An efficient synthesis of 3-substituted 3H-pyrimidin-4-ones

Organic Letters

Volumn 6, Issue 6, 2004, Pages 1013-1016

  Jeong, Jae Uk ^a   Chen, Xiaohong ^a   Rahman, Attiq ^a   Yamashita, Dennis S ^a   Luengo, Juan I ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM DERIVATIVE; AMIDE; AMINE; ESTER DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIMETHYLALUMINUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; SUBSTITUTION REACTION;

EID: 1642528055     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol049921v     Document Type: Article

References (23)

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16. Representative experimental procedure for 7a is described in Supporting Information.
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20. 13C NMR, IR, and LCMS.
21. (a) Representative experimental procedure for pyrimidinones 8a is described in Supporting Information. (b) Experimental procedure is described in Supporting Information.
22. Reactions were monitored and yields were reported by LCMS.
23. Trace amount (less than 5%) of 2-acetylamino-N-o-tolyl-benzamide (not shown) was also isolated.