Oxygen transport and cell viability in an annular flow bioreactor: Comparison of laminar couette and Taylor-vortex flow regimes

Biotechnology and Bioengineering

Volumn 89, Issue 7, 2005, Pages 766-774

  Curran, Stephen J ^a   Black, Richard A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Bioreactor; Cell culture; Hydrodynamics; Scale up; Tissue engineering; Transport processes

Indexed keywords

BIOREACTORS; CELLS; CORRELATION METHODS; DATA REDUCTION; FLUID DYNAMICS; LAMINAR FLOW; MASS TRANSFER; REYNOLDS NUMBER; SHEAR STRESS; TISSUE; TURBULENCE; VORTEX FLOW;

CELL VIABILITY; LAMINAR COUETTE FLOW; OXYGEN TRANSPORT; TAYLOR VORTEX FLOWS;

OXYGEN;

DISSOLVED OXYGEN; OXYGEN;

AERATION; ANIMAL CELL; ANNULAR FLOW BIOREACTOR; ARTICLE; BIOREACTOR; CALCULATION; CELL CULTURE; CELL STRAIN L 929; CELL SUSPENSION; CELL VIABILITY; CORRELATION ANALYSIS; FIBER OPTICS; FIBROBLAST; HYDRODYNAMICS; INTERMETHOD COMPARISON; LAMINAR COUETTE FLOW; LAMINAR FLOW; MEASUREMENT; MECHANICAL PROBE; MOUSE; NONHUMAN; OXYGEN TRANSPORT; SCALE UP; SHEAR STRESS; TAYLOR VORTEX FLOW; TIME; TISSUE ENGINEERING; TURBULENT FLOW; VORTEX MOTION;

AEROBIOSIS; ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; FIBROBLASTS; L CELLS (CELL LINE); MICE; OXYGEN; RHEOLOGY; SHEAR STRENGTH; WATER MOVEMENTS;

EID: 16444371783     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20361     Document Type: Article

References (37)

1. Andereck CD, Liu SS, Swinney HL. 1986. Flow regimes in a circular Couette flow system with independently rotating cylinders. J Fluid Mech 164:155-183.
2. Born C, Zhang Z, Al-Rubeai M, Thomas CR. 1992. Estimation of disruption of animal cells by laminar shear stress. Biotechnol Bioeng 40:1004-1010.
3. Botchwey EA, Pollack SR, El-Amin S, Levine EM, Tuan RS, Laurencin CT. 2003. Human osteoblast-like cells in three-dimensional culture with fluid flow. Biorheology 40:299-306.
4. Campero RJ, Vigil RD. 1997. Axial dispersion during low Reynolds number Taylor-Couette flow: intra vortex mixing effects. Chem Eng Sci 52:3303-3310.
5. Cherry RS, Papoutsakis ET. 1986. Hydrodynamic effects on cells in tissue culture bioreactors. Bioproc Eng 1:29-41.
6. Chisti Y, Moo-Young M. 1987. Airlift reactors: characteristics, applications and design considerations. Chem Eng Commun 60:1195-1242.
7. Cole JA. 1976. Taylor-vortex instability and annulus length effects. J Fluid Mech 75:1-15.
8. Cote P, Bersillon JL, Huyard A. 1989. Bubble free aeration using membranes. Mass transfer analysis. J Membr Sci 47:91-106.
9. Croughan MS, Sayre ES, Wang DIC. 1989. Viscous reduction of turbulent damage in animal cell culture. Biotech Bioeng 33:862-872.
10. Curran SJ. 2002. Hydrodynamics and mass transport in an annular-flow bioreactor. PhD thesis. Liverpool, UK: University of Liverpool.
11. Curran SJ, Black RA. 2004. Quantitative experimental study of shear stresses and mixing in progressive flow regimes within annular-flow bioreactors. Chem Eng Sci 59:5859-5868.
12. Ducommun P, Ruffieux P-A, Furter M-P, Marison I, von Stockar U. 2000. A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures. J Biotechnol 78:139-147.
13. Frisch SM, Francis H. 1994. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 4:619-626.
14. Fuchs JR, Pomerantseva I, Ochoa ER, Vacanti JP, Fauza DO. 2003. Fetal tissue engineering: In vitro analysis of muscle constructs. J Pediatr Surg 38:1348-1353.
15. Garcia-Briones M, Chalmers JJ. 1992. Cell-bubble interactions, mechanisms of suspended cell damage. Ann NY Acad Sci 665:219-229.
16. Grifoll J, Farriol X, Cirait F. 1986. Mass transfer at smooth and rough surfaces in a circular Couette flow. Int J Heat Mass Transfer 29:1911-1918.
17. Hammond TG, Hammond JM. 2001. Optimised suspension culture: the rotating wall vessel. Am J Physiol Renal Physiol 281:F12-F25.
18. Handa-Corrigan A, Emery AN, Spier RE. 1989. Effect of gas-liquid interfaces on the growth of suspended animal cells. Mechanism of cell damage by bubbles. Enzyme Microb Technol 11:230-235.
19. Haut B, Amor HB, Coulon L, Jacquet A, Halloin V. 2003. Hydrodynamics and mass transfer in a Couette-Taylor bioreactor for the culture of animal cells. Chem Eng Sci 58:777-784.
20. Henzler H-J. 2000. Particle stress in bioreactors. In: Scheper TH, series editor. Influence of stress on cell growth and product formation. Advances in biochemical engineering/biotechnology, Vol. 67. Heidelberg: Springer-Verlag, p 35-82.
21. Hua J, Erickson LE, Yiin TY, Glasgow LA. 1993. A review of the effects of shear and interfacial phenomena on cell viability. Crit Rev Biotechnol 13:305-328.
22. Kataoka K, Takigawa T. 1981. Intermixing over cell boundary between Taylor vortices. AIChEJ 27:504-508.
23. Kellner K, Liebsch G, Klimant I, Wolfbeis OS, Blunk T, Schulz MB, Gobfriech A. 2002. Determination of oxygen gradients in engineered tissue using a fluorescent sensor. Biotechnol Bioeng 80:73-83.
24. Kreith F. 1998. The CRC handbook of mechanical engineering. Boca Raton, FL: CRC Press, 1998.
25. Kunas KT, Papoutsakis ET. 1990. Damage mechanisms of suspended animal cells in agitated bioreactors with and without bubble entrainment. Biotechnol Bioeng 36:476-483.
26. Legrand J, Coeuret F. 1986. Circumferential mixing in one-phase and two-phase Taylor vortex flows. Chem Eng Sci 41:47-53.
27. McGill G, Shimamura A, Bates RC, Savage RE, Fisher DE. 1997. Loss of matrix adhesion triggers rapid transformation-selective apoptosis in fibroblasts. J Cell Biol 138:910-911.
28. Obradovic B, Meldon JH, Freed LE, Vunjak-Novakovic G. 2000. Glycosaminoglycan deposition in engineered cartilage: experiments and mathematical model. AIChE J 46:1860-1871.
29. Park K, Donnelly RJ. 1980. Study of the transition to Taylor-vortex flow. Phys Rev A 24:2277-2279.
30. Resende MM, Tardioli PW, Fernandez VM, Ferreira ALO, Giordano RLC, Giordano RC. 2001. Distribution of suspended particles in a Taylor-Poiseuille vortex flow reactor. Chem Eng Sci 56:755-761.
31. Rucci N, Migliaccio S, Zani BM, Taranta A, Teti A. 2002. Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV). J Cell Biochem 85:167-179.
32. 2) oxygen uptake rates in animal cultures. J Biotechnol 63:85-95.
33. 2B. Biotech Bioeng 78:545-555.
34. Saini S, Wick TM. 2003. Concentric cylinder bioreactor for production of tissue engineered cartilage: effect of seeding density and hydrodynamic loading on construct development. Biotechnol Prog 19:510-521.
35. Taylor GI. 1923. Stability of a viscous liquid contained between two rotating cylinders. Proc R Soc Lond A 157:565-578.
36. Tramper J. 1995. Oxygen gradients in animal cell bioreactors. Cytotechnology 18:27-34.
37. Unsworth BR, Lelkes PI. 1998. Growing tissues in microgravity. Nat Med 4:901-907.