Reduction of perforin, granzyme B, and cytokine interferon γ by ethanol in male Fischer 344 rats

Alcoholism: Clinical and Experimental Research

Volumn 27, Issue 4, 2003, Pages 670-676

  Dokur, Madhavi ^b   Boyadjieva, Nadka I ^b   Sarkar, Dipak K ^a  

^a RUTGERS UNIVERSITY   (United States)

^b NONE

Author keywords

Cytolytic Activity; Gene Expression; Natural Killer Cells and Other Splenocytes

Indexed keywords

ALCOHOL; GAMMA INTERFERON; GRANZYME B; MESSENGER RNA; PERFORIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; CYTOLYSIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; NATURAL KILLER CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; REDUCTION; SPLEEN; SPLEEN CELL; WESTERN BLOTTING;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 1642582184     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.alc.0000060528.53113.5c     Document Type: Article

References (56)

1. Austin Taylor M, Bennett M, Kumar V, Schatzle JD (2000) Functional defects of NK cells treated with chloroquine mimic the lytic defects observed in perforin-deficient mice. J Immunol 165:5048-5053.
2. Blank SE, Pfister LJ, Gallucci RM, Meadows GG (1993) Ethanol-induced changes in peripheral blood and splenic natural killer cells. Alcohol Clin Exp Res 17:561-565.
3. Boyadjieva N, Dokur M, Advis JP, Meadows GG, Sarkar DK (2001) Chronic ethanol inhibits NK cell cytolytic activity: role of opioid peptide beta-endorphin. J Immunol 167:5645-5652.
4. Chadha KC, Whitney RB, Cummings MK, Norman M, Windle M, Stadler I (1990) Evaluation of interferon system among chronic alcoholics. Prog Clin Biol Res 325:123-133.
5. Chen GJ, Huang DS, Watzl B, Watson RR (1993) Ethanol modulation of tumor necrosis factor and gamma interferon production by murine splenocytes and macrophages. Life Sci 52:1319-1326.
6. Collier SD, Pruett SB (2000) Mechanisms of suppression of poly I:C-induced activation of NK cells by ethanol. Alcohol 21:87-95.
7. Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA (1993) Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 259:1739-1742.
8. Doherty PC (1993) Cell-mediated cytotoxicity. Cell 5:607-612.
9. Doll R, Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66:1191-1308.
10. Fehniger TA, Carson WE, Caligiuri MA (1999) Costimulation of human natural killer cells is required for interferon gamma production. Transplant Proc 31:1476-1478.
11. Feldman JG, Hazan M (1975) A case-control investigation of alcohol, tobacco, and diet in head and neck cancer. Prev Med 4:444-463.
12. Gardiner CM, Reen DJ (1998) Differential cytokine regulation of natural killer cell-mediated necrotic and apoptotic cytotoxicity. Immunology 93:511-517.
13. Garro AJ, Espina N, McBeth D, Wang SL, Wu-Wang CY (1992) Effects of alcohol consumption on DNA methylation reactions and gene expression: implications for increased cancer risk. Eur J Cancer Prev (Suppl 3) 1:19-23.
14. Garro AJ, Lieber CS (1990) Alcohol and cancer. Annu Rev Pharmacol Toxicol 30:219-249.
15. Gonzalez FM, Vargas JA, Lacoma F, Gea-Banacloche JC, Vergara J, Fernandez-Corugedo A, Durantez A (1993) Natural killer cell activity in laryngeal carcinoma. Arch Otolaryngol Head Neck Surg 119:69-72.
16. Hameed A, Lowrey DM, Lichtenheld M, Podack ER (1988) Characterization of three serine esterases isolated from human IL-2-activated killer cells. J Immunol 141:3142-3147.
17. Hanna N (1985) The role of natural killer cells in the control of tumor growth and metastasis. Biochim Biophys Acta 780:213-226.
18. Henney CS, Kuribayashi K, Kern DE, Gillis S (1981) Interleukin-2 augments natural killer cell activity. Nature 291:335-338.
19. Hudig D, Allison NJ, Pickett TM, Winkler U, Kam CM, Powers JC (1991) The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors. Immunology 147:1360-1368.
20. Hudig D, Gregg NJ, Kam CM, Powers JC (1987) Lymphocyte granule-mediated cytolysis requires serine protease activity. Biochem Biophys Res Commun 149:882-888.
21. Irwin MR (1993) Alcoholism and reduced natural killer cell activity: role of central CRF in neural control of immunity. Adv Biosci 86:69-78.
22. Jiang H, Yang X, Soriano RN, Fujimura T, Krishnan K, Kobayashi M (2000) Distinct patterns of cytokine gene suppression by the equivalent effective doses of cyclosporine and tacrolimus in rat heart allografts. Immunobiology 202:280-292.
23. Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olsen KJ, Podack ER, Zinkernagel RM, Hengartner H (1994) Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37.
24. Kagi D, Seiler P, Pavlovic J, Ledermann B, Burki K, Zinkernagel RM, Hengartner H (1995) The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur J Immunol 25:3256-3262.
25. Liu CC, Walsh CM, Young JD (1995) Perforin: structure and function. Immunol Today 16:194-201.
26. Mather GG, Talcott PA, Exon JH (1994) Characterization of a chemically induced tumor model and the effects of natural killer cell depletion by antiasialo GM-1. Immunobiology 190:333-345.
27. Orange JS, Biron CA (1996) Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J Immunol 156:4746-4756.
28. O'Shea JJ, Ortaldo JR (1990) Killer T's, macrophages, and NK's. The Fourth International Cell-Mediated Cytotoxicity Workshop, sponsored by the Pittsburgh Cancer Institute and the University of Pittsburgh Medical Health Care Division, Oglebay Park, WV, USA. New Biol 2:779-782.
29. Podack ER (1995) Execution and suicide: cytotoxic lymphocytes enforce Draconian laws through separate molecular pathways. Curr Opin Immunol 7:11-16.
30. Reiter Z (1993) Interferon - a major regulator of natural killer cell-mediated cytotoxicity. J Interferon Res 13:247-257.
31. Riccardi C, Giampietri A, Migliorati G, Cannarile L, D'Adamio L, Herberman RB (1986) Generation of mouse natural killer (NK) cell activity: effect of interleukin-2 (IL-2) and interferon (IFN) on the in vivo development of natural killer cells from bone marrow (BM) progenitor cells. Int J Cancer 38:553-562.
32. Rothman K, Keller A (1972) The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx. J Chronic Dis 25:711-716.
33. Salcedo TW, Azzoni L, Wolf SF, Perussia B (1993) Modulation of perforin and granzyme messenger RNA expression in human natural killer cells. J Immunol 151:2511-2520.
34. Sayers TJ, Mason LH, Pilaro A, Wiltrout TA, Komschlies K, Munger WL, Wiltrout RH (1993) Substrate-specific proteases (BLT-esterase) are localized predominantly in the natural killer cells of unprimed mice. J Leukoc Biol 53:454-461.
35. Schantz SP, Brown BW, Lira E, Taylor DL, Beddingfield N (1987) Evidence for the role of natural immunity in the control of metastatic spread of head and neck cancer. Cancer Immunol Immunother 25:141-148.
36. Seaman WE, Sleisenger M, Eriksson E, Koo GC (1987) Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity. J Immunol 138:4539-4544.
37. Shi L, Kam CM, Powers JC, Aebersold R, Greenberg AH (1992) Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J Exp Med 176:1521-1529.
38. Shresta S, MacIvor DM, Heusel JW, Russell JH, Ley TJ (1995) Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proc Natl Acad Sci USA 92:5679-5683.
39. Shresta S, Pham CT, Thomas DA, Graubert TA, Ley TJ (1998) How do cytotoxic lymphocytes kill their targets? Curr Opin Immunol 10:581-587.
40. Simon MM, Hausmann M, Tran T, Ebnet K, Tschopp J, Tha Hla R, Mullbacher A (1997) In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A × B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells. J Exp Med 186:1781-1786.
41. Spitzer JH, Meadows GG (1999) Modulation of perforin, granzyme A, and granzyme B in murine natural killer (NK), IL2 stimulated NK, and lymphokine-activated killer cells by alcohol consumption. Cell Immunol 194:205-212.
42. Street SE, Cretney E, Smyth MJ (2001) Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 97:192-197.
43. Szabo G, Mandrekar P, Dolganiuc A, Catalano D, Kodys K (2001) Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levels. Alcohol Clin Exp Res 25:1766-1772.
44. Trinchieri G (1991) Biology of natural killer cells, in Advances in Immunology (Dixon FJ ed), vol 47, pp 187-360. Academic Press, San Diego.
45. Tuyns AJ, Obradovic M (1975) Unexpected high incidence of primary liver cancer in Geneva, Switzerland. J Natl Cancer Inst 54:61-64.
46. Velotti F, Palmieri G, D'Ambrosio D, Piccoli M, Frati L, Santoni A (1992) Differential expression of granzyme A and granzyme B proteases and their secretion by fresh rat natural killer cells (NK) and lymphokine-activated killer cells with NK phenotype (LAK-NK). Eur J Immunol 22:1049-1053.
47. Watson RR (1988) Ethanol, immunomodulation and cancer. Prog Food Nutr Sci 12:189-209.
48. Watson RR, Borgs P, Witte M, McCuskey RS, Lantz C, Johnson MI, Mufti SI, Earnest DL (1994) Alcohol, immunomodulation, and disease. Alcohol Alcohol 29:131-139.
49. Williams RR, Horm JW (1977) Association of cancer sites with tobacco and alcohol consumption and socioeconomic status of patients: interview study from the Third National Cancer Survey. J Natl Cancer Inst 58:525-547.
50. Wiltrout RH, Herberman RB, Zhang SR, Chirigos MA, Ortaldo JR, Green KM Jr, Talmadge JE (1985) Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver. J Immunol 134:4267-4275.
51. Wu WJ, Pruett SB (1996a) Suppression of splenic natural killer cell activity in a mouse model for binge drinking. I. Direct effects of ethanol and its major metabolites are not primarily responsible for decreased natural killer cell activity. J Pharmacol Exp Ther 278:1325-1330.
52. Wu WJ, Pruett SB (1996b) Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system. J Pharmacol Exp Ther 278:1331-1339.
53. Wu WJ, Pruett SB (1997) Involvement of catecholamines and glucocorticoids in ethanol-induced suppression of splenic natural killer cell activity in a mouse model for binge drinking. Alcohol Clin Exp Res 21:1030-1036.
54. Wu WJ, Wolcott RM, Pruett SB (1994) Ethanol decreases the number and activity of splenic natural killer cells in a mouse model for binge drinking. J Pharmacol Exp Ther 271:722-729.
55. Wynder EL (1977) The dietary environment and cancer. J Am Diet Assoc 71:385-392.
56. Yirmiya R, Ben-Eliyahu S, Gale RP, Shavit Y, Liebeskind JC, Taylor AN (1992) Ethanol increases tumor progression in rats: possible involvement of natural killer cells. Brain Behav Immun 6:74-86.