Effect of Melatonin Treatment on Liver and Thymus Zinc Levels in Young and Middle-Aged Rats

Journal of Trace Elements in Experimental Medicine

Volumn 17, Issue 1, 2004, Pages 75-80

  Öztürk, Güler ^a   Akbulut, K Gonca ^b   Afrasyap, Lale ^c   Sevinç, Deniz ^a  

^a MALTEPE UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

^c MUGLA SITKI KOCMAN UNIVERSITY   (Turkey)

Author keywords

Liver; Melatonin; Thymus; Zinc

Indexed keywords

MELATONIN; NEUROHORMONE; TRACE ELEMENT; ZINC;

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IMMUNE SYSTEM; LIVER LEVEL; MALE; NONHUMAN; PINEAL BODY; PRIORITY JOURNAL; RAT; SPECTROPHOTOMETRY; THYMUS; TISSUE LEVEL;

RATTUS NORVEGICUS;

EID: 1642499568     PISSN: 0896548X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jtra.10055     Document Type: Article

References (18)

1. Rousseau A, Petren S, Plannthin J, Eklundh T, Nordin C. Serum and cerebrospinal fluid concentrations of melatonin: a pilot study in healthy male volunteers. J Neural Transm 1999;106:883-888.
2. Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Bielanski W, Brzozowska I, Stachura J, Hahn EG. The role of melatonin and L-tryptophanin prevention of acute gastric lesions induced by stress, ethanol, ischemia, and aspirin. J Pineal Res 1997;79-89.
3. Reiter RJ. Pharmalogical actions of melatonin in oxygen radical patophysiology. Life Sci 1997;60:2255-2271.
4. Mocchegiani E, Bulian D, Sabtarelli L, Tibaldi A, Muzzioli M, Lesnikov V, Pierpaoli W, Fabris N. The zinc pool is involved in the immune-reconstituting effect of melatonin in pinealectomized mice. J Pharmacol Exp Ther 1996;277:1200-1207.
5. Pierpaoli W, Regelsen W. The pineal control of aging. The effect of melatonin and pineal grafting on aging mice. Proc Natl Acad Sci USA 1194;91:787-791.
6. Mocchegiani E, Bulian D, Santarelli L, Tibaldi A, Pierpaoli W, Fabris N. The zinc-melatonin interrelationship a working hypothesis. Ann N Y Acad Sci 1994;719:298-307.
7. Fabris N, Mocchegiani E, Provinciali M. Plasticity of neuroendocrine-thymus interactions during aging. Exp Gerontol 1997;32:415-429.
8. Prasad AS. Clinical, biochemical and nutritional spectrum of zinc deficiency in human subjects: an update. Nutr Rev 1983;41:197-208.
9. Good RA, Lorenz E. Nutrition, immunity, aging and cancer. Nutr Rev 1998;46:62-67.
10. Good RA. Nutrition and immunity. J Clin Immunol 1981;1:3-11.
11. Muzzioli M, Mocchegiani E, Bressani N, Bevilacqua P, Fabris N. In vitro restoration by thymulin of natural killer activity of cells from old mice. Int J Immunopharmacol 1992;14:57-61.
12. Mocchegiani E, Bulian D, Santarelli L, Tibaldi A, Pierpaoli W, Fabris N. The immuno-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in aging mice. J Neuroimmunol 1994;53:189-201.
13. Maestroni GJM. The immunoneuroendocrine role of melatonin. J Pineal Res 1993;14:1-10.
14. Homsher R, Zak B. Spectrophotometric investigation of sensitive complexing agents for the determination of zinc in serum. Clin Chem 1985;31:1310-1313.
15. Delagrange P, Guardiola-Lemaitre B. Melatonin its receptor, and relationships with biological rhythm disorders. Clin Neuropharmacol 1997;20:482-510.
16. Cunnane SC, Horrobin DF, Manku MS, Oka M. Alteration of tissue zinc distribution and biochemical analysis of serum following pinealectomy in the rat. Endocr Rev 1979;6:311-319.
17. Öztürk G, Coşkun Ş, Erbaş D, Altunkaynak B. Effect of melatonin treatment on serum and tissue zinc levels in rats. J Trace Elem Exp Med 2002;15:1-8.
18. Pierpaoli W, Dall'ara A, Pedrinis E, Regelson W. The pineal control of aging. The effect of melatonin and pineal grafting on the survival of older mice. Ann NY Acad Sci 1991;621:291-313.