Insulin-Like Growth Factor-I Blocks Dexamethasone-Induced Protein Degradation in Cultured Myotubes by Inhibiting Multiple Proteolytic Pathways: 2002 ABA Paper

Journal of Burn Care and Rehabilitation

Volumn 25, Issue 1, 2004, Pages 112-118

  Li, Bing Guo ^a   Hasselgren, Per Olof ^b   Fang, Cheng Hui ^a   Warden, Glenn D ^a  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAIN; CATHEPSIN B; DEXAMETHASONE; METHYLAMINE; MUSCLE PROTEIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTEASOME; SOMATOMEDIN C;

CONFERENCE PAPER; HORMONAL REGULATION; HUMAN; HUMAN CELL; MUSCLE ATROPHY; MUSCLE METABOLISM; MYOTUBE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; DEXAMETHASONE; INSULIN-LIKE GROWTH FACTOR I; MUSCLE FIBERS; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEASE INHIBITORS; RATS;

EID: 1642526416     PISSN: 02738481     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.BCR.0000105100.44745.36     Document Type: Conference Paper

References (34)

1. Roeder RA, Hossner KL, Sasser RG, Gunn JM. Regulation of protein turnover by recombinant human insulin-like growth factor-I in L6 myotube cultures. Horm Metab Res 1988;20:698-700.
2. Vary TC. Regulation of skeletal muscle protein turnover during sepsis. Curr Opin Clin Nutr Metab Care 1998;1:217-24.
3. Hobler SC, Williams A, Fischer JE, Hasselgren PO. Insulin like growth factor-I (IGF-I) stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats. Am J Physiol 1998;274:R571-6.
4. Fang CH, Li BG, Sun X, Hasselgren PO. Insulin-like growth factor-I reduces ubiquitin and ubiquitin-conjugating enzyme gene expression but does not inhibit muscle proteolysis in septic rats. Endocrinology 2000;141:2743-51.
5. Fang CH, Li BG, Wang JJ, Fischer JE, Hasselgren PO. Insulin-like growth factor-I (IGF-I) stimulates protein synthesis and inhibits protein breakdown in muscle from burned rats. JPEN J Parenter Enteral Nutr 1997;21:245-51.
6. Fang CH, Li BG, Wang JJ, Fischer JE, Hasselgren PO. Treatment of burned rats with insulin-like growth factor-I inhibits the catabolic response in skeletal muscle. Am J Physiol 1998; 275:R1091-8.
7. Cioffi WG, Gore DC, Rue LW, et al. Insulin-like growth factor-I lowers protein oxidation in patients with thermal injury. Ann Surg 1994;220:310-9.
8. Jacob R, Barrett E, Plewe G, Fagind KD, Sherwin RS. Acute effects of insulin-like growth factor-I on glucose and amino acid metabolism in the awake fasted rat. J Clin Invest 1989; 83:1717-23.
9. Kimura K, Kanda F, Okuda S, Chihara K. Insulin-like growth factor-I inhibits glucocorticord-induced glutamine synthetase activity, in cultured L6 rat skeletal muscle cells. Neurosci Lett 2001;302:154-6.
10. Berneis K, Ninnis R, Girard J, Frey BM, Keller U. Effects of insulin-like growth factor-I combined with growth hormone on glucocorticoid-induced whole-body protein catabolism in man. J Clin Endocrinol Metab 1997;82:2528-34.
11. Chrysis D, Underwood LE. Regulation of components of the ubiquitin system by insulin-like growth factor-I and growth hormone in skeletal muscle of rats made catabolic with dexamethasone. Endocrinology 1999;140:5635-41.
12. Fang CH, James JH, Ogle C, Fischer JE, Hasselgren PO. Influence of burn injury on protein metabolism in different types of skeletal muscle and the role of glucocorticoids. J Am Coll Surg 1995;180:33-42.
13. Tiao G, Fagan J, Roegner V, et al. Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids. J Clin Invest 1996;97:339-48.
14. Hasselgren PO. Glucocorticoids and muscle catabolism. Curr Opin Clin Nutr Metab Care 1999;2:201-5.
15. Hong DH, Forsberg NE. Effects of dexamethasone on protein degradation and protease gene expression in rat L8 myotube cultures. Mol Cell Endocrinol 1995;108:199-209.
16. Wang L, Luo GJ, Hasselgren PO. Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes. Shock 1998;10:298-306.
17. Solheim AE, Seglen PO. Cellular and lysosomal uptake of methylamine in isolated rat hepatocytes. Biochem J 1983; 210:929-36.
18. Dick LR, Cruikshank AA, Grenier L, Melandri FD, Nunes SL, Stein RL. Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clastolactacystin β-lactone. J Biol Chem 1996;271:7273-6.
19. Sorimachi H, Ishiura S, Suzaki K. Structure and physiological function of calpains. Biochem J 1997;328:721-32.
20. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantifies of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
21. Solomon V, Madihally S, Yarmush M, Toner M. Insulin suppresses the increased activities of lysosomal cathepsins and ubiquitin conjugation system in burn-injury rats. J Surg Res 2000;93:120-6.
22. Hobler SC, Williams A, Fischer D, Wang JJ, Sun X, Fischer JE, Monaco JJ, Hasselgren PO. Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis. Am J Physiol 1999;277:R434-40.
23. Edelstein CL, Wieder ED, Yaqoob MM, et al. The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury. Proc Natl Acad Sci USA 1995;92:7662-6.
24. Yao T, Cohen RE. Giant proteases: beyond the proteasome. Curr Biol 1999;9:R551-3.
25. Wray CJ, Tomkinson B, Robb BW, Hasselgren PO. Tripeptide-peptidase II expression and activity are increased in skeletal muscle during sepsis. Biochem Biophys Res Commun 2002;296:41-7.
26. Kanda R, Takatani K, Okuda S, Matsushita T, Chihara K. Preventive effects of insulin like growth factor-I on steroid-induced muscle atrophy. Muscle Nerve 1999;22:213-7.
27. Kaminiski HJ, Ruff RL. Endocrine myopathies (hyper- and hypo function of adrenal, thyroid, pituitary and parathyroid glands) and iatrogenic corticosteroid myopathy. In: Engel AG, Franzini-Armstrong C, editors. Myology. Vol 2. New York: McGraw-Hill; 1995. p. 1726-47.
28. Bowes SB, Benn JJ, Scobie IN, Umpleby AM, Lowy C, Sonksen PH. Leucine metabolism in patients with Cushing's syndrome before and after successful treatment. Clin Endocrinol 1993;39:591-8.
29. Fang CH, Li BG, Wray CJ, Hasselgren PO. Insulin-like growth factor-I inhibits lysosomal and proteasome-dependent proteolysis in skeletal muscle after burn injury. J Burn Care Rehabil 2002;23:318-25.
30. Fang CH, Tiao G, James JH, Ogle C, Fischer JE, Hasselgren PO. Burn injury stimulates multiple proteolytic pathways in skeletal muscle, including the ubiquitin-energy-dependent pathway. J Am Coll Surg 1995;180:161-70.
31. Tiao G, Fagan JM, Samuels N. Sepsis stimulates non-lysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle. J Clin Invest 1994; 94:2255-64.
32. Furuno K, Goodman MN, Goldberg AL. Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy. J Biol Chem 1990;265:8550-7.
33. Hong D, Forsberg NE. Effects of serum and insulin-like growth factor-I on protein degradation and protease gene expression in rat L8 myotubes. J Anim Sci 1994;72:2279-88.
34. Wing SS, Bedard N. Insulin-like growth factor-I stimulates degradation of an mRNA transcript encoding the 14 kDa ubiquitin-conjugating enzyme. Biochem J 1996;319:455-61.