The effect of six polymorphisms in the Apolipoprotein B gene on parameters of lipid metabolism in a Danish population

Clinical Genetics

Volumn 61, Issue 2, 2002, Pages 126-134

  Bentzen, Joan ^a   Jorgensen T ^b   Fenger, M ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

^b GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Apolipoprotein B; Arteriosclerosis; Hardy; Lipid metabolism; Polymorphism; Weinberg disequilibrium

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGE; AGED; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CODON; COHORT ANALYSIS; CONTROLLED STUDY; DENMARK; DIET RESTRICTION; DNA POLYMORPHISM; FEMALE; GENDER; GENE LINKAGE DISEQUILIBRIUM; HUMAN; LINEAR SYSTEM; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPID TRANSPORT; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL MODEL; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; STATISTICAL ANALYSIS;

ADULT; AGED; ALLELES; APOLIPOPROTEINS B; BODY MASS INDEX; CHOLESTEROL; CODON; COHORT STUDIES; DENMARK; FEMALE; GENOTYPE; HUMANS; LIPID METABOLISM; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 0036488089     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0004.2002.610207.x     Document Type: Article

References (41)

1. Lloyd-Jones DM, Larson MG, Beiser A, Levy D. Lifetime risk of developing coronary heart disease. Lancet, 1999: 353: 89-92.
2. Castelli WP, Doyle JT, Gordon T, Hames CG, Hjortland MC, Hulley SB et al. HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study. Circulation, 1977: 55: 767-772.
3. Patterson CC, McCrum E, McMaster D, Kerr M, Evans AE. Factors influencing total cholesterol and high-density lipoprotein cholesterol concentrations in a population at high coronary risk. Acta Med Scand (Suppl), 1988: 728: 150-158.
4. Hubert HB, Eaker ED, Castelli WP. Life-style correlates of risk factor change in young adults: an eight-year study of coronary heart disease risk factors in the Framingham offspring. Am J Epidemiol, 1987: 125: 812-831.
5. Hansen PS, Gerdes LU, Klausen IC, Gregersen N, Faergeman O. Polymorphisms in the Apolipoprotein B-100 Gene Contributes to Normal Variation in Plasma Lipids in 464 Danish Men Born in 1948. Hum. Genet, 1993: 91: 45-50.
6. Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP, Krauss RM, Vega GL et al. Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia. J Lipid Res 1990: 31: 1337-1349.
7. Ludwig EH, McCarthy BJ. Haplotype analysis of the human apolipoprotein B mutation associated with familial defective apolipoprotein B100. Am J Hum Genet, 1990: 47: 712-720.
8. Wu M-J, Bütler E, Bütler R, Schumaker VN. Identification of the base substitution responsible for the Ag (x/y) polymorphism of apolipoprotein B-100. Arterioscler Thromb, 1991: 11: 379-384.
9. Aalto-Setala K, Gylling H, Helve E, Kovanen PT, Miettinen TA, Turtola H et al. Genetic polymorphism of the apolipoprotein B gene locus influences serum LDL cholesterol level in familial hypercholesterolemia. Hum Genet, 1989: 82: 305-307.
10. Breguet G, Bütler R, Bütler-Brunner E, Sanchez-Mazas A. A worldwide population study of the Ag-system haplotypes, a genetic polymorphism of human low-density lipoprotein. Am J Hum Genet, 1990: 46: 502-517.
11. Leren TP, Bakken KS, Hoel V, Hjermann I, Berg K. Screening for mutations of the apolipoprotein B gene causing hypocholesterolemia. Hum Genet, 1998: 102: 44-49.
12. Delghandi M, Thangarajah R, Nilsen M, Grimsgaard S, Bonaa KH, Tonstad S et al. DNA polymorphisms of the apolipoprotein B gene (XbaI, EcoRI, and MspI RFLPs) in Norwegians at risk of atherosclerosis and healthy controls. Acta Cardiol, 1999: 54: 215-225.
13. De Benedictis G, Rose G, Mazzei R, Leone O, Crescibene L, Brancati C et al. EcoRI-RFLP of the Apo B gene: a study in a sample group from south Italy. Ann Hum Genet, 1991: 55 (2): 103-113.
14. Xu CF, Nanjee N, Tikkanen MJ, Huttunen JK, Pietinen P, Butler R et al. Apolipoprotein B amino acid 3611 substitution from arginine to glutamine creates the Ag (h/i) epitope: the polymorphism is not associated with differences in serum cholesterol and apolipoprotein B levels. Hum Genet, 1989: 82: 322-326.
15. Hosking JL, Bais R, Sobecki SK, Tallis GA, Bradley J, Thomas DW. Lipid parameters and apolipoprotein B RFLP studies: Comparison of normal and coronary heart disease groups as defined by angiography. Clin Biochem, 1992: 25: 303-308.
16. Robinson MT, Bütler R, Krauss RM. Association of a genetic polymorphism in humna apolipoprotein B-100 with intermediate density lipoprotein concentrations. Clin Genet, 1991: 40: 178-185.
17. Friedlander Y. Genetic contributions to LDL-C, Apo-B and LDL-C/Apo-B ratio in a sample of Israeli offspring with a parental history of myocardial infarction. Clin Genet, 1996: 50: 1-9.
18. Joergensen T. Prevalence of gallstones in a Danish population. Am J Epidemiol, 1987: 126: 912-921.
19. Rasmussen S, Torp-Pedersen C, Borch-Johnsen K, Ibsen H. Normal Values for ambulatory blood pressure and differences between casual blood pressure and ambulatory blood pressure: results from a Danish survey. J Hypertens, 1998: 16: 1415-1424.
20. Friedewald WT, Levy RI, Fredricson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem, 1972: 18: 459-502.
21. Weir BS. Disequilibrium. Genetic Data Analysis II. Sunderland, Massachusetts: Sinauer Associates Inc. Publishers 1996.
22. Lynch M, Walsh B. Resemblance between relatives. Genetics and Analysis of Quantitative Traits. Sunderland, Massachusetts: Sinauer Associates, Inc. 1998.
23. Schneider S, Roessli D, Excoffier L. Arlequin, Version 2.000: Software for Population Genetics Data Analysis. 2000.
24. Tybjaerg-Hansen A, Nordestgaard BG, Gerdes LU, Humphries S. Variation of apolipoprotein B gene is associated with myocardial infarction and lipoprotein levels in Danes. Atherosclerosis 1991: 89: 69-81.
25. Wu JH, Wen M-S, Lo S-K, Wu D. DNA polymorphisms of apolipoprotein B in the population of Taiwan. J Formos Med Assoc, 1993: 92: 330-335.
26. Misra A, Nishanth S, Pasha ST, Pandey RM, Sethi P, Raymond L. Relationship of XbaI and EcoRI polymorphisms of apolipoprotein-B gene to dyslipidemia and obesity in Asian Indians in North India. Indian Heart J, 2001: 53: 177-183.
27. Chauffert M, Larghero J, Ngohou-Botum K, Cisse A, Chevenne D, Trivin F. DNA polymorphisms of apolipoprotein B in the population of Senegal. Ann Hum Genet, 1997: 61: 525-529.
28. Bentzen J, Poulsen P, Vaag A, Beck-Nielsen H, Fenger M. The influence of the polymorphism in apolipoprotein B codon 2488 on insulin and lipid levels in a Danish twin population. Diabet Medicine 2002; in press
29. Tikkanen MJ. Immunogenetic polymorphism of apolipoprotein B in humans: Studies with a monoclonal anti-Ag (c) antibody. Am Heart J, 1987: 113: 428-432.
30. Mann CJ, Anderson TA, Read J, Chester SA, Harrison GB, Kochl S et al. The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins. J Mol Biol, 1999: 285: 391-408.
31. Bradbury P, Mann CJ, Köchl S, Anderson TA, Chester SA, Hancock JM et al. A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase. J Biol Chem, 1999: 274: 3159-3164.
32. Turner PR, Talmud PJ, Visvikis S, Ehnholm C, Tiret L. DNA polymorphisms of the apoprotein B gene are associated with altered plasma lipoprotein concentrations but not with perceived risk of cardiovascular disease. European Atherosclerosis Res Study. Atherosclerosis, 1995: 116: 221-234.
33. Friedlander Y, Berry EM, Eisenberg S, Stein Y, Leitersdorf E. Plasma lipids and lipoproteins response to a dietary challenge: analysis of four candidate genes. Clin Genet, 1995: 47: 1-12.
34. Saha N, Tay JS, Humphries SE. Apolipoprotein B-gene DNA polymorphisms (XbaI and EcoRI), serum lipids, and apolipoproteins in healthy Chinese. Genet Epidemiol, 1992: 9: 1-10.
35. Zaman MM, Ikemoto S, Yoshiike N, Date C, Yokoyama T, Tanaka H. Association fo apolipoprotein genetic polymorphisms with plasma cholesterol in a Japanese rural population: The Shibata study. Arterioscler Thromb Vasc Biol, 1997: 17: 3495-3504.
36. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature, 2001: 409: 860-921.
37. Berg K, Hames C, Dahlen G, Frick MH, Krishan I. Genetic variation in serum low density lipoproteins and lipid levels in man. Proc Natl Acad Sci USA, 1976: 73: 937-940.
38. Shelness GS, Sellers JA. Very-low-density lipoprotein as sembly and secretion. Curr Opin Lipidol, 2001: 12: 151-157.
39. Chan L. Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins. J Biol Chem, 1992: 267: 25621-25624.
40. Glisic S, Savic I, Alavantic D. Apolipoprotein B gene DNA polymorphisms (EcoRI and MspI) and serum lipid levels in the Serbian healthy population: interaction of rare alleles and smoking and cholesterol levels. Genet Epidemiol, 1995: 12: 499-508.
41. Lopez-Miranda J, Ordovas JM, Ostos MA, Marin C, Jansen S, Salas J et al. Dietary fat clearance in normal subjects is modulated by genetic variation at the apolipoprotein B gene locus. Arterioscler Thromb Vasc Biol, 1997: 17: 1765-1773.