugs , vol.13 , pp. 211-216
    • Baruchel, S.1    Bernstein, M.2    Whitehead, M.3
  • 6
    • 0019857236 scopus 로고
    • Phase I study on 5-AZA-deoxycytidine in children with acute leukemia
    • Rivard GE, Momparler RL, Demers J, et al. Phase I study on 5-AZA-deoxycytidine in children with acute leukemia. Leuk Res 1981;5:453-62.
    • (1981) Leuk Res , vol.5 , pp. 453-462
    • Rivard, G.E.1    Momparler, R.L.2    Demers, J.3
  • 7
    • 0021346105 scopus 로고
    • Phase I study of aziridinyl-benzoquinone (AZQ, NSC 182986) in children with cancer
    • Tan CTC, Hancock CH, Mondora A, et al. Phase I study of aziridinyl-benzoquinone (AZQ, NSC 182986) in children with cancer. Cancer Res 1984;44:831-5.
    • (1984) Cancer Res , vol.44 , pp. 831-835
    • Tan, C.T.C.1    Hancock, C.H.2    Mondora, A.3
  • 8
    • 0022523336 scopus 로고
    • Phase I clinical and pharmacokinetic study of bisantrene in refractory pediatric solid tumors
    • Pratt CB, Sinkule JA, Etcubanas E, et al. Phase I clinical and pharmacokinetic study of bisantrene in refractory pediatric solid tumors. Invest New Drugs 1986;4:149-53.
    • (1986) Invest New Drugs , vol.4 , pp. 149-153
    • Pratt, C.B.1    Sinkule, J.A.2    Etcubanas, E.3
  • 9
    • 0022493977 scopus 로고
    • Phase I study of carboplatin (CBDCA) in children with cancer
    • Bacha DM, Caparros-Sison B, Allen JA, et al. Phase I study of carboplatin (CBDCA) in children with cancer. Cancer Treat Rep 1986;70:865-9.
    • (1986) Cancer Treat Rep , vol.70 , pp. 865-869
    • Bacha, D.M.1    Caparros-Sison, B.2    Allen, J.A.3
  • 10
    • 0023521414 scopus 로고
    • Pediatric phase I trial of carboplatin: A Childrens Cancer Study Group report
    • Gaynon PS, Ettinger LJ, Moel D, et al. Pediatric phase I trial of carboplatin: a Childrens Cancer Study Group report. Cancer Treat Rep 1987;71:1039-42.
    • (1987) Cancer Treat Rep , vol.71 , pp. 1039-1042
    • Gaynon, P.S.1    Ettinger, L.J.2    Moel, D.3
  • 11
    • 0027200804 scopus 로고
    • A phase I study of carboplatin in children with acute leukemia in bone marrow relapse
    • Ettinger LJ, Krailo MD, Gaynon PS, et al. A phase I study of carboplatin in children with acute leukemia in bone marrow relapse. Cancer 1993;72: 917-22.
    • (1993) Cancer , vol.72 , pp. 917-922
    • Ettinger, L.J.1    Krailo, M.D.2    Gaynon, P.S.3
  • 12
    • 0026100242 scopus 로고
    • A phase 1 clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia
    • Santana VM, Mirro, Jr. J, Harwood FC, et al. A phase 1 clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia. J Clin Oncol 1991;9:416-22.
    • (1991) J Clin Oncol , vol.9 , pp. 416-422
    • Santana, V.M.1    Mirro J., Jr.2    Harwood, F.C.3
  • 13
    • 0018595292 scopus 로고
    • Evaluation of cyclocytidine in children with advanced acute leukemia and solid tumors
    • Finklestein JZ, Higgins G, Krivit W, et al. Evaluation of cyclocytidine in children with advanced acute leukemia and solid tumors. Cancer Treat Rep 1979;63:1331-3.
    • (1979) Cancer Treat Rep , vol.63 , pp. 1331-1333
    • Finklestein, J.Z.1    Higgins, G.2    Krivit, W.3
  • 14
    • 0019467252 scopus 로고
    • Phase I study of 2′-deoxycoformycin in acute lymphoblastic leukemia
    • Poplack DG, Sallan SE, Rivera G, et al. Phase I study of 2′-deoxycoformycin in acute lymphoblastic leukemia. Cancer Res 1981;41:3343-6.
    • (1981) Cancer Res , vol.41 , pp. 3343-3346
    • Poplack, D.G.1    Sallan, S.E.2    Rivera, G.3
  • 15
    • 0024316286 scopus 로고
    • Phase I study of 4′-deoxydoxorubicin (esorubicin) in children with malignant solid tumors
    • Pratt CB, Douglass EC, Meyer WH, et al. Phase I study of 4′-deoxydoxorubicin (esorubicin) in children with malignant solid tumors. Invest New Drugs 1989;7:209-11.
    • (1989) Invest New Drugs , vol.7 , pp. 209-211
    • Pratt, C.B.1    Douglass, E.C.2    Meyer, W.H.3
  • 16
    • 0021827603 scopus 로고
    • Phase I evaluation of β-2′-deoxythioguanosine in pediatric patients with leukemia
    • Higgins GR, Jamin DC, Shore NA, et al. Phase I evaluation of β-2′-deoxythioguanosine in pediatric patients with leukemia. Cancer Treat Rep 1985;69:699-701.
    • (1985) Cancer Treat Rep , vol.69 , pp. 699-701
    • Higgins, G.R.1    Jamin, D.C.2    Shore, N.A.3
  • 17
    • 0021867679 scopus 로고
    • Phase 1 clinical evaluation of diaziquone in childhood cancer
    • Ettinger LJ, Siegel SE, Belasco JB, et al. Phase 1 clinical evaluation of diaziquone in childhood cancer. Cancer Treat Rep 1985;69:323-7.
    • (1985) Cancer Treat Rep , vol.69 , pp. 323-327
    • Ettinger, L.J.1    Siegel, S.E.2    Belasco, J.B.3
  • 18
    • 0025279037 scopus 로고
    • Phase I evaluation of diaziquone in childhood cancer
    • Falletta JM, Gushing B, Lauer S, et al. Phase I evaluation of diaziquone in childhood cancer. Invest New Drugs 1990;8:167-70.
    • (1990) Invest New Drugs , vol.8 , pp. 167-170
    • Falletta, J.M.1    Gushing, B.2    Lauer, S.3
  • 19
    • 0023856453 scopus 로고
    • Pharmacokinetic and phase I study of intravenous DON (6-diazo-5-oxo-L-norleucine) in children
    • Sullivan MP, Nelson JA, Feldman S, et al. Pharmacokinetic and phase I study of intravenous DON (6-diazo-5-oxo-L-norleucine) in children. Cancer Chemother Pharmacol 1988;21:78-84.
    • (1988) Cancer Chemother Pharmacol , vol.21 , pp. 78-84
    • Sullivan, M.P.1    Nelson, J.A.2    Feldman, S.3
  • 20
    • 0028176596 scopus 로고
    • Phase I study of oral etoposide in children with refractory solid tumors
    • Mathew P, Ribeiro RC, Sonnichsen D, et al. Phase I study of oral etoposide in children with refractory solid tumors. J Clin Oncol 1994;12:1452-7.
    • (1994) J Clin Oncol , vol.12 , pp. 1452-1457
    • Mathew, P.1    Ribeiro, R.C.2    Sonnichsen, D.3
  • 21
    • 0027740033 scopus 로고
    • A phase I trial of fazarabine in refractory pediatric solid tumors: A Pediatric Oncology Group study
    • Bernstein ML, Whitehead VM, Grier H, et al. A phase I trial of fazarabine in refractory pediatric solid tumors: a Pediatric Oncology Group study. Invest New Drugs 1993;11:309-12.
    • (1993) Invest New Drugs , vol.11 , pp. 309-312
    • Bernstein, M.L.1    Whitehead, V.M.2    Grier, H.3
  • 22
    • 0024443913 scopus 로고
    • Phase I trial and pharmacokinetic evaluation of fazarabine in children
    • Heideman RL, Gillespie A, Ford H, et al. Phase I trial and pharmacokinetic evaluation of fazarabine in children. Cancer Res 1989;49:5213-6.
    • (1989) Cancer Res , vol.49 , pp. 5213-5216
    • Heideman, R.L.1    Gillespie, A.2    Ford, H.3
  • 23
    • 0025789733 scopus 로고
    • Phase I study of flavone acetic acid (NSC 347512, LM975) in patients with pediatric malignant solid tumors
    • Pratt CB, Relling MV, Meyer WH, et al. Phase I study of flavone acetic acid (NSC 347512, LM975) in patients with pediatric malignant solid tumors. Am J Clin Oncol 1991;14:483-6.
    • (1991) Am J Clin Oncol , vol.14 , pp. 483-486
    • Pratt, C.B.1    Relling, M.V.2    Meyer, W.H.3
  • 24
    • 0025221247 scopus 로고
    • Pharmacology of fludarabine phosphate after a phase I/II trial by a loading bolus and continuous infusion in pediatric patients
    • Avramis VI, Champagne J, Sato J, et al. Pharmacology of fludarabine phosphate after a phase I/II trial by a loading bolus and continuous infusion in pediatric patients. Cancer Res 1990;50:7226-31.
    • (1990) Cancer Res , vol.50 , pp. 7226-7231
    • Avramis, V.I.1    Champagne, J.2    Sato, J.3
  • 25
    • 0025287674 scopus 로고
    • Phase I study of a 120-hour continuous intravenous infusion of 5-fluorouracil in pediatric patients with recurrent solid tumors: A Pediatric Oncology Group study
    • Green DM, Krischer JP, Bell B, et al. Phase I study of a 120-hour continuous intravenous infusion of 5-fluorouracil in pediatric patients with recurrent solid tumors: A Pediatric Oncology Group study. Med Pediatr Oncol 1990;18:321-4.
    • (1990) Med Pediatr Oncol , vol.18 , pp. 321-324
    • Green, D.M.1    Krischer, J.P.2    Bell, B.3
  • 26
    • 0023461335 scopus 로고
    • Phase I trial of homoharringtonine in children with refractory leukemia
    • Tan CTC, Luks E, Bacha DM et al. Phase I trial of homoharringtonine in children with refractory leukemia. Cancer Treat Rep 1987;71:1245-8.
    • (1987) Cancer Treat Rep , vol.71 , pp. 1245-1248
    • Tan, C.T.C.1    Luks, E.2    Bacha, D.M.3
  • 27
    • 0022507449 scopus 로고
    • Phase I study of ICRF-187 in pediatric cancer patients and comparison of its pharmacokinetics in children and adults
    • Holcenberg JS, Tutsch KD, Earhart RH, et al. Phase I study of ICRF-187 in pediatric cancer patients and comparison of its pharmacokinetics in children and adults. Cancer Treat Rep 1986;70:703-9.
    • (1986) Cancer Treat Rep , vol.70 , pp. 703-709
    • Holcenberg, J.S.1    Tutsch, K.D.2    Earhart, R.H.3
  • 28
    • 0023278663 scopus 로고
    • Phase I and clinical pharmacological study of 4-demethoxydaunorubicin (idarubicin) in children with advanced cancer
    • Tan CTC, Hancock, Steinherz P, et al. Phase I and clinical pharmacological study of 4-demethoxydaunorubicin (idarubicin) in children with advanced cancer. Cancer Res 1987;47:2990-5.
    • (1987) Cancer Res , vol.47 , pp. 2990-2995
    • Tan, C.T.C.1    Hancock2    Steinherz, P.3
  • 29
    • 0023750607 scopus 로고
    • Phase I clinical trial of orally administered 4-demethoxydaunorubicin (idarubicin) with pharmacokinetic and in vitro drug sensitivity testing in children with refractory leukemia
    • Pui C-H, de Graaf SSN, Dow LW, et al. Phase I clinical trial of orally administered 4-demethoxydaunorubicin (idarubicin) with pharmacokinetic and in vitro drug sensitivity testing in children with refractory leukemia. Cancer Res 1988;48:5348-52.
    • (1988) Cancer Res , vol.48 , pp. 5348-5352
    • Pui, C.-H.1    De Graaf, S.S.N.2    Dow, L.W.3
  • 30
    • 0027180881 scopus 로고
    • A phase I study of ifosfamide with mesna given daily for 3 consecutive days to children with malignant solid tumors
    • Pratt CB, Meyer WH, Douglass EC, et al. A phase I study of ifosfamide with mesna given daily for 3 consecutive days to children with malignant solid tumors. Cancer 1993;71:3661-5.
    • (1993) Cancer , vol.71 , pp. 3661-3665
    • Pratt, C.B.1    Meyer, W.H.2    Douglass, E.C.3
  • 31
    • 0027233725 scopus 로고
    • A phase I study of ifosfamidc given on alternate days to treat children with brain tumors
    • Pratt CB, Douglass EC, Kovnar EH, et al. A phase I study of ifosfamidc given on alternate days to treat children with brain tumors. Cancer 1993;71:3666-9.
    • (1993) Cancer , vol.71 , pp. 3666-3669
    • Pratt, C.B.1    Douglass, E.C.2    Kovnar, E.H.3
  • 32
    • 0025164637 scopus 로고
    • Phase I trial of indicine-N-oxide in children with leukemia and solid tumors: A Pediatric Oncology Group study
    • Whitehead VM, Bernstein ML, Vega R, et al. Phase I trial of indicine-N-oxide in children with leukemia and solid tumors: a Pediatric Oncology Group study. Cancer Chemother Pharmacol 1990;26:377-9.
    • (1990) Cancer Chemother Pharmacol , vol.26 , pp. 377-379
    • Whitehead, V.M.1    Bernstein, M.L.2    Vega, R.3
  • 33
    • 0025897346 scopus 로고
    • Recombinant interferon beta: A phase I/II trial in children with recurrent brain tumors
    • Allen J, Packer R, Bleyer A, et al. Recombinant interferon beta: A phase I/II trial in children with recurrent brain tumors. J Clin Oncol 1991;9:783-8.
    • (1991) J Clin Oncol , vol.9 , pp. 783-788
    • Allen, J.1    Packer, R.2    Bleyer, A.3
  • 34
    • 0026563941 scopus 로고
    • Phase I study of recombinant human interferon gamma in children with relapsed acute leukemia
    • Mahmoud HH, Pui C-H, Kennedy W, et al. Phase I study of recombinant human interferon gamma in children with relapsed acute leukemia. Leukemia 1992;6:1181-4.
    • (1992) Leukemia , vol.6 , pp. 1181-1184
    • Mahmoud, H.H.1    Pui, C.-H.2    Kennedy, W.3
  • 35
    • 0026649305 scopus 로고
    • A phase I study of interleukin-2 in children with cancer
    • Roper M, Smith MA, Sondel PM, et al. A phase I study of interleukin-2 in children with cancer. Am J Pediatr Hematol Oncol 1992;14:305-11.
    • (1992) Am J Pediatr Hematol Oncol , vol.14 , pp. 305-311
    • Roper, M.1    Smith, M.A.2    Sondel, P.M.3
  • 36
    • 0024394993 scopus 로고
    • A phase I study of interleukin-2 in children with cancer and evaluation of clinical and immunologic status during therapy: A Pediatric Oncology Group study
    • Nasr S, McKolanis J, Pais R, et al. A phase I study of interleukin-2 in children with cancer and evaluation of clinical and immunologic status during therapy: A Pediatric Oncology Group study. Cancer 1989;64:783-8.
    • (1989) Cancer , vol.64 , pp. 783-788
    • Nasr, S.1    McKolanis, J.2    Pais, R.3
  • 37
    • 0026736580 scopus 로고
    • Phase I study of recombinant human interleukein-2 for pediatric malignancies: Feasibility of outpatient therapy. A Pediatric Oncology Group Study
    • Pais RC, Abdel-Mageed A, Ghim TT, et al. Phase I study of recombinant human interleukein-2 for pediatric malignancies: feasibility of outpatient therapy. A Pediatric Oncology Group Study. J Immunother 1992;12:138-46.
    • (1992) J Immunother , vol.12 , pp. 138-146
    • Pais, R.C.1    Abdel-Mageed, A.2    Ghim, T.T.3
  • 38
    • 0027093713 scopus 로고
    • Phase I/II study of iodine 131 metaiodobenzylguanidine in chemoresistant neuroblastoma: A United Kingdom Children's Cancer Study Group investigation
    • Lashford LS, Lewis IJ, Fielding SK, et al. Phase I/II study of iodine 131 metaiodobenzylguanidine in chemoresistant neuroblastoma: a United Kingdom Children's Cancer Study Group investigation. J Clin Oncol 1992;10:1889-96.
    • (1992) J Clin Oncol , vol.10 , pp. 1889-1896
    • Lashford, L.S.1    Lewis, I.J.2    Fielding, S.K.3
  • 39
    • 0023130855 scopus 로고
    • Phase I study of iproplatin in pediatric patients: A Pediatric Group Study
    • Pratt CB, Kamen BA, Winick N, et al. Phase I study of iproplatin in pediatric patients: a Pediatric Group Study. Cancer Treat Rep 1987;71:87-8.
    • (1987) Cancer Treat Rep , vol.71 , pp. 87-88
    • Pratt, C.B.1    Kamen, B.A.2    Winick, N.3
  • 41
    • 0021887929 scopus 로고
    • Mitoxantrone in refractory acute leukemia in children: A phase I study
    • Starling KA, Mulne AF, Vats TS, et al. Mitoxantrone in refractory acute leukemia in children: a phase I study. Invest New Drugs 1985;3:191-5.
    • (1985) Invest New Drugs , vol.3 , pp. 191-195
    • Starling, K.A.1    Mulne, A.F.2    Vats, T.S.3
  • 42
    • 0018215462 scopus 로고
    • Phase I study of neocarzinostatin in children with cancer
    • Rivera G, Howarth C, Aur RJA, et al. Phase I study of neocarzinostatin in children with cancer. Cancer Treat Rep 1978;62:2105-7.
    • (1978) Cancer Treat Rep , vol.62 , pp. 2105-2107
    • Rivera, G.1    Howarth, C.2    Aur, R.J.A.3
  • 43
    • 85061023349 scopus 로고
    • Phase I trial of N-methylformamide in pediatric patients with refractory leukemia
    • Murphy SB, Mirro J, Pui C-H, et al. Phase I trial of N-methylformamide in pediatric patients with refractory leukemia. Cancer Treat Rep 1987;12:1229-30.
    • (1987) Cancer Treat Rep , vol.12 , pp. 1229-1230
    • Murphy, S.B.1    Mirro, J.2    Pui, C.-H.3
  • 44
    • 0027332874 scopus 로고
    • Phase I trial of paclitaxel in children with refractory solid tumors: A Pediatric Oncology Group study
    • Hurwitz CA, Relling MV, Weitman SD, et al. Phase I trial of paclitaxel in children with refractory solid tumors: A Pediatric Oncology Group study. J Clin Oncol 1993;11:2324-9.
    • (1993) J Clin Oncol , vol.11 , pp. 2324-2329
    • Hurwitz, C.A.1    Relling, M.V.2    Weitman, S.D.3
  • 45
    • 0026517786 scopus 로고
    • Pediatric phase I trial, pharmacokinetic study, and limited sampling strategy for piritrexim administered on a low-dose, intermittent schedule
    • Adamson PC, Balis FM, Miser J, et al. Pediatric phase I trial, pharmacokinetic study, and limited sampling strategy for piritrexim administered on a low-dose, intermittent schedule. Cancer Res 1992;52:521-4.
    • (1992) Cancer Res , vol.52 , pp. 521-524
    • Adamson, P.C.1    Balis, F.M.2    Miser, J.3
  • 46
    • 0025337302 scopus 로고
    • Pediatric phase I trial and pharmacokinetic study of piritrexim administered orally on a five-day schedule
    • Adamson PC, Balis FM, Miser J, et al. Pediatric phase I trial and pharmacokinetic study of piritrexim administered orally on a five-day schedule. Cancer Res 1990;50:4464-7.
    • (1990) Cancer Res , vol.50 , pp. 4464-4467
    • Adamson, P.C.1    Balis, F.M.2    Miser, J.3
  • 47
    • 0023199546 scopus 로고
    • Phase I trial of procarbazine as a 5-day continuous infusion in children with central nervous system tumors
    • Van Eys J, Cangir A, Pack R, et al. Phase I trial of procarbazine as a 5-day continuous infusion in children with central nervous system tumors. Cancer Treat Rep 1987;71:973-4.
    • (1987) Cancer Treat Rep , vol.71 , pp. 973-974
    • Van Eys, J.1    Cangir, A.2    Pack, R.3
  • 48
    • 0019495535 scopus 로고
    • Phase I trial of rubidazone (NSC 164011) in children with cancer
    • Tan CTC, Mitta SK, Steinherz L, et al. Phase I trial of rubidazone (NSC 164011) in children with cancer. Med Ped Oncol 1981;9:347-53.
    • (1981) Med Ped Oncol , vol.9 , pp. 347-353
    • Tan, C.T.C.1    Mitta, S.K.2    Steinherz, L.3
  • 49
    • 0023881861 scopus 로고
    • A pediatric phase I and pharmacokinetic study of spirohydantoin mustard
    • Heideman RL, Kelley JA, Packer RJ, et al. A pediatric phase I and pharmacokinetic study of spirohydantoin mustard. Cancer Res 1988;48:2292-5.
    • (1988) Cancer Res , vol.48 , pp. 2292-2295
    • Heideman, R.L.1    Kelley, J.A.2    Packer, R.J.3
  • 50
    • 0029101271 scopus 로고
    • A phase I study of sulofenur in refractory pediatric malignant solid tumors
    • Pratt CB, Bowman LC, Marina N, et al. A phase I study of sulofenur in refractory pediatric malignant solid tumors. Invest New Drugs 1995;13:63-6.
    • (1995) Invest New Drugs , vol.13 , pp. 63-66
    • Pratt, C.B.1    Bowman, L.C.2    Marina, N.3
  • 51
    • 0024499359 scopus 로고
    • Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: Evidence for dose-dependent plasma clearance of thiotepa
    • Heideman RL, Cole DE, Balis F, et al. Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: evidence for dose-dependent plasma clearance of thiotepa. Cancer Res 1989;49:736-41.
    • (1989) Cancer Res , vol.49 , pp. 736-741
    • Heideman, R.L.1    Cole, D.E.2    Balis, F.3
  • 52
    • 0022403035 scopus 로고
    • Pediatric phase I trial and pharmacokinetic study of tiazofurin (NSC 286193)
    • Balis FM, Lange BJ, Packer RJ, et al. Pediatric phase I trial and pharmacokinetic study of tiazofurin (NSC 286193). Cancer Res 1985;45:5169-72.
    • (1985) Cancer Res , vol.45 , pp. 5169-5172
    • Balis, F.M.1    Lange, B.J.2    Packer, R.J.3
  • 53
    • 0027407637 scopus 로고
    • Pediatric phase I trial and pharmacokinetic study of topotecan administered as a 24-hour continuous infusion
    • Blaney SM, Balis FM, Cole DE, et al. Pediatric phase I trial and pharmacokinetic study of topotecan administered as a 24-hour continuous infusion. Cancer Res 1993;53:1032-6.
    • (1993) Cancer Res , vol.53 , pp. 1032-1036
    • Blaney, S.M.1    Balis, F.M.2    Cole, D.E.3
  • 54
    • 0028357993 scopus 로고
    • Phase I study of topotecan for pediatric patients with malignant solid tumors
    • Pratt CB, Stewart C, Santana VM, et al. Phase I study of topotecan for pediatric patients with malignant solid tumors. J Clin Oncol 1994;12:539-43.
    • (1994) J Clin Oncol , vol.12 , pp. 539-543
    • Pratt, C.B.1    Stewart, C.2    Santana, V.M.3
  • 55
    • 0023200411 scopus 로고
    • Pediatric phase I trial and pharmacokinetic study of trimetrexate
    • Balis FM, Patel R, Luks E, et al. Pediatric phase I trial and pharmacokinetic study of trimetrexate. Cancer Res 1987;47:4973-6.
    • (1987) Cancer Res , vol.47 , pp. 4973-4976
    • Balis, F.M.1    Patel, R.2    Luks, E.3
  • 56
    • 0027461778 scopus 로고
    • Phase I trial of trimetrexate in pediatric solid tumors: A Pediatric Oncology Group study
    • Pappo AS, Vats T, Williams TE, et al. Phase I trial of trimetrexate in pediatric solid tumors: A Pediatric Oncology Group study. Med Ped Oncol 1993;21:280-2.
    • (1993) Med Ped Oncol , vol.21 , pp. 280-282
    • Pappo, A.S.1    Vats, T.2    Williams, T.E.3
  • 57
    • 0027331526 scopus 로고
    • Phase I clinical trial of recombinant human tumor necrosis factor in children with refractory solid tumors: A Pediatric Oncology Group study
    • Furman WL, Strother D, McClain K, et al. Phase I clinical trial of recombinant human tumor necrosis factor in children with refractory solid tumors: A Pediatric Oncology Group study. J Clin Oncol 1993;11:2205-10.
    • (1993) J Clin Oncol , vol.11 , pp. 2205-2210
    • Furman, W.L.1    Strother, D.2    McClain, K.3
  • 58
    • 0019170358 scopus 로고
    • Phase I evaluation of vindesine in children: A Southwest Oncology Group Pilot Study
    • Komp D, Vats T, Shepherd DA, et al. Phase I evaluation of vindesine in children: a Southwest Oncology Group Pilot Study. Med Fed Oncol 1980;8:243-50.
    • (1980) Med Fed Oncol , vol.8 , pp. 243-250
    • Komp, D.1    Vats, T.2    Shepherd, D.A.3
  • 59
    • 0025924266 scopus 로고
    • Response rates, duration of response, and dose response effects in phase I studies of antineoplastics
    • Von Hoff DD, Turner J, Response rates, duration of response, and dose response effects in phase I studies of antineoplastics. Invest New Drugs 1991;9:115-22.
    • (1991) Invest New Drugs , vol.9 , pp. 115-122
    • Von Hoff, D.D.1    Turner, J.2
  • 60
    • 0025353690 scopus 로고
    • Responses and toxic deaths in phase I clinical trials
    • Decoster G, Stein G, Holdener EE, Responses and toxic deaths in phase I clinical trials. Ann Oncol 1990;1:175-81.
    • (1990) Ann Oncol , vol.1 , pp. 175-181
    • Decoster, G.1    Stein, G.2    Holdener, E.E.3
  • 61
    • 0022542911 scopus 로고
    • Therapeutic response in phase I trials of antineoplastic agents
    • Estey E, Hoth D, Simon R, et al. Therapeutic response in phase I trials of antineoplastic agents. Cancer Treat Rep 1986;70:1105-15.
    • (1986) Cancer Treat Rep , vol.70 , pp. 1105-1115
    • Estey, E.1    Hoth, D.2    Simon, R.3
  • 62
    • 0030920199 scopus 로고    scopus 로고
    • Pediatric phase II cancer chemotherapy trials: A Pediatric Oncology Group study
    • Weitman S, Ochoa S, Sullivan J, et al. Pediatric phase II cancer chemotherapy trials: a Pediatric Oncology Group study. J Pediatr Hematol Oncol 1997;19:187-91.
    • (1997) J Pediatr Hematol Oncol , vol.19 , pp. 187-191
    • Weitman, S.1    Ochoa, S.2    Sullivan, J.3
  • 63
    • 0027524863 scopus 로고
    • Statistical and ethical issues in the design and conduct of phase I and II clinical trials of new anticancer agents
    • Ratain MJ, Mick R, Schilsky R, et al. Statistical and ethical issues in the design and conduct of phase I and II clinical trials of new anticancer agents. J Natl Cancer Inst 1993;85:1637-43.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1637-1643
    • Ratain, M.J.1    Mick, R.2    Schilsky, R.3
  • 64
    • 0029793053 scopus 로고    scopus 로고
    • Workshop on phase I study design
    • Arbuck SG. Workshop on phase I study design. Ann Oncol 1996;7:567-73.
    • (1996) Ann Oncol , vol.7 , pp. 567-573
    • Arbuck, S.G.1
  • 65
    • 0023757107 scopus 로고
    • Clinical trials in pediatric oncology
    • Leventhal BG and Graham ML. Clinical trials in pediatric oncology. Semin Oncol 1988;15:482-7.
    • (1988) Semin Oncol , vol.15 , pp. 482-487
    • Leventhal, B.G.1    Graham, M.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.