Primary Central Nervous System Phaeohyphomycosis: A Review of 101 Cases

Clinical Infectious Diseases

Volumn 38, Issue 2, 2004, Pages 206-216

  Revankar, Sanjay G ^a,d   Sutton, Deanna A ^b   Rinaldi, Michael G ^b,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^d VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; FLUCYTOSINE; ITRACONAZOLE; VORICONAZOLE;

AGED; ANTIFUNGAL ACTIVITY; BRAIN SURGERY; CENTRAL NERVOUS SYSTEM INFECTION; CHILD; CLADOPHIALOPHORA BANTIANA; CONTROLLED STUDY; FEMALE; FUNGUS; FUNGUS CULTURE; FUNGUS ISOLATION; HUMAN; IMMUNE DEFICIENCY; IMMUNE STATUS; MAJOR CLINICAL STUDY; MALE; MIDDLE EAST; MORTALITY; NEWBORN; PATIENT; PHAEOHYPHOMYCOSIS; PRIORITY JOURNAL; RAMICHLORIDIUM MACKENZIEI; REVIEW; STANDARD; SURVIVAL RATE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMPHOTERICIN B; ANTIFUNGAL AGENTS; CENTRAL NERVOUS SYSTEM FUNGAL INFECTIONS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; ITRACONAZOLE; MALE; MIDDLE AGED; MYCOSES; RISK FACTORS; TREATMENT OUTCOME;

EID: 1642578876     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/380635     Document Type: Review

References (127)

1. Davis LE. Fungal infections of the central nervous system. Neurol Clin 1999; 17:761-81.
2. Go JL, Kim PE, Ahmadi J, et al. Fungal infections of the central nervous system. Neuroimaging Clin N Am 2000; 10:409-25.
3. Revankar SD, Patterson JE, Sutton DA, et al. Disseminated phaeohyphomycosis: review of an emerging mycosis. Clin Infect Dis 2002; 34:467-76.
4. Matsumoto T, Ajello L, Matsuda T, et al. Developments in hyalohyphomycosis and phaeohyphomycosis. J Med Vet Mycol 1994; 32 (Suppl 1):329-49.
5. Fader RC, McGinnis MR. Infections caused by dematiaceous fungi: chromoblastomycosis and phaeohyphomycosis. Infect Dis Clin North Am 1988; 2:925-38.
6. Rinaldi MG. Phaeohyphomycosis. Dermatol Clin 1996; 14:147-53.
7. Horre R, De Hoog GS. Primary cerebral infections by melanized fungi: a review. Stud Mycol 1999; 43:176-93.
8. Aldape KD, Fox HS, Roberts JP, et al. Cladosporium trichoides cerebral phaeohyphomycosis in a liver transplant recipient: report of a case. Am J Clin Pathol 1991; 95:499-502.
9. Banerjee U, Mohapatra AK, Sarkar C, et al. Cladosporiosis (cerebral phaeohyphomycosis) of brain - a case report. Mycopathologia 1989; 105:163-6.
10. Banerjee TK, Patwari AK, Dutta R, et al. Cladosporium bantianum meningitis in a neonate. Indian J Pediatr 2002; 69:721-3.
11. Bennett JE, Bonner H, Jennings AE, et al. Chronic meningitis caused by Cladosporium trichoides. Am J Clin Pathol 1973; 59:398-407.
12. Bhatia R, Tandon P, Misra NK. Inflammatory lesions of the basal ganglia and thalamus: review of twenty-one cases. Neurosurgery 1986; 19:983-8.
13. Binford CH, Thompson RK, Gorham ME, et al. Mycotic brain abscess due to Cladosporium trichoides, a new species. Am J Clin Pathol 1952; 22:535-42.
14. Brown JW III, Nadell J, Sanders CV, et al. Brain abscess caused by Cladosporium trichoides (bantianum): a case with paranasal sinus involvement. South Med J 1976; 69:1519-21.
15. Buxi TB, Prakash K, Vohra R, et al. Imaging in phaeohyphomycosis of the brain: case report. Neuroradiology 1996; 38:139-41.
16. Chandramukhi A, Ramadevi MG, Shankar SK. Cerebral cladosporiosis - a neuropathological and microbiological study. Clin Neurol Neurosurg 1983; 85:245-53.
17. Crichlow DK, Enrile FT, Memon MY. Cerebellar abscess due to Cladosporium trichoides (bantianum): case report. Am J Clin Pathol 1973; 60:416-21.
18. Dar L, Singh S, Banerjee U, et al. Brain abscess due to Xylohypha bantiana. Indian J Med Microbiol 1993; 11:148-50.
19. Dastur HM, Chaukar AP, Rebello MD. Cerebral chromoblastomycosis due to Cladosporium trichoides (bantianum). I. A review and case report. Neurol India 1966; 14:1-5.
20. Duque O. Meningo-encephalitis and brain abscess caused by Cladosporium and Fonsecaea. Am J Clin Pathol 1961; 36:505-17.
21. Emmens RK, Richardson D, Thomas W, et al. Necrotizing cerebritis in an allogeneic bone marrow transplant recipient due to Cladophialophora bantiana. J Clin Microbiol 1996; 34:1330-2.
22. Freitas A, Pedral-Sampaio DB, Espinheira NL, et al. Cladophialophora bantiana (previously Cladosporium trichoides): first report of a case in Brazil. Braz J Infect Dis 1997; 1:313-6.
23. Goel A, Satoskar A, Desai AP, et al. Brain abscess caused by Cladosporium trichoides. Br J Neurosurg 1992; 6:591-3.
24. Gupta SK, Manjunath-Prasad KS, Sharma BS, et al. Brain abscess in renal transplant recipients: report of three cases. Surg Neurol 1997; 48:284-7.
25. Heney C, Song E, Kellen A, et al. Cerebral phaeohyphomycosis caused by Xylohypha bantiana. Eur J Clin Microbiol Infect Dis 1989; 8:984-8.
26. Hironaga M, Watanabe S. Cerebral phaeohyphomycosis caused by Cladosporium bantianum: a case in a female who had cutaneous alternariosis in her childhood. Sabouraudia 1980; 18:229-35.
27. Imwidthaya P. Systemic fungal infections in Thailand. J Med Vet Mycol 1994; 32:395-9.
28. Keyser A, Schmid FX, Linde HJ, et al. Disseminated Cladophialophora bantiana infection in a heart transplant recipient. J Heart Lung Transplant 2002; 21:503-5.
29. Kim RC, Hodge CJ Jr, Lamberson HV Jr, et al. Traumatic intracerebral implantation of Cladosporium trichoides. Neurology 1981; 31:1145-8.
30. King AB, Collette TS. Brain abscess due to Cladosporium trichoides. Bull Johns Hop Hosp 1952; 91:298-305.
31. Lirng JF, Tien RD, Osumi AK, et al. Cerebral phaeohyphomycosis complicated with brain abscess: a case report. Zhonghua Yi Xue Za Zhi 1995; 55:491-5.
32. McGill HC, Brueck JW. Brain abscess due to Hormodendrum species. Arch Pathol 1956; 62:303-11.
33. Middleton FG, Jurgenson PF, Utz JP, et al. Brain abscess caused by Cladosporium trichoides. Arch Intern Med 1976; 136:444-8.
34. Mukherji SK, Castillo M. Cerebral phaeohyphomycosis caused by Xylohypha bantiana: MR findings. AJR Am J Roentgenol 1995; 164:1304-5.
35. Nadkarni TD, Goel A, Shenoy A, et al. Cladosporium bantianum (trichoides) infection of the brain. J Postgrad Med 1993; 39:43-4.
36. Palaoglu S, Sav A, Basak T, et al. Cerebral phaeohyphomycosis. Neurosurgery 1993; 33:894-7.
37. Riley O, Mann SH. Brain abscess caused by Cladosporium trichoides. Am J Clin Pathol 1960; 33:525-31.
38. Rossmann SN, Cernoch PL, Davis JR. Dematiaceous fungi are an increasing cause of human disease. Clin Infect Dis 1996; 22:73-80.
39. Salama AD, Rogers T, Lord GM, et al. Multiple Cladosporium brain abscesses in a renal transplant patient: aggressive management improves outcome. Transplantation 1997; 63:160-2.
40. Salem FA, Kannangara DW, Nachum R. Cerebral chromomycosis. Arch Neurol 1983; 40:173-4.
41. Sandhyamani S, Bhatia R, Mohapatra LN, et al. Cerebral cladosporiosis. Surg Neurol 1981; 15:431-4.
42. Seaworth BJ, Kwon-Chung KJ, Hamilton JD, et al. Brain abscess caused by a variety of Cladosporium trichoides. Am J Clin Pathol 1983; 79:747-52.
43. Sekhon AS, Galbraith J, Mielke BW, et al. Cerebral phaeohyphomycosis caused by Xylohypha bantiana, with a review of the literature. Eur J Epidemiol 1992; 8:387-90.
44. Shields GS, Castillo M. Myelitis caused by Cladophialophora bantiana. AJR Am J Roentgenol 2002; 179:278-9.
45. Sood P, Dogra V, Thakur A, et al. Brain abscess due to Xylohypha bantiana. Scand J Infect Dis 2000; 32:708-9.
46. Symmers WS. A case of cerebral chromoblastomycosis (cladosporiosis) occurring in Britain as a complication of polyarteritis treated with cortisone. Brain 1960; 83:37-51.
47. Walz R, Bianchin M, Chaves ML, et al. Cerebral phaeohyphomycosis caused by Cladophialophora bantiana in a Brazilian drug abuser. J Med Vet Mycol 1997; 35:427-31.
48. Watson KC. Cerebral chromoblastomycosis. J Pathol Bacteriol 1962; 84:233-7.
49. Watson KC, Lines GM. Brain abscess due to the fungus Hormodendrum. S Afr Med J 1957; 31:1081-2.
50. Wilson E. Cerebral abscess caused by Cladosporium bantianum: case report. Pathology 1982; 14:91-6.
51. Campbell CK, Al-Hedaithy SSA. Phaeohyphomycosis of the brain caused by Ramichloridium mackenziei sp nov in Middle Eastern countries. J Med Vet Mycol 1993; 31:325-32.
52. Kanj SS, Amr SS, Roberts GD. Ramichloridium mackenziei brain abscess: report of two cases and review of the literature. Med Mycol 2001; 39:97-102.
53. Khan ZU, Lamdhade SJ, Johny M, et al. Additional case of Ramichloridium mackenziei cerebral phaeohyphomycosis from the Middle East. Med Mycol 2002; 40:429-33.
54. Podnos YD, Anastasio P, De La ML, et al. Cerebral phaeohyphomycosis caused by Ramichloridium obovoideum (Ramichloridium mackenziei): case report. Neurosurgery 1999; 45:372-5.
55. Naim UR, Mahgoub ES, Chagla AH. Fatal brain abscesses caused by Ramichloridium obovoideum: report of three cases. Acta Neurochir (Wien) 1988; 93:92-5.
56. Sutton DA, Slifkin M, Yakulis R, et al. US case report of cerebral phaeohyphomycosis caused by Ramichloridium obovoideum (R. mackenziei): criteria for identification, therapy, and review of other known dematiaceous neurotropic taxa. J Clin Microbiol 1998; 36:708-15.
57. Kralovic SM, Rhodes JC. Phaeohyphomycosis caused by Dactylaria (human dactylariosis): report of a case with review of the literature. J Infect 1995; 31:107-13.
58. Patel R, Gustaferro CA, Krom RA, et al. Phaeohyphomycosis due to Scopulariopsis brumptii in a liver transplant recipient. Clin Infect Dis 1994; 19:198-200.
59. Sides EH III, Benson JD, Padhye AA. Phaeohyphomycotic brain abscess due to Ochroconis gallopavum in a patient with malignant lymphoma of a large cell type. J Med Vet Mycol 1991; 29:317-22.
60. Singh N, Chang FY, Gayowski T, et al. Infections due to dematiaceous fungi in organ transplant recipients: case report and review. Clin Infect Dis 1997; 24:369-74.
61. Vukmir RB, Kusne S, Linden P, et al. Successful therapy for cerebral phaeohyphomycosis due to Dactylaria gallopava in a liver transplant recipient. Clin Infect Dis 1994; 19:714-9.
62. Adam RD, Paquin ML, Petersen EA, et al. Phaeohyphomycosis caused by the fungal genera Bipolaris and Exserohilum: a report of 9 cases and review of the literature. Medicine (Baltimore) 1986; 65:203-17.
63. Biggs PJ, Allen RL, Powers JM, et al. Phaeohyphomycosis complicating compound skull fracture. Surg Neurol 1986; 25:393-6.
64. Latham RH. Bipolaris spicifera meningitis complicating a neurosurgical procedure. Scand J Infect Dis 2000; 32:102-3.
65. Yoshimori RN, Moore RA, Itabashi HH, et al. Phaeohyphomycosis of brain: granulomatous encephalitis caused by Drechslera spicifera. Am J Clin Pathol 1982; 77:363-70.
66. Santosh V, Khanna N, Shankar SK, et al. Primary mycotic abscess of the brain caused by Fonsecaea pedrosoi: case report. J Neurosurg 1995; 82:128-30.
67. Takahashi H, Sasaki A, Arai T, et al. Chromoblastomycosis in the cisterna magna and the spinal subarachnoid space. J Neurosurg 1973; 38:506-9.
68. Zaharopoulos P, Schnadig VJ, Davie KD, et al. Multiseptate bodies in systemic phaeohyphomycosis diagnosed by fine needle aspiration cytology. Acta Cytol 1988; 32:885-91.
69. Abbott SP, Sigler L, McAleer R, et al. Fatal cerebral mycoses caused by the ascomycete Chaetomium strumarium. J Clin Microbiol 1995; 33:2692-8.
70. Fuste FJ, Ajello L, Threlkeld R, et al. Drechslera hawaiiensis: causative agent of a fatal fungal meningo-encephalitis. Sabouraudia 1973; 11:59-63.
71. Morton SJ, Midthun K, Merz WG. Granulomatous encephalitis caused by Bipolaris hawaiiensis. Arch Pathol Lab Med 1986; 110:1183-5.
72. Anandi V, John TJ, Walter A, et al. Cerebral phaeohyphomycosis caused by Chaetomium globosum in a renal transplant recipient. J Clin Microbiol 1989; 27:2226-9.
73. Guppy KH, Thomas C, Thomas K, et al. Cerebral fungal infections in the immunocompromised host: a literature review and a new pathogen - Chaetomium atrobrunneum: case report. Neurosurgery 1998; 43:1463-9.
74. Huttova M, Kralinsky K, Horn J, et al. Prospective study of nosocomial fungal meningitis in children - report of 10 cases. Scand J Infect Dis 1998; 30:485-7.
75. Krcmery V Jr, Spanik S, Danisovicova A, et al. Aureobasidium mansoni meningitis in a leukemia patient successfully treated with amphotericin B. Chemotherapy 1994; 40:70-1.
76. Ajanee N, Alam M, Holmberg K, et al. Brain abscess caused by Wangiella dermatitidis: case report. Clin Infect Dis 1996; 23:197-8.
77. Chang CL, Kim DS, Park DJ, et al. Acute cerebral phaeohyphomycosis due to Wangiella dermatitidis accompanied by cerebrospinal fluid eosinophilia. J Clin Microbiol 2000; 38:1965-6.
78. Al-Mohsen IZ, Sutton DA, Sigler L, et al. Acrophialophora fusispora brain abscess in a child with acute lymphoblastic leukemia: review of cases and taxonomy. J Clin Microbiol 2000; 38:4569-76.
79. Kantarcioglu AS, Yucel A, De Hoog GS. Case report: isolation of Cladosporium cladosporioides from cerebrospinal fluid. Mycoses 2002; 45:500-3.
80. McGinnis MR, Lemon SM, Walker DH, et al. Fatal cerebritis caused by a new species of Cladophialophora. Stud Mycol 1999; 43:166-71.
81. Friedman AD, Campos JM, Rorke LB, et al. Fatal recurrent Curvularia brain abscess. J Pediatr 1981; 99:413-5.
82. Baddley JW, Moser SA, Sutton DA, et al. Microascus cinereus (anamorph Scopulariopsis) brain abscess in a bone marrow transplant recipient. J Clin Microbiol 2000; 38:395-7.
83. Tekkok IH, Higgins MJ, Ventureyra EC. Posttraumatic gas-containing brain abscess caused by Clostridium perfringens with unique simultaneous fungal suppuration by Myceliophthora thermophila: case report. Neurosurgery 1996; 39:1247-51.
84. Palacio-Hernanz A, Moore MK, Campbell CK, et al. Infection of the central nervous system by Rhinocladiella atrovirens in a patient with acquired immunodeficiency syndrome. J Med Vet Mycol 1989; 27:127-30.
85. Madrigal V, Alonso J, Bureo E, et al. Fatal meningoencephalitis caused by Scedosporium inflatum (Scedosporium prolificans) in a child with lymphoblastic leukemia. Eur J Clin Microbiol Infect Dis 1995; 14:601-3.
86. Arunkumar MJ, Rajshekhar V, Chandy MJ, et al. Management and outcome of brain abscess in renal transplant recipients. Postgrad Med J 2000; 76:207-11.
87. Musella RA, Collins GH. Cerebral chromoblastomycosis: case report. J Neurosurg 1971; 35:219-22.
88. Osiyemi OO, Dowdy LM, Mallon SM, et al. Cerebral phaeohyphomycosis due to a novel species: report of a case and review of the literature. Transplantation 2001; 71:1343-6.
89. Tintelnot K, De Hoog GS, Thomas E, et al. Cerebral phaeohyphomycosis caused by an Exophiala species. Mycoses 1991; 34:239-44.
90. Umabala P, Lakshmi V, Murthy AR, et al. Isolation of a Nodulisporium species from a case of cerebral phaeohyphomycosis. J Clin Microbiol 2001; 39:4213-8.
91. Hart AP, Sutton DA, McFeeley PJ, et al. Cerebral phaeohyphomycosis caused by a dematiaceous Scopulariopsis species. Clin Neuropathol 2001; 20:224-8.
92. Casadevall A, Rosas AL, Nosanchuk JD. Melanin and virulence in Cryptococcus neoformans. Curr Opin Microbiol 2000; 3:354-8.
93. Dixon DM, Polak A, Szaniszlo PJ. Pathogenicity and virulence of wild-type and melanin-deficient Wangiella dermatitidis. J Med Vet Mycol 1987; 25:97-106.
94. Feng B, Wang X, Hauser M, et al. Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala) dermatitidis. Infect Immun 2001; 69:1781-94.
95. Schnitzler N, Peltroche-Llacsahuanga H, Bestier N, et al. Effect of melanin and carotenoids of Exophiala (Wangiella) dermatitidis on phagocytosis, oxidative burst, and killing by human neutrophils. Infect Immun 1999; 67:94-101.
96. Kwon-Chung KJ, Polacheck I, Popkin TJ. Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice. J Bacteriol 1982; 150:1414-21.
97. Jacobson ES. Pathogenic roles for fungal melanins. Clin Microbiol Rev 2000; 13:708-17.
98. Butler MJ, Day AW. Fungal melanins: a review. Can J Microbiol 1998; 44:1115-36.
99. Hamilton AJ, Gomez BL. Melanins in fungal pathogens. J Med Microbiol 2002; 51:189-91.
100. Fidler IJ, Schackert G, Zhang R, et al. The biology of melanoma brain metastasis. Cancer Metastasis Rev 1999; 18:387-400.
101. Padhye AA, Bennett JE, McGinnis MR, et al. Biosafety considerations in handling medically important fungi. Med Mycol 1998; 36(Suppl 1):258-65.
102. Kimura M, McGinnis MR. Fontana-Masson-stained tissue from culture-proven mycoses. Arch Pathol Lab Med 1998; 122:1107-11.
103. Evans RW. Complications of lumbar puncture. Neurol Clin 1998; 16:83-105.
104. Chun CH, Johnson JD, Hofstetter M, et al. Brain abscess: a study of 45 consecutive cases. Medicine (Baltimore) 1986; 65:415-31.
105. van Crevel H, Hijdra A, de Gans J. Lumbar puncture and the risk of herniation: when should we first perform CT? J Neurol 2002; 249:129-37.
106. De Hoog GS, Guarro J, Gene J, Figueras MJ. Atlas of clinical fungi. 2nd ed. Utrecht, The Netherlands: Centraalbureau voor Schimmelcultures, 2000.
107. Matsumoto T, Ajello L. Agents of phaeohyphomycosis. In: Ajello L, Hay RJ, eds. Medical mycology. 9th ed. London: Arnold, 1998:503-24.
108. McGinnis MR, Pasarell L. In vitro testing of susceptibilities of filamentous ascomycetes to voriconazole, itraconazole, and amphotericin B, with consideration of phylogenetic implications. J Clin Microbiol 1998; 36:2353-5.
109. Walsh TJ, Goodman JL, Pappas P, et al. Safety, tolerance, and pharmacokinetics of high-dose liposomal amphotericin B (AmBisome) in patients infected with Aspergillus species and other filamentous fungi: maximum tolerated dose study. Antimicrob Agents Chemother 2001; 45:3487-96.
110. Groll AH, Giri N, Petraitis V, et al. Comparative efficacy and distribution of lipid formulations of amphotericin B in experimental Candida albicans infections of the central nervous system. J Infect Dis 2000; 182:274-82.
111. Sharkey PK, Graybill JR, Rinaldi MG, et al. Itraconazole treatment of phaeohyphomycosis. J Am Acad Dermatol 1990; 23:577-86.
112. Groll AH, Piscitelli SC, Walsh TJ. Clinical pharmacology of systemic antifungal agents: a comprehensive review of agents in clinical use, current investigational compounds, and putative targets for antifungal drug development. Adv Pharmacol 1998; 44:343-499.
113. Johnson LB, Kauffman CA. Voriconazole: a new triazole antifungal agent. Clin Infect Dis 2003; 36:630-7.
114. de Lastours V, Lefort A, Zappa M, et al. Two cases of cerebral aspergillosis successfully treated with voriconazole. Eur J Clin Microbiol Infect Dis 2003; 22:297-9.
115. Perfect JR, Marr KA, Walsh TJ, et al. Voriconazole treatment for less-common, emerging, or refractory fungal infections. Clin Infect Dis 2003; 36:1122-31.
116. Francis P, Walsh TJ. Evolving role of flucytosine in immunocompromised patients: new insights into safety, pharmacokinetics, and antifungal therapy. Clin Infect Dis 1992; 15:1003-18.
117. Dixon DM, Polak A. In vitro and in vivo drug studies with three agents of central nervous system phaeohyphomycosis. Chemotherapy 1987; 33:129-40.
118. Polak A. Mode of action of 5-fluorocytosine and 5-fluorouracil in dematiaceous fungi. Sabouraudia 1983; 21:15-25.
119. Corrado ML, Kramer M, Cummings M, et al. Susceptibility of dematiaceous fungi to amphotericin B, miconazole, ketoconazole, flucytosine and rifampin alone and in combination. Sabouraudia 1982; 20:109-13.
120. Polak A. Antimycotic therapy of experimental infections caused by dematiaceous fungi. Sabouraudia 1984; 22:279-89.
121. McGinnis MR, Pasarell L. In vitro evaluation of terbinafine and itraconazole against dematiaceous fungi. Med Mycol 1998; 36:243-6.
122. Hay RJ. Therapeutic potential of terbinafine in subcutaneous and systemic mycoses. Br J Dermatol 1999; 141(Suppl 56):36-40.
123. McGinnis MR, Pasarell L, Sutton DA, et al. In vitro evaluation of voriconazole against some clinically important fungi. Antimicrob Agents Chemother 1997; 41:1832-4.
124. Espinel-Ingroff A. Comparison of in vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts. J Clin Microbiol 1998; 36:2950-6.
125. Espinel-lngroff A. In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens. J Clin Microbiol 1998; 36:198-202.
126. Cuenca-Estrella M, Ruiz-Diez B, Martinez-Suarez JV, et al. Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum. J Antimicrob Chemother 1999; 43:149-51.
127. Al Abdely HM, Najvar L, Bocanegra R, et al. SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ("Ramichloridium mackenziei"). Antimicrob Agents Chemother 2000; 44:1159-62.